A Cytogenetic Register of Down Syndrome in Lebanon

Zahed, Laïla; Mégarbané, André

doi:10.1159/000016142

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…The increased incidence of Down syndrome in Dubai is comparable to the reported incidences among Arab nationals from several other regions, namely Kuwait, Saudi Arabia, Qatar, Israel and Libya, which are in the range of 1.93-3.5/1,000 live births ( table 2 ) [9][10][11][12][13][14][15][16][17][18] . The incidence of 3.13/1,000 observed in the UAE population in Dubai is higher than most of the other Arab populations except for Kuwait, where it is reported to be between 2.9 and 3.50/1,000 [9,10] .…”

Section: Discussionsupporting

confidence: 66%

“…The incidence of 3.13/1,000 observed in the UAE population in Dubai is higher than most of the other Arab populations except for Kuwait, where it is reported to be between 2.9 and 3.50/1,000 [9,10] . The mean maternal age (33.48 8 8.08 years, range 17-54 years) in UAE nationals was lower compared to Egypt (38.2 years) and Qatar (35.4 8 6.5 years, range 21-51), but was slightly higher than that of Lebanon (32.19 years) [17][18][19] . The number of mothers in the advanced maternal age group ( 1 35 years) as seen in our study (41.66%) is similar to Lebanon (41.5%), but is less than that reported in Qatar (48.5%).…”

Section: Discussionmentioning

confidence: 99%

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Incidence of Down Syndrome in Dubai, UAE

et al. 2006

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Objective: To describe incidence of Down syndrome in Dubai, United Arab Emirates (UAE). Subjects and Methods: A total of 63,398 newborn babies in Dubai (24,250 UAE nationals and 39,148 non-UAE) during a 5-year period of 1999–2003 were routinely examined by experienced nurses, neonatologists, pediatricians and/or general practitioners for symptoms of Down syndrome. Those suspected with Down syndrome were referred to the cytogenetic laboratory for karyotyping. Results: A total of 141 cases were confirmed cytogenetically as Down syndrome. Of these, 139 were trisomy 21 and of the remaining 2, 1 was a translocation and the other a mosaic. Theoverall incidence of Down syndrome in Dubai was 1/449 live births (2.2 per 1,000); 1/319 live births (3.13 per 1,000) among UAE nationals and 1/602 live births (1.66 per 1,000) among non-UAE nationals. The mean maternal age of UAE national mothers was 33.48 ± 8.08, with 41.66% of the mothers being in the advanced maternal age group (>35 years). The higher incidence of Down syndrome among UAE nationals is comparable to incidences reported for other Arab populations in the Middle Eastern region. Advanced maternal age, with mothers bearing children until their 50s and higher parity, appear to be the major contributing factors for the increased incidence. Conclusion: The study indicates the need to provide efficient genetic counseling and to introduce an effective antenatal screening program and prenatal diagnostic services to reduce the psychological and genetic burden on the families and community.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Incidence of Down Syndrome in Dubai, UAE

et al. 2006

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“…The reason behind this apparent high incidence of DS in Qatar is mainly due to the tendency towards increased maternal age with 48.5% of mothers above the age of 36 years. The median maternal age of 36 years in this study is significantly higher than the 32 years recorded from Lebanon (p < 0.001) (15), and 31 years in United Arab Emirates (p < 0.001) (16), but lower than from Egypt (p < 0.001) (6). The elevated maternal age is a consequence of social organization in Qatar, with the tradition of more mothers continuing to bear children until their late forties and early fifties.…”

Section: Frequency Of Different Karyotypes Among the Studied Down Syncontrasting

confidence: 67%

The incidence patterns of Down syndrome in Qatar

2006

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“…Carothers et al 29 . found a markedly lower sex ratio (0.98:1) and Zahed and Megarbane 30 more elevated sex ratio (1.66:1) than has been reported in other DS registers. Kovaleva analysed 55 papers which presented the sex ratio of DS, and reported that the DS sex ratio was predominantly male 31 .…”

Section: Discussionmentioning

confidence: 83%

Descriptive epidemiology of Down’s syndrome in Estonia

Reimand

Õunap

Žordania

et al. 2006

Paediatric Perinatal Epid

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The aim of the study was to investigate the livebirth prevalence of Down's syndrome (DS) in Estonia during the past 14 years, create a DS database and observe the effectiveness of prenatal screening. This is a population-based descriptive study. The study subjects were children with DS diagnosis born between the years 1990 and 2003. We collected data from genetic centres in Estonia, from the databases of DS support groups, from institutions for disabled children and from the registers of family doctors/paediatricians. Prenatal screening for chromosomal anomalies for women aged >or=35 years was started in Estonia in 1995. Therefore, we divided the DS children into two groups: 112 born between 1990 and 1994 comprise group I, and 127 born between 1995 and 2003 comprise group II. Group II was further divided into two subgroups: IIa, from 1995 to 1998, when screening of advanced maternal age (>or=35 years) commenced, and IIb, from 1999 to 2003, when screening of second trimester maternal serum for younger women commenced. Prenatally, 68 cases of DS were diagnosed between 1995 and 2003 in the whole of Estonia, and all of these pregnancies were terminated. This represents 34.9% of all delivered and prenatally detected DS cases from this period. The overall livebirth prevalence was 1.17 per 1000 livebirths. The livebirth prevalence in group I was 1.25 and in group II was 1.09 per 1000 livebirths. The second trimester maternal serum screening with advanced maternal age screening was more effective than advanced maternal age screening alone. The livebirth prevalence in group IIa was 1.22 and in group IIb 0.99 per 1000 livebirths. Overall, regular trisomy was found in 90.4%, translocation in 6.3% and mosaicism in 2.9%. The overall male to female sex ratio of DS was 1.09.

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A Cytogenetic Register of Down Syndrome in Lebanon

Cited by 7 publications

References 25 publications

Incidence of Down Syndrome in Dubai, UAE

Incidence of Down Syndrome in Dubai, UAE

The incidence patterns of Down syndrome in Qatar

Descriptive epidemiology of Down’s syndrome in Estonia

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