A Decisive Period in the Antibiotic Prophylaxis of Cutaneous Lesions Caused by Bacteroides fragilis in Guinea Pigs

Antibiotic prophylaxis and third molar surgery

“…16,[19][20] Post-operative complications and prophylactic antiobiotics There is a considerable volume of evidence that advocates antibiotics for the prevention of infection following third molar surgery. 13,[21][22][23][24][25][26] Other articles do not specifically comment on infection rates but support the use of antibiotics on the basis of reduced postoperative complications. 27 Improvement from trismus, reduction of pain and swelling with improved healing are outcomes that have been used to assess the success of antibiotics.…”

“…Considering the value of preoperative parenteral antibiotics, a body of evidence favours their use [21][22][23]41 in third molar surgery. Extensive studies of third molar removal in patients with fully or partial bony infection of third molars favour the use of prophylactic parenteral antibiotics, since lower postoperative infection rates have been reported.…”

Revisões sistemáticas de antibioticoprofilaxia em cesarianas

“…Os resultados do ensaio de Burke 8 , com porquinhos-da-Índia, indicaram que o antimicrobiano deve estar circulando e presente nos tecidos no momento em que ocorrer a incisão e a contaminação bacteriana do sítio operatório. Em 1980, Shapiro et al 9 confirmaram os achados de Burke, encontrando diferença significativa entre o diâmetro da lesão dos animais que receberam o antimicrobiano 1 hora antes da inoculação intradérmica de bactérias e o daqueles que receberam a droga 4 horas após a inoculação ou não receberam a droga. Dois estudos bem desenhados, em humanos, apóiam os achados relativos à importância da cobertura antimicrobiana no momento da cirurgia 10,11 .…”

“…Diferença de taxas: modelo de efeitos fixos DT: 6,1 (1,(2)(3)(4)(5)(6)(7)(8)(9)(10)9) DT: 3,0 (-1,0-7,0)…”

Plasma and Tissue Concentrations of Ceforanide and Cefazolin in Women Undergoing Hysterectomy

“…One factor that determines the efficacy of perioperative antimicrobial prophylaxis is the presence of antibiotics in tissues at the time of surgical incision and of contamination of the wound. Propyhlactic antibiotics should be adminis tered prior to beginning surgery to be opti mally effective [3,4], Whether persistence of measurable antibiotic levels in tissues throughout the duration of surgical proce dure is necessary is not known. Platt et al…”