A device that operates within a self-assembled 3D DNA crystal

Hao, Yifei; Kristiansen, Martin; Sha, Ruojie; Birktoft, Jens J.; Hernandez, Carina; Mao, Chengde; Seeman, Nadrian C.

doi:10.1038/nchem.2745

Cited by 70 publications

(55 citation statements)

References 21 publications

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“…Seemana nd co-workers designed ad ynamic mechanism that functioned in a3 DD NA crystal based on strand displacement. [52] Ta na nd co-workersa chieved ar eversible assembly and disassembly of DNA nanoprism dimers anchored on fluid lipid bilayers of cell-mimicking giant vesicles. [53] Apart from the above examples, toehold-mediated strand displacementw as also employed to control the surface porosity or the open/closes tates of DNA nano-containers toward programmable cargo release.…”

Section: Category 2: Toehold-mediated Strandd Isplacementmentioning

confidence: 99%

Stimuli‐Responsive DNA Self‐Assembly: From Principles to Applications

Jin

et al. 2019

Chemistry A European J

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Stimuli‐responsive DNA self‐assembly shares the advantages of both designed stimuli‐responsiveness and the molecular programmability of DNA structures, offering great opportunities for basic and applied research in dynamic DNA nanotechnology. In this minireview, we summarize the most recent progress in this rapidly developing field. The trigger mechanisms of the responsive DNA systems are first divided into six categories, which are then explained with illustrative examples following this classification. Subsequently, proof‐of‐concept applications in terms of biosensing, in vivo pH‐mapping, drug delivery, and therapy are discussed. Finally, we provide some remarks on the challenges and opportunities of this highly promising research direction in DNA nanotechnology.

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Section: Category 2: Toehold-mediated Strandd Isplacementmentioning

confidence: 99%

Stimuli‐Responsive DNA Self‐Assembly: From Principles to Applications

Jin

et al. 2019

Chemistry A European J

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“…DNA tiles were widely used for self‐assembly into different shapes, 2D arrays, and even single crystals . Inorganic nanoparticles were also successfully inserted inside or attached around to build nanoclusters with accurate positioning of nanoparticles in desired places.…”

Section: Recruit Biological Nanoparticles Frames Into the Library Of mentioning

confidence: 99%

3D Lattice Engineering of Nanoparticles by DNA Shells

Tian

2019

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With the development of structural DNA nanotechnology, DNA has now far exceeded its original function: as a genetic code. It can, in principle, self‐assemble into desired shapes with accurate size. Moreover, it can perform as a functional linker to program other materials by grafting DNA onto these materials. Nanoparticles, both inorganic and organic, can now be programmatically assembled into complex 3D superlattices with high order when guided by DNA. By encoding functions into the as‐assembled nanoparticles, materials with excellent collective effects may be invented. Here, how nanoparticles with different shapes or functions are successfully fabricated into 3D lattices with the help of DNA shells coated on the surface and how scientists can produce desired lattices by design are reviewed. The cases to achieve dynamic superlattices of nanoparticles by affecting the environment where DNA survives are also discussed.

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“…In summary, we determined the crystal structure of a new rationally designed, self‐assembled DNA crystal with a six‐fold symmetric lattice. The programmable structure provides a valuable route towards the design of self‐assembled macromolecular 3D crystalline lattices with atomic precision and possesses a highly organized array of well‐defined cavities that could be suitable for future applications such as biocatalysis, biomolecular separation, and creation of dynamic devices …”

Section: Figurementioning

confidence: 99%

Self‐Assembly of a 3D DNA Crystal Structure with Rationally Designed Six‐Fold Symmetry

et al. 2018

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Programming self‐assembled designer DNA crystals with various lattices and functions is one of the most important goals for nanofabrication using nucleic acids. The resulting porous materials possess atomic precision for several potential applications that rely on crystalline lattices and cavities. Herein, we present a rationally designed and self‐assembled 3D DNA crystal lattice with hexagonal symmetry. In our design, two 21‐base oligonucleotides are used to form a duplex motif that further assembles into a 3D array. The interactions between the strands are programmed using Watson–Crick base‐pairing. The six‐fold symmetry, as well as the chirality, is directed by the Holliday junctions formed between the duplex motifs. The rationally designed DNA crystal provides a new avenue that could create self‐assembled macromolecular 3D crystalline lattices with atomic precision. In addition, the structure contains a highly organized array of well‐defined cavities that are suitable for future applications with immobilized guests.

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A device that operates within a self-assembled 3D DNA crystal

Cited by 70 publications

References 21 publications

Stimuli‐Responsive DNA Self‐Assembly: From Principles to Applications

Stimuli‐Responsive DNA Self‐Assembly: From Principles to Applications

3D Lattice Engineering of Nanoparticles by DNA Shells

Self‐Assembly of a 3D DNA Crystal Structure with Rationally Designed Six‐Fold Symmetry

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