A cyclic feeding regime: A new model in experimental gerontology

Kurguzova, Natalia I.; Krivoruchko, T. V.; Lebed, E. N.; Mikhailets, A. O.; Danladi, S. D.; Божков, А. И.; Girich, M. S.

doi:10.1134/s2079057014040079

Cited by 7 publications

(14 citation statements)

References 9 publications

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“…Formed epigenetic and metabolic memory determines the further choice of adaptation strategies. The metabolic memory inevitably leads to narrowing of further opportunities of choice of strategies and this leads to the formation of chronic conditions and an increase of the probability of death [4,5].…”

Section: Introductionmentioning

confidence: 99%

Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan

Ai¹,

Yu²

2016

J Gerontol Geriatr Res

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We investigated the role of metabolic memory in a choice of strategies for adaptation to stress influences. We used a model of rat overeating in early ontogenesis from birth to 21 days of life and investigated the maintenance of formed metabolic pattern in later ontogenesis.The following characteristics were measured: somatometric indicators, resistance of animals to a temperature stress of 32ᵒC, thyroxin and triiodothyronine content in blood serum, NO-synthase activity, the content of lipid hydroperoxides and antioxidant enzymes in different organs in animals of 3, 20 and 31 months of age under standard conditions of maintenance in control animals and after overeating in the early ontogenesis.It is shown that the metabolic pattern formed on the background of overeating from birth to 21 days remains until the later stages of ontogeny. The forming metabolic pattern is characterized by elevated content of thyroxin, increase of NO-synthase activity in various tissues and particularly in the brain, a small increase of lipid hydroperoxides and reduced antioxidant activity of some enzymes. Animals that overeated in the early ontogenesis, are characterized by lower resistance to high temperatures and shorter life expectancy compared to the animals contained in the standard terms.

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Section: Introductionmentioning

confidence: 99%

Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan

Ai¹,

Yu²

2016

J Gerontol Geriatr Res

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“…Previously, it was shown, that after 3 consecutive CFR cycle in young animals body mass lagged as compared to control by 18%, and old animals even exceeded in body mass the control group by 10% [8].…”

Section: Age-related Changes In Body Mass On Two Consecutive Cycles Of Feedingmentioning

confidence: 88%

“…All these stages comprised one cycle of the feeding regime. The CFR scheme is described in detail [8]. Experimental animals were regularly weighed at the same time before feeding.…”

Section: Methodsmentioning

confidence: 99%

“…We have developed another version of the experimental model of lifespan increasethe cyclic feeding regime (CFR) [8]. This model is of interest in several aspects: 1) it can be applied not only for young, but also to adult animals; 2) it allows to explore the features and characteristics of metabolic-epigenetic memory, since it is easy to determine the reproducibility of the response after repeated cycles of loss-renovation of body mass; 3) in future it can be extended to man, in contrast to the CR.…”

Section: Introductionmentioning

confidence: 99%

“…This model is of interest in several aspects: 1) it can be applied not only for young, but also to adult animals; 2) it allows to explore the features and characteristics of metabolic-epigenetic memory, since it is easy to determine the reproducibility of the response after repeated cycles of loss-renovation of body mass; 3) in future it can be extended to man, in contrast to the CR. After 3 cycles of CFR the mean lifespan of rats is just the same as in animals received CR diet all their life [8] [9]. Since 30% of mass loss, which occurs at the CFR and induces stress reaction, it was of interest to investigate the response of organism after 2 cycles of consecutive body mass losses-renovation in young and old animals.…”

Section: Introductionmentioning

confidence: 99%

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The Cyclic Feeding Regime Induces Decaying Age-Dependent Oxidative Stress and Regulates the Cell Chain of the Immunity

Божков¹,

Nikitchenko²,

Lebed³

et al. 2016

AAR

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We developed an experimental model of a cyclic feeding regime (CFR) that increased a lifespan in rats. The manifestations of oxidative stress and their interrelation with parameters of cell immunity were assessed in rats at CFR. It is shown that changes of body mass, liver mass and indexes of pro/antioxidant system after periods of starving-ad libitum nutrition at CFR diet in old animals were less pronounced than in young animals. The body mass loss of 30% in 14 days was accompanied by oxidative stress. Indexes of phagocytosis did not change, but activity of oxidase system of neutrophil was increased in 2 times. The response of metabolic and physiological systems on repeat starving-ad libitum nutrition cycles differs from the response to the initial cycle of CFR. This is interpreted as a change of adaptation strategy and the effect of metabolic memory, which influences the choice of organism strategy of adaptation for subsequent starving. The dynamics of change of the studied indexes in response to CFR was age-dependent. It was supposed that different answer to CFR in young and old animals is determined by the different amount of carbon and fat depots in young and old animals.

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Young and old animals “use” different strategies for adapting to the chronic effects of ethanol

Bozhkov,

Dobrianska,

Akzhyhitov

et al. 2024

Translational Medicine of Aging

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A cyclic feeding regime: A new model in experimental gerontology

Cited by 7 publications

References 9 publications

Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan

Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan

The Cyclic Feeding Regime Induces Decaying Age-Dependent Oxidative Stress and Regulates the Cell Chain of the Immunity

Young and old animals “use” different strategies for adapting to the chronic effects of ethanol

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