A database on endemic plants at Tirumala hills in India

Latheef, S.A.A.; Prasad, B. Krishna; Bavaji, Middi; Subramanyam, Guru

doi:10.6026/97320630002260

Cited by 22 publications

(15 citation statements)

References 4 publications

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“…They include B. sacra, B. frereana, B. neglecta, B. microphylla, B. papyrifera, B. ogadensis, B. pirottae, B. rivae, B. madagascariensis, B. socotrana, B. popoviana, B. nana, B. ameero, B. bullata, B. dioscoridis, B. elongata, B. serrata and B. ovalifoliolata. Only the last two species have been reported to be distributed in India (Arabia 2005;Latheef et al 2008). Sunnichan et al (2005) mentioned that B. serrata is the only species found in India.…”

Section: Introductionmentioning

confidence: 99%

“…Our field surveys in the areas of Tirumala Hills have shown that the local tribes and others make deep incisions on the main trunk to extract the gum and resin, causing damage to trees which leads to population depletion. The gum is used to treat a number of conditions including ulcers, fever, stomach pain, scorpion sting, amoebic dysentery and hydrocele, while bark decoction is used for joint and rheumatic pains (Henry 2006;Latheef et al 2008). We have investigated the floral biology, breeding behaviour, pollination and foraging behavior of pollinators of B. ovalifoliolata in its natural area, and the observations and results obtained are discussed in the light of the existing relevant information.…”

Section: Introductionmentioning

confidence: 99%

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Entomophily, ornithophily and anemochory in the self-incompatible Boswellia ovalifoliolata Bal. & Henry (Burseraceae), an endemic and endangered medicinally important tree species

Raju¹,

Lakshmi²,

Ramana³

et al. 2012

J. Threat. Taxa

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Boswellia ovalifoliolata (Burseraceae) is a narrow endemic and endangered deciduous tree species. Its flowering, fruiting and seed dispersal events occur in a leafless state during the dry season. The flowers are small, bisexual, mildly odoriferous and actinomorphic; weakly protandrous but strictly self-incompatible. While insects and sunbirds pollinate the flowers, floral characteristics suggest that entomophily is the principal mode. Both bud and flower feeding by a weevil and flower and fruit feeding by the Palm Squirrel have been found to affect the success of sexual reproduction. The Garden Lizard serves as a predator of pollinating insects, especially bees and wasps, thus influencing pollination of this tree species. Fruit set in open pollination is below 10%, rising to 34% in manual cross-pollination. Limitation of cross-pollination, space constraints for seed production from all flower ovules and availability of limited resources in rocky, dry litter of the forest floor appear to constrain higher fruit set. Mature fruits dehisce and disseminate their lightweight, papery winged seeds with the aid of wind. The study site being windy provides the necessary driving force for effective dispersal of seeds away from parent trees. Seed germination occurs following rainfall but further growth depends on soil water and nutritional status. The success rate of seedling recruitment is highly limited, and it could be due to nutrient-poor soil and water stress resulting from dry spells during the rainy season.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Entomophily, ornithophily and anemochory in the self-incompatible Boswellia ovalifoliolata Bal. & Henry (Burseraceae), an endemic and endangered medicinally important tree species

Raju¹,

Lakshmi²,

Ramana³

et al. 2012

J. Threat. Taxa

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“…belongs to the family papilionaceae/ fabaceae and popularly known as 'Red sander's (Naidu et al 2001). It was traditionally used in treatment for headache, skin diseases, fever, boils, scorpion-sting and to improve sight (Chopra et al 1956;Latheef et al, 2008). Previous chemical constituents revealed the presence of triterpenes, isoflavone, glucosids, savinin and calocedrin (Krishnaveni et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Genomic DNA Isolation and Purification of Two Endemic Medicinal Plants (Pterocarpus Santalinus Linn.F & Pimpinella Tirupatiensis Bal&Subr) of Seshachalam Hills, Tirumala.

Vipranarayana¹,

Prasad

Rajinikanth³

et al. 2012

JBLS

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Ptercarpus santalinus is an important endemic medicinal plant with high medicinal values that interfere with DNA extraction procedures and qualitative, quantitative agaros gel electrophoresis. An effective and low-cost protocol for isolating genomic DNA from the roots of Pterocarpus santilinus and Pimpinella tirupatiensis was described in this paper. It involved a modified CTAB method with distilled water pretreating samples. The A 260 /A 280 absorbance ratio of extracted DNA was found to be free from polysaccharide, poly-phenols and tannins contaminants ranged from 2.2 to 2.8 within the high level of purity.

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“…It mainly contains isoflavone glucosides and antitumor lignans like savinin and calocedrin 1 . Drinking of water twice a day in the cup of PS wood is in practice for treating diabetes 4,8,9 . Ethanol extract of stem-bark has been reported to have anti-hyperglycaemic activity 10 .…”

mentioning

confidence: 99%

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2019

IJPSR

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Background: Diabetic nephropathy (DN) is a primary cause of end-stage renal disease globally. Activation of mTOR and reduced autophagy has been identified as one of the pathogenic pathways. The presently available drugs have been successful in inhibiting the mTOR signaling, but show low oral bioavailability and suboptimal solubility. Rapamycin is a selective inhibitor of mTOR, shown significant protection against DN. However, its continuous use is associated with side effects. Thus, the search for novel drugs is on great demand. In the present study, in-silico approaches have been adopted to identify potential compounds with optimal oral bioavailability and better solubility properties, with no toxic effect. Materials and Method: The receptor protein mTOR with PDB ID: 3FAP was retrieved from the RCSB protein data bank. Total 20 compounds were selected from the list of 113, obtained from LC-MS of Lalchandan. Further, in-silico molecular docking calculation was done by using YASARA software. Drug-likeness and molecular property of best-docked compounds were checked by using Lipinski rule of five and Admet SAR server. Result: Five compounds showed interaction with mTOR protein. Out of these Santalin A showed the best interaction with binding energy 11.453[kcal/mol] and dissociation constant 4025.6841 [pM]. Further, the Lipinski drug-likeness and admetSAR results also showed that Santalin A has good optimal oral bioavailability, non-carcinogenic and no toxic effect, suggesting all drug-like properties as compared to standard drug Rapamycin. Conclusion: Santalin-A, can be taken up as a potential lead compound for biological testing for developing a new drug for diabetic nephropathy, acting via mTOR signaling inhibition pathway.

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A database on endemic plants at Tirumala hills in India

Cited by 22 publications

References 4 publications

Entomophily, ornithophily and anemochory in the self-incompatible Boswellia ovalifoliolata Bal. & Henry (Burseraceae), an endemic and endangered medicinally important tree species

Entomophily, ornithophily and anemochory in the self-incompatible Boswellia ovalifoliolata Bal. & Henry (Burseraceae), an endemic and endangered medicinally important tree species

Genomic DNA Isolation and Purification of Two Endemic Medicinal Plants (Pterocarpus Santalinus Linn.F & Pimpinella Tirupatiensis Bal&Subr) of Seshachalam Hills, Tirumala.

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