Medullary Thyroid Carcinoma: Why Is Specialization Mandatory?

Weber, Theresia

doi:10.1159/000493809

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…Thyroid malignancies include differentiated thyroid cancer as papillary and follicular, poorly differentiated and anaplasic carcinoma (15)(16)(17). Also, medullar thyroid cancer is derived not from follicular cell, but from C-parafollicular cell with calcitonin secretion (18). Rarely thyroid metastasis is found in thyroid while primary thyroid lymphoma is frequently associated with an autoimmune chronic Hashimoto thyroiditis background (19).…”

Section: General Datamentioning

confidence: 99%

Post-thyroidectomy Hypocalcemia - Risk Factors and Management

Păduraru¹,

Ion²,

Cârșote³

et al. 2019

chr

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Section: General Datamentioning

confidence: 99%

Post-thyroidectomy Hypocalcemia - Risk Factors and Management

Păduraru¹,

Ion²,

Cârșote³

et al. 2019

chr

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“…Medullary thyroid carcinoma (MTC) is a rare type of thyroid cancer, repenting for 5–10% of all cases [6]. Unlike the 4 common types of thyroid cancer, MTC primarily originates from parafollicular cells and frequently exhibit intermediate malignant degree [7]. According to the pathogenesis, MTC can be further divided as hereditary form (accounts for 25% of MTC) and sporadic form (accounts for 75% of MTC) [8].…”

Section: Introductionmentioning

confidence: 99%

Two GEO MicroRNA Expression Profile Based High-Throughput Screen to Identify MicroRNA-31-3p Regulating Growth of Medullary Thyroid Carcinoma Cell by Targeting RASA2

Jiang

Shi

Zhu³

et al. 2019

Med Sci Monit

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Background Medullary thyroid carcinoma (MTC), a rare type of thyroid cancer, is a big challenge in clinical treatment. However, the pathogenesis of MTC remains poorly understand. MicroRNAs (miRNAs) were previously demonstrated to be involved in the pathogenesis of MTC, however, the roles of majority of miRNAs in MTC are still undetermined. Material/Methods Two GEO miRNA expression profiles (GSE40807, GSE97070) were downloaded, and the differentially expressed miRNAs (DEmiRNAs) of GSE40807 and GSE97070 were analyzed by bioinformatics methods. Expressions of miRNAs were detected by quantitative real-time polymerase chain reaction; cell proliferation was examined through Cell Counting Kit-8, colony formation and in vivo tumor growth assays; the interaction between miRNA and mRNA was verified by dual-luciferase reporter assay; functional analysis of target genes was performed using the Database for Annotation, Visualization and Integrated Discovery (DAVID, www.david.ncifcrf.gov ) software. Results Ten miRNAs were identified to be dysregulated in both GSE40807 and GSE97070 datasets, and miR-31-3p showed the highest change fold (Log fold change=−3.460625 in GSE40807 and Log fold change=−0.07084374 in GSE97070). MiR-31-3p expression was significantly downregulated in MTC, and low miR-31-3p expression showed a poor prognosis relative to high miR-31-3p expression ( P <0.05). Functionally, miR-31-3p inhibited MTC cell proliferation in vitro and in vivo . Functional analysis also showed that the target genes of miR-31-3p were involved in numerous of biochemical processes and pathways, of which Ras signaling pathway was selected for further study. RASA2, overexpressed in MTC, were negatively regulated by miR-31-3p. In addition, we found that knockdown of RASA2 inhibited MTC cell proliferation. Conclusions Reduced expression level of miR-31-3p might play a key role in the tumorigenesis of MTC by targeting critical pathways, especially Ras signaling pathway.

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“…For this reason, the only cytoreductive treatment in these patients with locoregional disease is surgery [ 8 ]. In MTC, lymph nodes metastasis occurs as soon as the tumor develops, behavior that not seen in other differentiated thyroid cancers [ 9 , 10 ]. Due to the effect of lymph node involvement, on the prognosis of patients, based on American Joint Committee on Cancer (AJCC) system, the presence or absence of lymph nodes metastasis is significant in staging [ 11 ].There is a lot of controversy about surgical approach to cervical lymph nodes in MTC [ [12] , [13] , [14] ].…”

Section: Introductionmentioning

confidence: 99%