A CRP genetic polymorphism associated with the tumoral expression of CRP in esophageal cancer

Abstract

C-reactive protein (CRP) produced locally within esophageal cancer is associated with the prognosis and the rate of recurrence. CRP genetic polymorphisms reportedly affect serum CRP concentrations; however, there are no reports of an association between genetic polymorphisms and tumoral CRP expression. This study enrolled 73 Japanese patients classified with Stage IIA-IV thoracic esophageal squamous cell cancer, and also investigated their CRP genetic polymorphisms using DNA extracted from their peripheral blood. The study then assessed the association between CRP genetic polymorphisms and tumoral CRP expression. The results revealed a significant association between the CRP 1846C>T genetic polymorphism and tumoral CRP expression. This finding suggests that tumoral CRP production controlled by CRP genetics significantly influences tumor behavior.

Prognostic Impact of Intratumoral C-Reactive Protein Expression in Patients with Clear Cell Renal Cell Carcinoma

“…Jabs et al [20] demonstrated an autochthonous production of CRP by RCC cells in vitro and in vivo. Similarly, tumoral CRP production has been described in esophageal cancer [29]. On the other hand, Elsberger et al [23] performed RT-PCR for CRP in 10 clinical prostate specimens and found that mRNA CRP was undetectable in prostate tumor samples (unpublished results).…”

“…However, they found no significant association between elevated serum CRP and poor prognosis or cancer recurrence using several serum CRP cut-off values. Motoyama et al [29] emphasized that tumoral CRP synthesis is too low to influence serum CRP levels, but it is comparatively stable and may have a more important effect on the prognosis of esophageal cancer than serum CRP. These observations suggest that the prognostic utility of tumoral CRP expression might be superior to the assessment of its serum levels.…”

Clinical significance of preoperative C‐reactive protein and squamous cell carcinoma antigen levels in patients with penile squamous cell carcinoma

“…In the present study, we first show the relationship between preoperative serum CRP and SCC-Ag levels in penile SCC. C-reactive protein is an acute-phase reactant that responds to the tumour microenvironment, causing tumour cell death and local tissue damage [25], and high levels of this protein have been linked to cancer risk and/or progression in various malignancies [13][14][15]. In the present study, elevated CRP levels were associated with progressive tumour characteristics, including ENE (P < 0.001), pelvic LNM (P = 0.007), pathological tumour status (P = 0.002), and pathological nodal status (P < 0.001; Table 2), consistent with several previous studies [16,17].…”

“…An elevated CRP concentration is independently correlated with tumour load and disease progression, which is also correlated with survival in various cancers [14,15], and two recent studies have shown that CRP correlates with tumour burden in penile cancer [16,17]. Another potential prognostic marker in penile cancer is SCC antigen (SCC-Ag), a serum tumour marker used for various human SCCs [18,19], and an elevated level of SCC-Ag has been reported to be associated with clinical outcome in patients with penile cancer [19][20][21]; however, to the best of our knowledge, the relationship between CRP and SCC-Ag levels and their potential value in combination as a prognostic marker of survival in penile cancer have not been previously explored.…”

Genotype CC of rs1800947 in the C-Reactive Protein Gene May Increase Susceptibility to Colorectal Cancer: a Meta-Analysis

“…Functional genetic variation of this gene may influence the production or action of CRP, which subsequently modulate inflammatory response to influence cancer risk. Single nucleotide polymorphism (SNP) of this gene has been wildly investigated the association with serum CRP levels (Kong and Lee, 2012), tumoral expression of CRP (Motoyama et al, 2013) and risk of cancer (Yang et al, 2011;Huang et al, 2013;Xu et al, 2013). Several identified SNP of CRP gene were observed to be related to cancer risk and prognosis of patients with malignancy (Yang et al, 2011;Huang et al, 2013) meanwhile other findings supported the opposite results (Xu et al, 2013).…”