A Crosstalk on Antimicrobial Peptides

Borah, Ankita; Deb, Bornali; Chakraborty, Supriyo

doi:10.1007/s10989-020-10075-x

Cited by 20 publications

(20 citation statements)

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“…Biofilm eradication agents (BEAs) are the target of many modern studies, and antimicrobial peptides (AMPs) are among the most likely BEAs [ 25 , 83 , 84 , 85 ]. AMPs are ubiquitous compounds produced by plants, invertebrates, and animals [ 86 ], and are relatively simple molecules (from 5 to 100 amino acids) with a molecular mass of 1–5 kDa [ 15 , 87 ]. They are predominantly cationic, so they are also called cationic antimicrobial peptides.…”

Section: Biofilm Treatment Strategiesmentioning

confidence: 99%

“…All plant AMPs are rich in cysteine and contain many disulfide bonds. In invertebrates, AMPs are found in hemolymph, hemocytes, phagocytes, and epithelial cells [ 86 , 87 ]. The vertebrate immune system consists of an innate and adaptive immune system.…”

Section: Biofilm Treatment Strategiesmentioning

confidence: 99%

“…The vertebrate immune system consists of an innate and adaptive immune system. AMPs can be isolated from leukocytes, phagocytes, epithelial macrophages, and body fluids [ 87 , 89 , 90 , 91 ]. The most prominent groups of mammalian AMPs are cathelicidins and defensins [ 57 , 92 ].…”

Section: Biofilm Treatment Strategiesmentioning

confidence: 99%

“…AMPs may have several activities: bactericidal, immune modulations, antiviral properties, anticarcinogenic properties, and they can prevent biofilm formation. Since AMP activity depends on their structure and sequence, it is crucial to consider both properties when categorizing them [ 86 , 87 ].…”

Section: Biofilm Treatment Strategiesmentioning

confidence: 99%

“…Antiviral AMPs defensins can bind to viral glycoprotein, after which viruses (such as herpes simplex virus) are unable to bind to the surface of the host cell [ 92 ]. Some AMPs (such as lactoferrin) can occupy specific mammalian cell receptors and prevent the virus from binding to its target receptor (such as heparan molecules for herpes simplex virus), and blocking viral interaction with the receptor [ 85 , 87 ]. Some antiviral AMPs can enter the host cell itself where they are located in the cytoplasm or the organelles and alter the host cell gene expression, thus helping the host defense mechanism [ 85 , 103 , 104 ].…”

Section: Biofilm Treatment Strategiesmentioning

confidence: 99%

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The Principles, Mechanisms, and Benefits of Unconventional Agents in the Treatment of Biofilm Infection

Talapko

Škrlec

2020

Pharmaceuticals

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Today, researchers are looking at new ways to treat severe infections caused by resistance to standard antibiotic therapy. This is quite challenging due to the complex and interdependent relationships involved: the cause of infection–the patient–antimicrobial agents. The sessile biofilm form is essential in research to reduce resistance to very severe infections (such as ESKAPE pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanni, Pseudomonas aeruginosa, and Enterobacter spp). The purpose of this study is to elucidate the mechanisms of the occurrence, maintenance, and suppression of biofilm infections. One form of biofilm suppression is the efficient action of natural antagonists of bacteria—bacteriophages. Bacteriophages effectively penetrate the biofilm’s causative cells. They infect those bacterial cells and either destroy them or prevent the infection spreading. In this process, bacteriophages are specific, relatively easy to apply, and harmless to the patient. Antimicrobial peptides (AMPs) support the mechanisms of bacteriophages’ action. AMPs could also attack and destroy infectious agents on their own (even on biofilm). AMPs are simple, universal peptide molecules, mainly cationic peptides. Additional AMP research could help develop even more effective treatments of biofilm (bacteriophages, antibiotics, AMPs, nanoparticles). Here, we review recent unconventional agents, such as bacteriophages and AMPs, used for eradication of biofilm, providing an overview of potentially new biofilm treatment strategies.

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Section: Biofilm Treatment Strategiesmentioning

confidence: 99%

Section: Biofilm Treatment Strategiesmentioning

confidence: 99%

Section: Biofilm Treatment Strategiesmentioning

confidence: 99%

Section: Biofilm Treatment Strategiesmentioning

confidence: 99%

Section: Biofilm Treatment Strategiesmentioning

confidence: 99%

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The Principles, Mechanisms, and Benefits of Unconventional Agents in the Treatment of Biofilm Infection

Talapko

Škrlec

2020

Pharmaceuticals

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Optimization of the Endotoxin Removal Performance of Solid-Phase Conjugated S3E3 Antimicrobial Peptide Using Response Surface Methodology

Sepahi

Norouzian

Cohan

et al. 2021

Int J Pept Res Ther

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Antimicrobial peptides: features, applications and the potential use against covid-19

Mabrouk

2022

Mol Biol Rep

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Background Antimicrobial peptides (AMPs) are a diverse class of molecules that represent a vital part of innate immunity. AMPs are evolutionarily conserved molecules that exhibit structural and functional diversity. They provide a possible solution to the antibiotic-resistance crisis. Main text These small cationic peptides can target bacteria, fungi, and viruses, as well as cancer cells. Their unique action mechanisms, rare antibiotic-resistant variants, broad-spectrum activity, low toxicity, and high specificity encourage pharmaceutical industries to conduct clinical trials to develop them as therapeutic drugs. The rapid development of computer-assisted strategies accelerated the identification of AMPs. The Antimicrobial Peptide Database (APD) so far contains 3324 AMPs from different sources. In addition to their applications in different fields, some AMPs demonstrated the potential to combat COVID-19, and hinder viral infectivity in diverse ways. Conclusions This review provides a brief history of AMPs and their features, including classification, evolution, sources and mechanisms of action, biosynthesis pathway, and identification techniques. Furthermore, their different applications, challenges to clinical applications, and their potential use against COVID-19 are presented.

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A Crosstalk on Antimicrobial Peptides

Cited by 20 publications

References 234 publications

The Principles, Mechanisms, and Benefits of Unconventional Agents in the Treatment of Biofilm Infection

The Principles, Mechanisms, and Benefits of Unconventional Agents in the Treatment of Biofilm Infection

Optimization of the Endotoxin Removal Performance of Solid-Phase Conjugated S3E3 Antimicrobial Peptide Using Response Surface Methodology

Antimicrobial peptides: features, applications and the potential use against covid-19

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