A Cutaneous Fibropapilloma from a Red Deer (<i>Cervus elaphus</i>) Associated with a Papillomavirus

Abstract

A cutaneous fibropapilloma was found on a Scottish red deer (Cervus elaphus), and a papillomavirus was isolated from it. The virus appeared to be related to bovine papillomavirus type 1 (BPVl) or type 2 (BPV2) because: (i) it cross-reacted in peroxidase-antiperoxidase tests with antisera raised against these virions; (ii) BPVl and BPV2 DNAs cross-hybridized to the red deer papillomavirus in situ; and (iii) BPVl and/or BPV2 DNA cross-hybridized to the red deer papillomavirus DNA on Southern blots under conditions of high stringency. These tests also revealed a unique restriction enzyme cleavage pattern for the red deer papillomavirus DNA.

Papillomavirus-associated fibropapillomas of red deer ( Cervus elaphus )

“…Thus, our data support the findings of Moar and Jarrett (1985) regarding the close relatedness of BPV1/BPV2 and the Red deer PV established by Southern blot analysis. Although the analysed L2 sequence represents the second most variable ORF of Delta-papillomavirus genomes (García-Vallvé et al, 2005) it is nevertheless suitable for the reconstruction of the phylogenetic relationship between the members of this genus, primarily by distance matrix based methods like neighbour-joining.…”

“…Both our cases presented virtually identical pathological lesions and the localisation of PV antigen in the epithelial layer covering both fibropapillomas was similar to earlier descriptions (Moar and Jarrett, 1985). The cross-reaction of anti-BPV1 antibodies with the Red deer papillomavirus confirms the close antigenic relatedness of Delta-papillomaviruses.…”

“…Fibropapillomatosis is caused by papillomaviruses (PVs) which are non-enveloped, icosahedral viruses, 50-55 nm in diameter, with a circular, double-stranded DNA genome, ranging from 7.4 to 8.6 kb. Besides the number of PVs identified in domestic animals several PVs have been described from fibropapillomas of wild cervid species such as whitetailed deer (Shope et al, 1958;Lancaster and Sundberg, 1982), mule deer (Lancaster and Sundberg, 1982), European elk (Moreno-Lopez et al, 1981), reindeer (Moreno-Lopez et al, 1987), red deer (McDiarmid, 1975;Moar and Jarrett, 1985), and roe deer (Erdélyi et al, 2008). Fibromatosis has been seen in Hungarian populations of roe deer (Takács and Nagy-Bozsoky, 1998;Kocsner, 2001;Erdélyi et al, 2008) and red deer (Hőnich et al, 1978).…”

“…Fibromatosis has been seen in Hungarian populations of roe deer (Takács and Nagy-Bozsoky, 1998;Kocsner, 2001;Erdélyi et al, 2008) and red deer (Hőnich et al, 1978). Sporadic occurrence of fibropapillomas on the skin of red deer has been reported from a few European countries only (McDiarmid, 1975;Moar and Jarrett, 1985;Pérez et al, 2002).…”

Bilateral ovarian teratoma in a free-living Iberian red deer (Cervus elaphus hispanicus)

“…In domestic species, they have been reported mainly in horses, but also in pigs, cattle, dogs, cats, domestic fowl, woodchucks (Marmota monax), rodents, the European brown hare (Lepus europaeus) and humans (Dehner et al 1970;Cotchin and Marchant 1977;Anderson and Johnson 1988;Karpenko and Bukovjan 1996;Basaraba et al 1998). In deer, descriptions of tumours in general are rare and in red deer (Cervus elaphus) have been limited mostly to neoplasms of the skin (Mear and Jarret 1985;Boch and Schneidawind 1988;Ippen 1995;). Teratomas have been reported in roe deer (Capreolus capreolus) (Rang 1979) and a Père David's deer (Elaphurus davidianus) (Yoon et al 1999).…”