Serum lipids and brain-derived neurotrophic factor in a cross-section of male students with symptoms of depression at a university in Iran: an observational study

Abstract

Background Depression is a neuroprogressive disorder that is characterized by neurotransmitter derangement and decreased neurogenesis and neurotrophic factors including brain-derived neurotrophic factor (BDNF). Objectives To determine the lipid profiles and BDNF levels in university students at an institution in Iran and association of these factors with Beck Depression Inventory (BDI) scores. Methods We conducted an observational study of a cross-section of male students at the Ahvaz Jundishapur University of Medical Sciences in Iran. For each of the 100 participants, a BDI score was obtained and serum levels of BDNF were measured by enzyme-linked immunosorbent assay. Levels of serum lipids, including cholesterol, triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were measured using a biochemical analyzer. Castelli’s risk index type I (CRI-I), Castelli’s risk index type II (CRI-II), CRI-I = TG/HDL-C and CRI-II = LDL-cholesterol/ HDL-cholesterol, and atherogenic index of plasma (AIP), AIP = log (triglycerides/HDL-cholesterol), were calculated. Results Based on BDI scores, lower levels of BDNF, triglycerides, cholesterol, and HDL, but higher levels of LDL were found in participants with higher BDI scores. CRI-I was also increased in participants with depression. Conclusion The levels of BDNF and lipid factors are associated with the severity of depression in Iranian male university students. Deranged levels of BDNF and lipids may predispose depressed students to cardiovascular diseases.

Increased academic stress is associated with decreased plasma BDNF in Chilean college students

“…Male university students with the disorder showed reduced plasma BDNF levels. Their levels were measured using Beck-II, without linking to academic overload ( Tavakoli et al, 2017 ).…”

Short communication: Effects of Canarium indicum oil in enhancing brain-derived neurotrophic factor in rats

“…We also find that a high intake of cholesterol can lower BDNF serum level as seen in group 2 and significantly different compared to group 1 as shown in Table 1 (p=0.003). Some researchers have reported that high serum cholesterol can lower the level of BDNF (Tavakoli et al 2018;Sustar et al 2019), as well as may ruin plasticity neurons and the integrity of BBB (Freeman and Granholm 2012). BDNF lowest concentration as seen in group 2 may be due to the damage of BBB which involved as a transport pathway blood-brain BDNF (Klein et al 2011;Naegelin et al 2018;Gejl et al 2019).…”