2021
DOI: 10.3906/biy-2107-54
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A cytoplasmic escapee: desmin is going nuclear

Abstract: It has been a long time since researchers have focused on the cytoskeletal proteins’ unconventional functions in the nucleus. Subcellular localization of a protein not only affects its functions but also determines the accessibility for cellular processes. Desmin is a muscle-specific, cytoplasmic intermediate filament protein, the cytoplasmic roles of which are defined. Yet, there is some evidence pointing out nuclear functions for desmin. In silico and wet lab analysis shows that desmin can enter and function… Show more

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Cited by 6 publications
(3 citation statements)
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“…As this immunomarker is not yet available in regular antibody panels, the ancillary study of myxoid liposarcoma of any location is limited to the examination of S100 and p16 expression and of the status of the TP53 mutation [ 33 , 34 , 35 ]. S100 expression within neoplastic cells can be used to differentiate myxoid liposarcoma from a non-adipocytic neoplasm with myxoid stroma, while p16 has proved to be practical in distinguishing the tumour in question from its benign counterparts [ 34 , 36 ]. Although the expression of TP53 within lesions from the pathologic spectrum of liposarcoma has been widely examined, researches do not provide evidence of a major significance of this mutation for the overall prognosis of the neoplastic disease [ 37 , 38 ].…”
Section: Discussionmentioning
confidence: 99%
“…As this immunomarker is not yet available in regular antibody panels, the ancillary study of myxoid liposarcoma of any location is limited to the examination of S100 and p16 expression and of the status of the TP53 mutation [ 33 , 34 , 35 ]. S100 expression within neoplastic cells can be used to differentiate myxoid liposarcoma from a non-adipocytic neoplasm with myxoid stroma, while p16 has proved to be practical in distinguishing the tumour in question from its benign counterparts [ 34 , 36 ]. Although the expression of TP53 within lesions from the pathologic spectrum of liposarcoma has been widely examined, researches do not provide evidence of a major significance of this mutation for the overall prognosis of the neoplastic disease [ 37 , 38 ].…”
Section: Discussionmentioning
confidence: 99%
“…Alterations of one of these parameters-for instance, due to amino acid substitutions-may lead to malfunction, e.g., some proteins may not be properly folded, and others may be too strongly bonded or sequestered by the chaperonin. In addition, other proteins that are found to be altered in the affected skeletal muscle tissue, such as desmin and αB-crystallin, as discussed later, may contribute to apoptosis [16,17].…”
Section: Histomorphological Abnormalities Associated With Cct Chapero...mentioning
confidence: 99%
“…Most studies focus on the role of microfilament or microtubule networks in cell adhesion and migration. However, new insights indicate an important role of the IF family in various cell types such as myoblasts ( Etienne-Manneville, 2018 ; Agnetti et al, 2021 ; Kural Mangit et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%