A deadly aversion to pork

Fournier, Pierre‐Edouard; Thuny, Franck; Grisoli, Dominique; Lépidi, Hubert; Vitte, J.; Casalta, Jean‐Paul; Weiller, Pierre‐Jean; Habib, Gilbert; Raoult, Didier

doi:10.1016/s0140-6736(11)60021-4

Cited by 25 publications

(19 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 2011, Fournier and colleagues reported a case of recurrent mitral valve vegetation requiring four tissue valve replacements. 3 Post-mortem examination demonstrated eosinophilic infiltration of the valve and progressively increasing IgE levels, including to pork, although alpha-gal IgE was never tested. Most recently, three patients with known alpha-gal IgE titers experienced perioperative anaphylactic reactions after implantation of bioprosthetic valves.…”

Section: Discussionmentioning

confidence: 99%

“…The experience of alpha‐gal allergy in the context of bioprosthetic valves is extremely limited. In 2011, Fournier and colleagues reported a case of recurrent mitral valve vegetation requiring four tissue valve replacements . Post‐mortem examination demonstrated eosinophilic infiltration of the valve and progressively increasing IgE levels, including to pork, although alpha‐gal IgE was never tested.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Premature Bioprosthetic Aortic Valve Degeneration Associated with Allergy to Galactose‐Alpha‐1,3‐Galactose

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Premature Bioprosthetic Aortic Valve Degeneration Associated with Allergy to Galactose‐Alpha‐1,3‐Galactose

et al. 2016

View full text Add to dashboard Cite

show abstract

“…• Gelatin including capsules 48 , tablets 36 , suppositories, colloids 49 , and vaccines 50,51 • Collagen including corneal shields 52 , hemostatic agents 47 or other scaffolds • Magnesium stearate 36 • Mammalian derived heart valves 34,35,54 Although some health care providers observe that AGS patients may tolerate administration of gal containing therapeutics, these patients require unique and special care that places additional economic burden while exposing them to potential harm 55,56 .…”

Section: Clinical Implications Of Gal In Human Therapeutic Productsmentioning

confidence: 99%

“…More concerning for AGS patients receiving heart valves is that the acute IgE response has been linked to immediate post-operative anaphylaxis, 35 blood culture negative endocarditis, 54,65 and rapid destruction of the valve 34,54 . In addition, anaphylaxis during other cardiac procedures have been attributed to administration of heparin (derived from porcine intestines) or the use of the hemostatic agent Gelfoam (derived from porcine skin) 36 56 47 .…”

Section: Cardiovascular Medicinal Productsmentioning

confidence: 99%

Alpha-gal syndrome: Implications for cardiovascular disease

Bianchi¹,

Walters²,

Fitch

et al. 2020

gcsp

View full text Add to dashboard Cite

Alpha-gal syndrome (AGS) refers to a potentially life-threatening allergy to the molecule galactose-α1,3galactose (gal), which is expressed on most mammalian tissues but, importantly, is not expressed by humans. This syndrome can manifest as an allergic reaction to mammalian meat products, but other sources of mammalian tissue can also provoke an immune response, including injectable and implantable medical products. This syndrome has been linked to coronary atherosclerosis, and medical products that express gal are routinely used in cardiology and cardiac surgery. This article seeks to discuss potential implications of alpha syndrome as it relates to cardiovascular health and to heighten awareness in the cardiovascular community about this emerging public health issue. Prevalence of galactose-α1,3-galactoseMost mammalian species (including New World monkeys, cows, pigs, goats, horses, sheep, rabbits and mice) express the galactose-α1,3-galactose (gal) disaccharide sugar on cells and tissue surfaces 1-4 . Gal expression results from the catalytic activity of the α1,3-galactosyltransferase enzyme encoded by the glycoprotein α1,3galactosyltransferase gene (GGTA1) 1-3, 5 . Certain mammalian species, such as catarrhines (humans, apes, and Old World monkeys), do not have a functional GGTA1 gene 6-8 and correspondingly do not express gal 1, 3, 4 . Additionally, gal has been documented to be absent in fish, amphibians, reptiles, and birds 3,9,10 . The function of gal is unknown 3 , but it is clearly not essential for survival 1, 3 .

show abstract

“…Bu şekilde standardize yöntemlerin kullanıldığı çalışmalarda, ameliyat sonrası gelişen İE olgularında mantarların sıklığının fazla olduğu, birçok kültür-negatif hastada kanser veya otoimmün hastalıklarla ilişkili nontrombotik non-bakteriyel endokarditin söz konusu olduğu bulunmuştur (56,57). Ayrıca domuz kaynaklı biyoprotez kapak takılmış hastalarda, domuz proteinlerine karşı alerji sonucu gelişen yineleyen ve ateşsiz bir kültür-negatif hastalık da tanımlanmıştır (58). İE'li hastalarda etkene yönelik tetkikler dışında tam idrar tetkiki, C-reaktif protein (CRP), romatoid faktör (RF), tam kan sayımı, eritrosit sedimantasyon hızı (ESR) da tanıda yardımcı testlerdir.…”

Section: Streptokoklarunclassified

Infective Endocarditis: An Update

Şimşek-Yavuz¹

2015

Klimik Dergisi

8
0
2
0

View full text Add to dashboard Cite

İnfektif endokardit (İE), çok uzun yıllardan beri bilinen bir hastalık olmasına ve tanı ve tedavisinde birçok gelişmeler sağlanmasına karşın, tüm tıbbi olanaklara erişimin mümkün olduğu gelişmiş ülkelerde bile %20 gibi yüksek bir mortalite hızı sergiler. Ülkemizde ise bu hız %30'u bulmaktadır. İE'nin tanısı, tedavisi ve önlenmesi konusunda yayımlanmış çok fazla sayıda rehber vardır. Ancak günlük klinik pratikte, bu rehberlere uyum konusunda önemli sorunlar yaşanmakta, bu da hasta prognozunu olumsuz yönde etkilemektedir. İE'li hastaların tanı ve tedavisi için infeksiyon hastalıkları ve klinik mikrobiyoloji, kardiyoloji ve kardiyovasküler cerrahi uzmanlarının birlikte çalışması (İE ekibi) ve ortak bir yaklaşım oluşturması, başvurulan hekimden bağımsız olarak, her hastaya standard bir tedavi uygulanmasını sağlayabilir. Bu derlemede, İE epidemiyolojisi, etkenleri, tanısı, tedavisi ve önlenmesi konusunda ülkemizde ve dünyadaki mevcut durum, güncel yayınlar ve rehberler eşliğinde değerlendirilmiş, İE'li hasta bakımının daha iyi hale getirilebilmesi için öneriler sunulmuştur.

show abstract

A deadly aversion to pork

Cited by 25 publications

References 5 publications

Premature Bioprosthetic Aortic Valve Degeneration Associated with Allergy to Galactose‐Alpha‐1,3‐Galactose

Premature Bioprosthetic Aortic Valve Degeneration Associated with Allergy to Galactose‐Alpha‐1,3‐Galactose

Alpha-gal syndrome: Implications for cardiovascular disease

Infective Endocarditis: An Update

Contact Info

Product

Resources

About