Dispatching rules are generally useful for scheduling jobs in flexible manufacturing systems (FMSs). However, the appropriateness of these rules relies heavily on the condition of the system; thus, there is no single rule that always outperforms others. In this state of affairs, diverse machine-learning technology offers an effective approach for dynamic scheduling, as it allows managers to identify the most suitable rule at each moment. Nonetheless, various machine-learning algorithms may provide diverse recommendations. The main objective of this study is to implement FMS scheduling using intelligent hybrid learning algorithms with metaheuristic improvements. The developed model involves three phases: feature extraction, optimal weighted feature extraction, and prediction. After the benchmark datasets for the FMS are gathered, feature extraction is performed using t-distributed stochastic neighbor embedding, linear discriminant analysis, linear square regression, and higher-order statistical features. Further, an optimal weighted feature extraction method is developed to select the optimal features with less correlation using the improved lion algorithm (LA), which is called the modified nomadic-based LA (MN-LA). Finally, the optimally selected weighted features are subjected to a hybrid learning algorithm with the integration of a fuzzy classifier and a deep belief network (DBN). For improving the prediction model, the membership function of the fuzzy classifier is optimized using the proposed MN-LA. Moreover, the activation function and the number of hidden neurons in the DBN are optimized using the MN-LA. The main objective of the optimized hybrid classifier is to enhance prediction accuracy. The experimental results indicate the effectiveness of the proposed heuristicbased scheduling method for FMSs.