A cut‐off value of basal serum calcitonin for detecting macroscopic medullary thyroid carcinoma

Kwon, Hyemi; Kim, Won Gu; Choi, Yun Ju; Jang, Eun Kyung; Jeon, Min Ji; Song, Dong Eun; Baek, Jung Hwan; Ryu, Jin‐Sook; Hong, Suck Joon; Kim, Tae Yong; Kim, Won; Shong, Young Kee

doi:10.1111/cen.12562

Cited by 20 publications

(21 citation statements)

References 26 publications

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“…As we previously described, all US examinations were performed using one of two US systems; an iU22 unit or an HDI-5000 (Philips Healthcare, Bothell, WA, USA) equipped with a linear, high-frequency probe (4 to 15 MHz) [14]. The scanning protocol included both transverse and longitudinal real-time imaging of the thyroid.…”

Section: Methodsmentioning

confidence: 99%

Molecular Diagnosis Using Residual Liquid-Based Cytology Materials for Patients with Nondiagnostic or Indeterminate Thyroid Nodules

et al. 2016

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BackgroundMolecular analysis for common somatic mutations in thyroid cancer can improve diagnostic accuracy of fine-needle aspiration cytology (FNAC) in the nondiagnostic or indeterminate category of thyroid nodules. In this study, we evaluated the feasibility of molecular diagnosis from residual liquid-based cytology (LBC) material after cytological diagnosis.MethodsThis prospective study enrolled 53 patients with thyroid nodules diagnosed as nondiagnostic, atypia of undetermined significance (AUS), or follicular lesion of undetermined significance (FLUS) after FNAC. DNAs and RNAs were isolated from residual LBC materials. BRAFV600E and RAS point mutations, PAX8/peroxisome proliferator-activated receptor γ (PPARγ), RET/PTC1, and RET/PTC3 rearrangements were evaluated by real-time polymerase chain reaction and pyrosequencing.ResultsAll DNAs from 53 residual LBC samples could be analysed and point mutations were detected in 10 samples (19%). In 17 AUS nodules, seven samples (41%) had point mutations including BRAF (n=4), NRAS (n=2), and KRAS (n=1). In 20 FLUS nodules, three samples (15%) had NRAS point mutations. RNA from only one FLUS nodule could be analysed for rearrangements and there was no abnormality.ConclusionMolecular analysis for BRAF and RAS mutations was feasible in residual LBC materials and might be useful for diagnosis of indeterminate thyroid nodules.

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Section: Methodsmentioning

confidence: 99%

Molecular Diagnosis Using Residual Liquid-Based Cytology Materials for Patients with Nondiagnostic or Indeterminate Thyroid Nodules

et al. 2016

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“…In female patients with calcitonin levels ≥ 35 pg/ml and male patients with calcitonin levels ≥ 46 pg/ml, the risk for MTC is considered to be markedly elevated [20]. Other studies defined 60-65 pg/ml as cut-off values of calcitonin to detect MTC [21,22]. Earlier detection of MTC leads to better biochemical cure rates, as shown by Machens and Dralle in 2015 [17].…”

Section: Why Is Specialization Mandatory?mentioning

confidence: 99%

Medullary Thyroid Carcinoma: Why Is Specialization Mandatory?

Weber

2018

Visc Med

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Medullary thyroid carcinoma (MTC) represents a distinct form of thyroid cancer with a potentially aggressive behavior, early lymph node metastases, and sporadic as well as hereditary forms. Only surgery with total thyroidectomy and lymph node dissection is able to achieve biochemical cure. Due to the uncommon nature of MTC, a specialization in endocrine surgery for diagnosis as well as therapy of MTC seem to be mandatory for a successful treatment. Knowledge of genotype-phenotype correlations for hereditary forms or routine calcitonin screening for sporadic forms is important to analyze preoperative findings and plan surgical procedures. Postoperative follow-up depends on biochemical cure or monitoring for patients with elevated calcitonin levels.

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“…It accounts for about 3 -10 % of all thyroid cancer [1,2]. Although MTC is considered a well differentiated tumour, it is quite aggressive [3].…”

Section: Introductionmentioning

confidence: 99%

“…Although MTC is considered a well differentiated tumour, it is quite aggressive [3]. In fact it is the second most aggressive thyroid cancer after anaplastic carcinoma [4], with a mortality rate that ranges between 13, 4 -38% [2][3][4][5]. Its poor prognosis relies not only on its aggressive nature but also on its limited response to chemotherapy and radiation [6].…”

Section: Introductionmentioning

confidence: 99%

“…The routine measurement of serum calcitonin has been an area of great dispute, mostly when it comes to cost-effectiveness because of the low prevalence of MTC and the unnecessary thyroidectomies resulting from false positive results [2,4]. There are a number of other causes besides MTC for hypercalcitonemia [2,4], making the false positive results of serum calcitonin a true diagnostic challenge. However false negative results are very rare [4].…”

Section: Introductionmentioning

confidence: 99%

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“Atypical” Non-Secretory Medullary Thyroid Carcinoma: Case Report and Review of the Literature

Panagiotakou¹,

Ioannidis²,

Lilis³

et al. 2017

EMIJ

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A cut‐off value of basal serum calcitonin for detecting macroscopic medullary thyroid carcinoma

Abstract: Basal serum CT levels higher than 19·0 pmol/l can be a useful cut-off value for detecting macroscopic MTC, even though values below 19·0 pmol/l cannot exclude the presence of MTC like small volume MTC or premalignant C-cell hyperplasia.

Cited by 20 publications

References 26 publications

Molecular Diagnosis Using Residual Liquid-Based Cytology Materials for Patients with Nondiagnostic or Indeterminate Thyroid Nodules

Molecular Diagnosis Using Residual Liquid-Based Cytology Materials for Patients with Nondiagnostic or Indeterminate Thyroid Nodules

Medullary Thyroid Carcinoma: Why Is Specialization Mandatory?

“Atypical” Non-Secretory Medullary Thyroid Carcinoma: Case Report and Review of the Literature

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