A detailed analysis of the effect of repetitive transcranial magnetic stimulation on negative symptoms of schizophrenia: A double-blind trial

Přikryl, Radovan; Ustohal, Libor; Kučerová, Hana Přikrylová; Kašpárek, Tomáš; Venclíková, Simona; Vrzalová, Michaela; Češková, Eva

doi:10.1016/j.schres.2013.06.015

Cited by 57 publications

(46 citation statements)

References 34 publications

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“…It has also been found that high-frequency rTMS applied over the left prefrontal cortex (PFC) increases brain perfusion, and thus the metabolism of this region, whereas low-frequency rTMS has the opposite effect [4].…”

Section: Tms Principles Parameters and Mechanism Of Actionmentioning

confidence: 99%

“…A number of double-blind studies also proved a statistically significant decrease in the intensity of negative schizophrenia symptoms when current antipsychotic treatment was augmented with rTMS; the actual clinical significance of this procedure is disputed [4].…”

Section: Negative Symptoms and Rtms-summarymentioning

confidence: 99%

“…Prikryl et al analyzed negative symptoms influenced with rTMS using five domains of SANS (affective flattening/blunting, alogia, avolition/apathy, anhedonia, and impaired attention). The stimulation improved all domains, except for alogia [4]. To improve the results with rTMS, the definition and the prediction of responders are needed.…”

Section: Future Directionsmentioning

confidence: 99%

See 2 more Smart Citations

Transcranial Magnetic Stimulation in Schizophrenia

Ustohal¹,

Svěrák²,

Albrechtová³

et al. 2016

Schizophrenia Treatment - The New Facets

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Transcranial magnetic stimulation (TMS) is a method that can be used in neurophysiological research of schizophrenia and in the treatment of some symptoms or syndromes of this mental disorder. The most important indications for TMS (or repetitive TMSrTMS) are the negative symptoms of schizophrenia and auditory hallucinations. Other less proven indications include cognitive deficit, especially working memory. This text summarizes general knowledge about (r)TMS and its use in schizophrenia. According to recent experiences, TMS is a very promising experimental and therapeutic method, but it needs further research for its optimized use.

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Section: Tms Principles Parameters and Mechanism Of Actionmentioning

confidence: 99%

Section: Negative Symptoms and Rtms-summarymentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

See 1 more Smart Citation

Transcranial Magnetic Stimulation in Schizophrenia

Ustohal¹,

Svěrák²,

Albrechtová³

et al. 2016

Schizophrenia Treatment - The New Facets

Self Cite

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show abstract

“…The active rTMS group demonstrated a statistically significantly higher reduction in all domains of negative symptoms of schizophrenia. They reported that high-frequency stimulation of the left DLPFC may represent an efficient augmentation of antipsychotics in relieving the negative symptoms of schizophrenia [30].…”

Section: Effect Of Rtms On Negative Symptomsmentioning

confidence: 99%

Use of Repetitive Transcranial Magnetic Stimulation in Treatment of Negative Symptoms of Schizophrenia

Sayar¹,

Bulut²,

Tarhan³

2015

J Neurol Neurol Sci Disord

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“…In addition, TMS has been considered to be a promising therapeutic method not only for others neuropsychiatric disorders [3] as well as neurological diseases [4][5][6][7][8][9][10][11][12]. The coils of the TMS device deliver a changing electrical current that produces a time-varying magnetic field perpendicular to the current passing through the coils.…”

Section: Introductionmentioning

confidence: 99%

Optimization of multiple coils immersed in a conducting liquid for half-hemisphere or whole-brain deep transcranial magnetic stimulation: A simulation study

Sousa

Almeida

Miranda

et al. 2014

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Abstract-Transcranial magnetic stimulation (TMS) was proposed in 1985. Nevertheless, its wider use in the treatment of several neurologic diseases has been hindered by its inability to stimulate deep-brain regions. This is mainly due to the physical limiting effect arising from the presence of surface discontinuities, particularly between the scalp and air. Here, we present the optimization of a system of large multiple coils for whole-brain and half-hemisphere deep TMS, termed orthogonal configuration. COMSOL ® -based simulations show that the system is capable of reaching the very center of a spherical brain phantom with 58% induction relative to surface maximum. Such penetration capability surpasses to the best of our knowledge that of existing state of the art TMS systems. This induction capability strongly relies on the immersion of the stimulating coils and part of the head of the patient in a conducting liquid (e.g. simple saline solution). We show the impact of the presence of this surrounding conducting liquid by comparing the performance of our system with and without such liquid. In addition, we also compare the performance of the proposed coil with that of a circular coil, a figure-eight coil, and the H-coil. Finally, in addition to its whole-brain stimulation capability (e.g. potentially useful for prophylaxis of epileptic patients) the system is also able to stimulate mainly one brain hemisphere, which may be useful in stroke rehabilitation, among other applications.

show abstract

A detailed analysis of the effect of repetitive transcranial magnetic stimulation on negative symptoms of schizophrenia: A double-blind trial

Cited by 57 publications

References 34 publications

Transcranial Magnetic Stimulation in Schizophrenia

Transcranial Magnetic Stimulation in Schizophrenia

Use of Repetitive Transcranial Magnetic Stimulation in Treatment of Negative Symptoms of Schizophrenia

Optimization of multiple coils immersed in a conducting liquid for half-hemisphere or whole-brain deep transcranial magnetic stimulation: A simulation study

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