Genotype CC of rs1800947 in the C-Reactive Protein Gene May Increase Susceptibility to Colorectal Cancer: a Meta-Analysis

Chen, Xiaolin; Liao, Yongqiang; Liu, Jianrong

doi:10.7314/apjcp.2014.15.6.2663

Cited by 3 publications

(3 citation statements)

References 36 publications

(31 reference statements)

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“…The CRP 1846C>T polymorphism predicted lymph node metastasis more accurately than computed tomography (Motoyama et al, 2013). Single nucleotide polymorphisms of CRP are also related to risk and prognosis of cancer patients, and genotype CC of rs1800947 in CRP has been shown to be associated with increased cancer risk (Chen et al, 2014). These findings suggest that CRP not only exists as a marker of inflammation, but also has some unknown effects on the proliferation and metastasis of esophageal cancer.…”

Section: Discussionmentioning

confidence: 90%

Prognostic Value of C-Reactive Protein in Esophageal Cancer: a Meta-analysis

Zheng

Cao²,

Cui³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The classical inflammatory biomarker, C-reactive protein (CRP), has been identified to be related to progression of esophageal cancer. Some research showed that elevated pretreatment serum CRP indicated a poor prognosis, but results have been inconsistent. Materials and Methods: We searched the Medline, Embase and the Cochrane Central Search Library for suitable studies and a meta-analysis of eleven (1,886 patients) was conducted to examine the relationship between elevated serum CRP level and overall survival (OS) in esophageal cancer cases. Moreover, correlation analyses were conducted to assess links between pretreatment serum CRP level and tumor node metastasis (TNM) stage as well as T, N, M grade, respectively. Results: The pooled analysis showed that elevated pretreatment serum CRP level was significantly associated with poorer overall survival (HR 2.09, 95%CI 1.52-2.87, p<0.01). Subgroup analyses were conducted by "country", "cut-off value", "treatment" and "number of patients", and no single factor could alter the result. Elevated pretreatment serum CRP was significantly correlated with more advanced TNM stage and T, N, M grade respectively. Conclusions: Elevated pretreatment serum CRP levels are associated with poorer prognosis in esophageal cancer patients, and could serve as a useful biomarker for outcome prediction.

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Section: Discussionmentioning

confidence: 90%

Prognostic Value of C-Reactive Protein in Esophageal Cancer: a Meta-analysis

Zheng

Cao²,

Cui³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Rs1800947 is a synonymous coding polymorphism located on exon 2 of the CRP gene, which was reported for the first time by Cao et al [28]. Subsequently, various diseases have been associated with rs1800947, such as coronary artery disease [5,6], myocardial infarction [7][8][9][10], cerebrovascular ischemia-related disease [29][30][31], prostate cancer [12,13], colorectal cancer [14], diabetes [32], and depression [33]. The association of this SNP with low CRP levels was also described in myocardial infarction [7], coronary artery bypass surgery [6], coronary artery disease [5], cerebrovascular ischemia-related disease [31], diabetes [32], prostate cancer [12], and oesophageal cancer [34].…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, CRP polymorphisms have been associated with various kinds of inflammatory diseases, such as bacterial infections [3,4], heart disorders [5][6][7][8][9][10], and malignant tumours [11][12][13][14]. Specific SNPs have previously been linked to preterm birth and labour [15,16].…”

Section: Introductionmentioning

confidence: 99%

Association of C-reactive protein and Interleukin-6 single nucleotide polymorphisms with preterm labour: results of a pilot study

Sato

Miura

Onodera

et al. 2021

Preprint

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Preterm labour (PTL) can be described as an inflammatory event. C-reactive protein (CRP) and Interleukin-6 (IL-6) are key members of the innate immune response that play major roles in inflammation. The main objective of this case-control study was to determine the association of specific CRP and IL-6 polymorphisms with PTL. The study was carried out in a total of 31 Japanese women with PTL and 28 control women with normal pregnancy. Four SNPs in the CRP gene (rs1800947, rs3091244, rs2794521, and rs3093059) and two SNPs in the IL-6 gene (rs2097677 and rs1800795) were genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Biochemical parameters were assayed and cervical length measurements were performed with ultrasound sonography. There were no significant differences in inflammatory markers, including white blood cell count, CRP, neutrophil elastase in cervical mucous, and foetal fibronectin in vaginal discharge, between the PTL and control groups. The frequency of rs1800947 minor allele (C) was significantly higher in the PTL group than in the control group. This finding has not been previously reported. We suggest that mutations in rs1800947 may lead to PTL. Thus, the rs1800947 SNP may be useful as a genetic marker for PTL risk assessment in pregnant women.

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