Objectives: This paper reports the effects of an energy and micronutrient supplementation on mental and motor development, activity and behavior under natural conditions of children classi®ed as iron de®cient anemic and iron replete. Design: Children were randomly assigned to two different nutritional supplements: (1) 12 mg iron either 1171 or 209 kJ; (2) 104 kJ 0 iron. Treatment lasted for 6 months. Setting: The sites were six tea plantations in Pangalengan, West Java. Subjects: Eighteen anemic subjects (hemoglobin`110 gaL; transferrin saturation (TS)`16%) and 18 matched (sex and age) controls (hemoglobin b 110 gaL; TS b 16%) were selected from a pool of children with the following characteristics: no chronic disease; length-for-age 7 1 standard deviation (s.d.) and weight-forlength between 71 and 72 s.d. of the median of the reference of the World Health Organization. Methods: Hemoglobin, ferritin, transferrin saturation and erythrocyte protoporphyrin were evaluated before and 6 months after treatment. The following psychological measurements were obtained at baseline and 2, 4 and 6 months later. Mental and motor development was evaluated with the Bayley Scale. Motor activity was measured by 4 h continuous observations at home and at day care centers. The interactions between the child and its social and physical environment were also evaluated during 4 h of observations. Results: Anemic children showed faster motor development and greater physical activity than the control children did. None of the other tests showed inter-group differences.