A deeper view of transmitted/founder viruses using 454 whole genome deep sequencing

Tully, Damien C.; Power, KA; Bedard, Hunter E.; Boutwell, CL; Charlebois, Patrick; Ryan, Eoin; Lennon, NJ; Altfeld, Marcus; Henn,; Allen, Todd M.

doi:10.1186/1742-4690-9-s2-o58

Cited by 2 publications

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“…Multiple low-dose challenge models closely mimic a heterosexual exposure to HIV because of the transmission of a small number of founder viruses from the challenge stock [11, 12]. In men who have sex with men (MSM), however, multiple founder viruses are often transmitted during the time of initial exposure [12, 13]. Since a greater number of founder viruses are transmitted during a high-dose challenge, this model may more accurately predict the efficacy of vaccines to prevent the transmission of HIV in MSM.…”

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confidence: 99%

Antigenic requirement for Gag in a vaccine that protects against high-dose mucosal challenge with simian immunodeficiency virus

et al. 2015

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We reported previously on a vaccine approach that conferred apparent sterilizing immunity to SIVsmE660. The vaccine regimen employed a prime-boost using vectors based on recombinant vesicular stomatitis virus (VSV) and an alphavirus replicon expressing either SIV Gag or SIV Env. In the current study, we tested the ability of vectors expressing only the SIVsmE660 Env protein to protect macaques against the same high-dose mucosal challenge. Animals developed neutralizing antibody levels comparable to or greater than seen in the previous vaccine study. When the vaccinated animals were challenged with the same high-dose of SIVsmE660, all became infected. While average peak viral loads in animals were slightly lower than those of previous controls, the viral set points were not significantly different. These data indicate that Gag, or the combination of Gag and Env are required for the generation of apparent sterilizing immunity to the SIVsmE660 challenge.

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Section: Introductionmentioning

confidence: 99%

Antigenic requirement for Gag in a vaccine that protects against high-dose mucosal challenge with simian immunodeficiency virus

et al. 2015

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Characteristics and diversity of endophytic bacteria in moso bamboo (Phyllostachys edulis) based on 16S rDNA sequencing

et al. 2017

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To understand the diversity and distribution of endophytic bacteria in moso bamboo (Phyllostachys edulis), we used 16S rDNA sequencing to investigate the characteristics and diversity of endophytic bacteria in different moso bamboo tissues. After 454 pyrosequencing, we obtained 141,269 sequences from seven moso bamboo tissue samples. The taxonomic origins of unique sequences were identified using RDP classifier. The results showed that these sequences belonged to 26 bacterial orders, including the Actinomycetales, Rickettsiales, Burkholderiales, Enterobacteriales, and Rhizobiales. Among these, Enterobacteriales was widely found in all bamboo tissues. Endophytic bacterial communities differed between the moso bamboo shoot and pole. With continuous growth and development, the number of endophytic species in the moso bamboo pole increased gradually.

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A deeper view of transmitted/founder viruses using 454 whole genome deep sequencing

Abstract: Tully et al.: A deeper view of transmitted/founder viruses using 454 whole genome deep sequencing. Retrovirology 2012 9(Suppl 2):O58.

Cited by 2 publications

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Antigenic requirement for Gag in a vaccine that protects against high-dose mucosal challenge with simian immunodeficiency virus

Antigenic requirement for Gag in a vaccine that protects against high-dose mucosal challenge with simian immunodeficiency virus

Characteristics and diversity of endophytic bacteria in moso bamboo (Phyllostachys edulis) based on 16S rDNA sequencing

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