A database of 389 medicinal plants for diabetes

Babu, P G; Suneetha, G.; Boddepalli, Radha; Lakshmi, Vedurupaka Vasantha; Rani, T. S.; RamBabu, Yellapu; Kolli, Srinivas

doi:10.6026/97320630001130

Cited by 41 publications

(17 citation statements)

References 9 publications

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“…In India, indigenous herbal remedies such as Ayurveda and other Indian traditional medicine have since ancient times used plants in treatment of diabetes[10]. Ethnobotanical studies of traditional herbal remedies used for diabetes have identified more than 1,200 species of plants with hypoglycemic activity [3,11].…”

Section: Introductionmentioning

confidence: 99%

Potent α-amylase inhibitory activity of Indian Ayurvedic medicinal plants

Sudha

Zinjarde

Bhargava

et al. 2011

BMC Complement Altern Med

211

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BackgroundIndian medicinal plants used in the Ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. Pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via control of starch breakdown. In this study, seventeen Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory potential on PPA (porcine pancreatic α-amylase). Preliminary phytochemical analysis of the lead extracts was performed in order to determine the probable constituents.MethodsAnalysis of the 126 extracts, obtained from 17 plants (Aloe vera (L.) Burm.f., Adansonia digitata L., Allium sativum L., Casia fistula L., Catharanthus roseus (L.) G. Don., Cinnamomum verum Persl., Coccinia grandis (L.) Voigt., Linum usitatisumum L., Mangifera indica L., Morus alba L., Nerium oleander L., Ocimum tenuiflorum L., Piper nigrum L., Terminalia chebula Retz., Tinospora cordifolia (Willd.) Miers., Trigonella foenum-graceum L., Zingiber officinale Rosc.) for PPA inhibition was initially performed qualitatively by starch-iodine colour assay. The lead extracts were further quantified with respect to PPA inhibition using the chromogenic DNSA (3, 5-dinitrosalicylic acid) method. Phytochemical constituents of the extracts exhibiting≥ 50% inhibition were analysed qualitatively as well as by GC-MS (Gas chromatography-Mass spectrometry).ResultsOf the 126 extracts obtained from 17 plants, 17 extracts exhibited PPA inhibitory potential to varying degrees (10%-60.5%) while 4 extracts showed low inhibition (< 10%). However, strong porcine pancreatic amylase inhibitory activity (> 50%) was obtained with 3 isopropanol extracts. All these 3 extracts exhibited concentration dependent inhibition with IC50 values, viz., seeds of Linum usitatisumum (540 μgml-1), leaves of Morus alba (1440 μgml-1) and Ocimum tenuiflorum (8.9 μgml-1). Acarbose as the standard inhibitor exhibited an IC50 (half maximal inhibitory concentration)value of 10.2 μgml-1. Phytochemical analysis revealed the presence of alkaloids, tannins, cardiac glycosides, flavonoids, saponins and steroids with the major phytoconstituents being identified by GC-MS.ConclusionsThis study endorses the use of these plants for further studies to determine their potential for type 2 diabetes management. Results suggests that extracts of Linum usitatisumum, Morus alba and Ocimum tenuiflorum act effectively as PPA inhibitors leading to a reduction in starch hydrolysis and hence eventually to lowered glucose levels.

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Section: Introductionmentioning

confidence: 99%

Potent α-amylase inhibitory activity of Indian Ayurvedic medicinal plants

Sudha

Zinjarde

Bhargava

et al. 2011

BMC Complement Altern Med

211

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“…In this review, many disease-specific databases are observed. Databases for storing medicinal plant information used in asthma (Kasirajan et al, 2007), in diabetes (Arulrayan et al, 2007;Babu et al, 2006;Middha et al, 2009;Singh et al, 2009), in cancer (AAMD, 2011;Fang et al, 2005;Vetrivel et al, 2009), in anti-arthritic plants (Siddiqui et al, 2011) are some of the examples.…”

Section: Disease-specific Databasesmentioning

confidence: 99%

Challenges in developing medicinal plant databases for sharing ethnopharmacological knowledge

Ningthoujam¹,

Talukdar

Potsangbam

et al. 2012

Journal of Ethnopharmacology

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“…In India, a number of plants are mentioned in the ancient literature of Ayurveda and Siddha for the treatment of diabetic conditions. Indigenous remedies have been used in India for the treatment of diabetes mellitus since the time of Charaka and Sushruta [6] . Many Indian plants have been investigated for their beneficial use in different types of diabetes [7] .…”

Section: Introductionmentioning

confidence: 99%

Finding Needles in a Haystack: Application of Network Analysis and Target Enrichment Studies for the Identification of Potential Anti-Diabetic Phytochemicals

2014

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Diabetes mellitus is a debilitating metabolic disorder and remains a significant threat to public health. Herbal medicines have been proven to be effective anti-diabetic agents compared to synthetic drugs in terms of side effects. However, the complexity in their chemical constituents and mechanism of action, hinder the effort to discover novel anti-diabetic drugs. Hence, understanding the biological and chemical basis of pharmacological action of phytochemicals is essential for the discovery of potential anti-diabetic drugs. Identifying important active compounds, their protein targets and the pathways involved in diabetes would serve this purpose. In this context, the present study was aimed at exploring the mechanism of action of anti-diabetic plants phytochemicals through network and chemical-based approaches. This study also involves a focused and constructive strategy for preparing new effective anti-diabetic formulations. Further, a protocol for target enrichment was proposed, to identify novel protein targets for important active compounds. Therefore, the successive use of network analysis combined with target enrichment studies would accelerate the discovery of potential anti-diabetic phytochemicals.

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A database of 389 medicinal plants for diabetes

Cited by 41 publications

References 9 publications

Potent α-amylase inhibitory activity of Indian Ayurvedic medicinal plants

Potent α-amylase inhibitory activity of Indian Ayurvedic medicinal plants

Challenges in developing medicinal plant databases for sharing ethnopharmacological knowledge

Finding Needles in a Haystack: Application of Network Analysis and Target Enrichment Studies for the Identification of Potential Anti-Diabetic Phytochemicals

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