A Decreased Absolute Number of Treg Cells in Patients with Active Rheumatoid Arthritis is Associated with Elevated Serum Osteopontin Levels with Disease Progression

Xie, Jinchen; Wang, Jia; Bai, Huan-Huan; He, Jiaojiao; Jia, R; Wang, Xia; Zhang, Wenqi; Zhao, Xiangcong; Zhang, Xiancheng; Liu, Guangying; Li, Xiaofeng

doi:10.1007/s12325-022-02171-9

Cited by 3 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, OPN deficiency prevents joint swelling and destruction as well as cartilage proteoglycan loss in anti-type II collagen antibody-induced arthritis in mice (46). In humans, this mediator resulted higher in patients with active RA versus non active disease and paralleled the lowest proportions of Treg cells, suggesting its potential direct role in the dysregulation of Treg/T effector cells balance (47).…”

Section: New Findings In Adaptative Immunitymentioning

confidence: 99%

Pathogenesis of rheumatoid arthritis: one year in review 2023

Mariani,

Martelli,

Pistone

et al. 2023

Clinical and Experimental Rheumatology

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by local and systemic inflammation. The complex interplay between immune cells and soluble mediators leads to the induction and perpetuation of aberrant inflammatory and autoimmune responses. The research carried out in the last year in the field of RA enabled the identification of new mechanisms involved in the pathogenesis of the disease and therefore unmasked new potential therapeutic targets. In this review article we summarised the new insights into RA pathogenesis from original research articles published in the last year.

show abstract

Section: New Findings In Adaptative Immunitymentioning

confidence: 99%

Pathogenesis of rheumatoid arthritis: one year in review 2023

Mariani,

Martelli,

Pistone

et al. 2023

Clinical and Experimental Rheumatology

View full text Add to dashboard Cite

show abstract

“…Luukkonen and colleagues elucidated that when TRAcP 5B is produced in insufficient quantities in synovial tissue, it led to an excessive concentration of p-OPN associated with OC activation, cartilage degradation, and activation of immune cells [ 140 ]. In a recent study, Xie et al noticed that the highest sOPN serum levels were observed in RA patients in an active phase of the disease and correlated negatively with Treg absolute counts [ 141 ].…”

Section: Osteopontin: Could It Be Considered a Common Denominator In ...mentioning

confidence: 99%

Osteopontin: A Bone-Derived Protein Involved in Rheumatoid Arthritis and Osteoarthritis Immunopathology

et al. 2023

View full text Add to dashboard Cite

Osteopontin (OPN) is a bone-derived phosphoglycoprotein related to physiological and pathological mechanisms that nowadays has gained relevance due to its role in the immune system response to chronic degenerative diseases, including rheumatoid arthritis (RA) and osteoarthritis (OA). OPN is an extracellular matrix (ECM) glycoprotein that plays a critical role in bone remodeling. Therefore, it is an effector molecule that promotes joint and cartilage destruction observed in clinical studies, in vitro assays, and animal models of RA and OA. Since OPN undergoes multiple modifications, including posttranslational changes, proteolytic cleavage, and binding to a wide range of receptors, the mechanisms by which it produces its effects, in some cases, remain unclear. Although there is strong evidence that OPN contributes significantly to the immunopathology of RA and OA when considering it as a common denominator molecule, some experimental trial results argue for its protective role in rheumatic diseases. Elucidating in detail OPN involvement in bone and cartilage degeneration is of interest to the field of rheumatology. This review aims to provide evidence of the OPN’s multifaceted role in promoting joint and cartilage destruction and propose it as a common denominator of AR and OA immunopathology.

show abstract

“…Decreased levels of circulating Tregs have been observed in patients with juvenile idiopathic arthritis ( 63 , 64 ), hepatitis C virus associated mixed cryoglobulinemia ( 65 ), autoimmune liver disease ( 66 ), and SLE ( 67 , 68 ), and lower levels of these cells were correlated with high disease activity and worse prognosis. More recently, fewer Tregs were identified in individuals with rheumatoid arthritis compared to healthy controls and were similarly correlated with higher disease activity ( 69 ). However, it must be noted that reduced numbers of Tregs is not uniform across autoimmune diseases, and discrepancies may be due to variability in the markers used to identify Tregs.…”

Section: The Role Of Foxp3+ Tregs In Autoimmunity and Solid Organ Tra...mentioning

confidence: 99%

Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation

et al. 2022

View full text Add to dashboard Cite

Regulatory T cells (Tregs) are critical for tolerance in humans. The exact mechanisms by which the loss of peripheral tolerance leads to the development of autoimmunity and the specific role Tregs play in allograft tolerance are not fully understood; however, this population of T cells presents a unique opportunity in the development of targeted therapeutics. In this review, we discuss the potential roles of Foxp3+ Tregs in the development of tolerance in transplantation and autoimmunity, and the available data regarding their use as a treatment modality.

show abstract

A Decreased Absolute Number of Treg Cells in Patients with Active Rheumatoid Arthritis is Associated with Elevated Serum Osteopontin Levels with Disease Progression

Cited by 3 publications

References 30 publications

Pathogenesis of rheumatoid arthritis: one year in review 2023

Pathogenesis of rheumatoid arthritis: one year in review 2023

Osteopontin: A Bone-Derived Protein Involved in Rheumatoid Arthritis and Osteoarthritis Immunopathology

Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation

Contact Info

Product

Resources

About