It has been claimed that high-rise apartments, unlike perimeter block housing, cause social pathology; however, no studies have quantitatively proven this. Therefore, this study aimed to analyze the difference between space-use behavior and social interactions with a focus on high-rise apartments, the main residential mode in South Korea, and the newly created perimeter block housing. This was done by first comparing and analyzing the spatial configurations of high-rise apartments and perimeter block housing using the space syntax methodology. Second, the space-use behaviors that affect interaction were explained by regression analysis after analyzing correlations among the spatial configurations of individual residence locations, the frequency of use of community facilities, and interaction. Third, differences in interaction for people living in complexes with different spatial configurations were analyzed using t-tests. The main finding was that people whose living arrangements include a good spatial configuration or that often use children’s playgrounds interact more. Additionally, when the spatial configuration of a complex is systematic and the complex is closely connected to the city, the interaction between neighbors appears better. The results of this study demonstrate that block housing promotes interaction, which will be helpful for establishing new planning standards for sustainable apartments.