A daily intake of approximately 6 μg vitamin B-12 appears to saturate all the vitamin B-12–related variables in Danish postmenopausal women%

Bor, Mustafa Vakur; Lydeking-Olsen, Eva; Møller, Jan; Nexø, Ebba

doi:10.1093/ajcn/83.1.52

Cited by 91 publications

(76 citation statements)

References 37 publications

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“…The lower one was established by Valente et al [22] by using FPIA measurement and the higher one was set by Hvas and Nexo [23], Bor et al [24] and Llody-Wright et al [25] using CPB and ELISA analytical methods, respectively. The principal methodology run was RIA assay (65%) and the corresponding cut-off range was between 35 and 40 pmol/L.…”

Section: Holotranscobalaminmentioning

confidence: 99%

A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population

Aparicio‐Ugarriza¹,

Palacios²,

Alder

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

106

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Vitamin B 12 deficit is one of the most common vitamin deficiencies. However, there is no consensus on the cut-off points for vitamin B 12 and its co-markers, such as folate, holotranscobalamin, methylmalonic acid and homocysteine. In order to establish the state of the art about cut-off points used to determine vitamin B 12 deficiency in the last decades, the database MEDLINE was used for searching studies published in adults between December 1992 and May 2014 (69 articles), using search terms like 'vitamin B 12 ', 'cobalamin', 'cut-off', 'deficiency' alone or in combinations. Broad ranges of cut-off points for vitamin B 12 and its biomarkers were identified: vitamin B 12 ranged between 100 pmol/L and 350 pmol/L, holotranscobalamin 20-50 pmol/L, methylmalonic acid 0.210-0.470 μmol/L, homocysteine 10-21.6 μmol/L, serum folate 3.7-15.9 nmol/L and red blood cell 124-397 nmol/L. For the majority of studies, the potential influence of age, analytical methods, gender and fortified food consumption was not taken in account when choosing cut-off values. This could explain the discrepancies between studies on vitamin B 12 and folate deficiency prevalences. We conclude that there is inconsistency in the literature regarding vitamin B 12 cut-offs. It would be necessary to establish different reference cut-offs according to age, considering the analytical methods used.

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Section: Holotranscobalaminmentioning

confidence: 99%

A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population

Aparicio‐Ugarriza¹,

Palacios²,

Alder

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

106

View full text Add to dashboard Cite

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“…The directly linked macromolecular drugs to vitamin B 12 are susceptible to the degradation within the gastrointestinal tract. In addition, according to the limited uptake capacity of vitamin B 12 (2.4 µg/day for adult) (6), the amount of the therapeutic molecule that can be delivered as conjugate is limited. An attractive solution to overcome theses problems would be the incorporation of drug in nanoparticles coated with vitamin B 12 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Bioadhesive Capacity and Immunoadjuvant Properties of Vitamin B12-Gantrez Nanoparticles

et al. 2008

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“…These high doses, which ensure passive absorption (in humans), might be required for elderly with (mild) vitamin B12 deficiency or with absorption problems and are attainable with supplements rather than with food (such as meat and dairy products). It is less certain whether such high doses are also required for a general adult population, as Bor et al (2006) showed that a daily intake of 6 mg was sufficient to normalize all vitamin B12-related variables in 98 Danish postmenopausal women.…”

mentioning

confidence: 99%

Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations

et al. 2007

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Background/Objectives: Folate and vitamin B12 have been suggested to play a role in chronic diseases like cardiovascular diseases. The objectives are to give an overview of the actual intake and status of folate and vitamin B12 in general populations in Europe, and to evaluate these in view of the current vitamin recommendations and the homocysteine concentration. Methods: Searches in Medline with 'folic acid', 'folate' and 'vitamin B12', 'B12' or 'cobalamin' as key words were combined with the names of the European countries. Populations between 18 and 65 years were included. Results: Sixty-three articles reporting on studies from 15 European countries were selected. Low folate intakes were observed in Norway, Sweden, Denmark and the Netherlands. Low intakes of vitamin B12 were not common and only seen in one small Greek study. In the countries with a low intake of folate, the recommended levels were generally not achieved, which was also reflected in the folate status. Vitamin B12 intake was not strongly associated with the vitamin B12 status, which can explain why in the Netherlands and Germany the vitamin B12 status was inadequate, despite sufficient intake levels. In countries with a low folate intake in particular, the Hcy concentration was higher than ideal. Conclusions: Populations from the Nordic countries, the Netherlands, Germany and Greece may need to improve their intakes of folic acid, B12 or both to either meet the recommendations or to optimize their statuses. This could be achieved via a foodbased approach, food fortification or supplements.

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A daily intake of approximately 6 μg vitamin B-12 appears to saturate all the vitamin B-12–related variables in Danish postmenopausal women%

Abstract: A daily vitamin B-12 intake of 6 microg appeared to be sufficient to correct all the vitamin B-12-related variables measured in the postmenopausal Danish women in this study.

Cited by 91 publications

References 37 publications

A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population

A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population

Evaluation of Bioadhesive Capacity and Immunoadjuvant Properties of Vitamin B12-Gantrez Nanoparticles

Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations

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