A Dangerous Postwar Development in Science Teaching

Sampey, John R.

doi:10.1126/science.103.2686.734-a

Cited by 13 publications

(5 citation statements)

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“…Metabolic measurements are essentially zero when 95 per cent of the cells in a suspension are inhibited, but subculture will still detect viable cells after more than 99.99 per cent of the cells are dead. The unusually large amount of detergent required to kill the last few cells, which may be protected by clumping (DuBois and Dibblee, 1946), heightens the discrepancy between these two methods. From these considerations, and the results reported here, a parallelism between the inhibition of glycolysis and certain sensitive oxidations and the bactericidal activity of the cationic detergents may be accepted.…”

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confidence: 99%

The Action of Cationic Detergents on Bacteria and Bacterial Enzymes

et al. 1949

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The bactericidal action of the quaternary ammonium detergents has not yet been satisfactorily explained. Recent reviewers (Putnam, 1948; Rahn and Van Eseltine, 1947; cf. Glassman, 1948) have not agreed that the amounts of these detergents lethal to bacteria are insufficient to cause any general denaturation of the bacterial proteins (Valko, 1946). Action by enzyme inactivation, either primary or secondary to some other injury, has been repeatedly suggested. Respiratory and glycolytic activity is depressed by detergents, and the inhibiting amounts were later shown to parallel roughly the lethal amounts (Baker et al., 1941a,b). However, the frequent survival of cells at concentrations of detergent which produced marked respiratory inhibition has cast doubt on an action by direct inhibition of enzymes. Hotchkiss (1946) demonstrated that nitrogen and phosphate compounds diffuse out of the cells with bactericidal amounts of 1 This investigation was conducted under a contract of Dr. D. E. Green and Columbia University with the Committee on Medical Research of the Office of Scientific Research and Development and at the request of the Office of the Quartermaster General.

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Section: ]mentioning

confidence: 99%

The Action of Cationic Detergents on Bacteria and Bacterial Enzymes

et al. 1949

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“…Quaternary ammonium compounds, however, are not very effective in killing spores(41) 20. This synergistic effect was not demonstrable when pH changes were not carefully controlled(62).on September 8, 2020 by guest http://mmbr.asm.org/ Downloaded from…”

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confidence: 99%

Surface Active Agents and Their Application in Bacteriology

Glassman¹

1948

Bacteriological Reviews

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“…Quaternary ammonium compounds, however, are not very effective in killing spores(41) 20. This synergistic effect was not demonstrable when pH changes were not carefully controlled(62).on December 13, 2020 by guest http://mmbr.asm.org/ Downloaded from…”

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confidence: 99%