BackgroundMost children with cancer will require a central venous access device (CVAD) to administer cancer treatment. A commonly used CVAD is a tunnelled cuffed centrally inserted central catheter (TC‐CICC). There is little information available to guide best practice when removing this type of CVAD. At our institution, TC‐CICCs are removed by using either the traction or dissection methods. This study will describe the outcomes associated with each technique.Methods/resultsA retrospective cohort study was undertaken at a quaternary children's hospital in Melbourne, Australia. Data related to characteristics of TC‐CICC removal success, post‐removal complications and an economic evaluation were carried out. There were 149 patients who underwent traction removal and 100 who had their TC‐CICC removed using the dissection technique. In the traction group, 136/149 (91%) patients had their device successfully removed on the first attempt, whereas 99/100 (99%) were removed on the first attempt with dissection. Of the 136 successful traction removals, cuff status was documented in 72 cases. The cuff remained in situ in 46/72 (64%) cases, and six of 72 (8%) patients experienced a complication. There were no documented cases of cuff retention in the dissection group. In the 2019–2020 financial year, the estimated average cost of traction removal was A$387, whereas the estimated average cost of day case surgery was A$2560.ConclusionThis study has highlighted that the traction technique is a safe, efficient and cost‐effective approach to TC‐CICC removal. Further research is required to understand the patient and family experience of TC‐CICC removal.