A dentin hypersensitivity treatment using highly stable photothermal conversion nanoparticles

Abstract

Most of currently available commercial photothermal agents suffer from the issues in terms of photothermal instability and low photothermal conversion efficiency (PCE), which indeed impair their practical applications in disease...

Quantitative Comparison of the Light-to-Heat Conversion Efficiency in Nanomaterials Suitable for Photothermal Therapy

“…Photothermal conversion nanoparticles, referred to as nanoheaters (NHs), allow one to increase the temperature of their surroundings in a spatially localized and contactless manner, which opens new opportunities in many areas. For example, optical NHs can be applied in technology areas such as solar light energy harvesting, photocatalysts or photoactuators, as well as in biotechnology in the treatment of dentin hypersensitivity or antibacterial therapy. , Additionally, NHs have shown great prospects in cancer photothermal therapy (PTT), especially after the first report of the successful application of NHs in clinical trials for the treatment of prostate cancer . Depending on the temperature range, the PTT takes advantage of the fact that, unlike healthy cells, cancer cells are specifically more sensitive to overheating beyond 41 °C (hyperthermia range), or the affected cells are damaged by thermal ablation (temperatures above 48 °C) …”

A cationic conjugated polymer with high 808 nm NIR-triggered photothermal conversion for antibacterial treatment

“…Thus, the photothermal conversion efficiency was calculated to be 71.1%, which was higher than that of existing photothermal materials. 33,37,45,46 Presumably, the high photothermal conversion of PDTPBT may benefit from their zero radiative transition rates of the high electron-deficiency benzothiadiazole. A strong bipolaron that can decay to a phonon band may result from it, producing the thermal effect via nonradiative transition.…”

Phototheranostic Nanoagents for Imaging‐Guided Treatment of Oral Cancer†

“…[ 39‐41,118‐121 ] During the PTT, the phototheranostic nanoagents absorb light energy and convert it into heat energy, which destroys cancer cells. [ 39‐41,121‐125 ] Notably, heating up process caused the tissue surroundings to vibrate during PTT, generating a PA signal, so the PT and PA signals were in a concomitant state. In addition, according to the Jablonski energy level diagram, the PT signal was generated by the nonradiative transition of excited state energy.…”