A dietary pattern characterized by high consumption of whole-grain cereals and low-fat dairy products and low consumption of refined cereals is positively associated with plasma adiponectin levels in healthy women

Yannakoulia, Mary; Yiannakouris, Nikos; Melistas, Labros; Kontogianni, Meropi D.; Malagaris, Ioannis; Mantzoros, Christos S.

doi:10.1016/j.metabol.2008.01.027

Cited by 65 publications

(38 citation statements)

References 45 publications

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“…This is similar to the variance reported in recent population based diet studies [13]. On the other hand, prudent dietary patterns may affect circulating levels of adipocyte secreted hormones which are of major importance in mediating some of the changes observed [27, 28]. In addition, dietary patterns may also affect the development of lipohypertrophy and/or regional body composition changes, and adipose tissue changes may be equally or more important predictors of adipocytokines and/or metabolic abnormalities in these patients as they precede or coincide with the metabolic changes observed.…”

Section: Discussionsupporting

confidence: 86%

Adherence to Mediterranean diet is favorably associated with metabolic parameters in HIV-positive patients with the highly active antiretroviral therapy–induced metabolic syndrome and lipodystrophy

et al. 2009

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Objective-To investigate whether closer adherence to a Mediterranean dietary pattern is associated with metabolic aspects of the Highly Active Antiretroviral Therapy (HAART)-induced metabolic syndrome (fat redistribution, insulin resistance, dyslipidemia) in HIV positive patients. Design-Cross sectional study.Methods-227 HIV-infected patients were evaluated during a single outpatient visit to the General Clinical Research Center of Beth Israel Deaconess Medical Center. Usual dietary intake and physical activity habits were evaluated; the Mediterranean Diet Score (MedDietScore) was calculated. Dualenergy x-ray absorptiometry, CT findings anthropometrics and data from the study interviews and questionnaires were used for the assessment of body composition using specific criteria. A complete metabolic profile was available for all subjects.Results-In the entire study sample, a weak inverse association was found between insulin resistance, estimated using the homeostasis model (HOMA-IR), and MedDietScore (standardized β= -0.15, p = 0.03). Interaction models revealed that this was largely driven by an inverse association in patients with fat redistribution (FR) (standardized β = -0.13, p = 0.02). Moreover, MedDietScore was positively correlated with HDL-cholesterol (standardized β = 0.15, p = 0.01) and marginally negatively associated with circulating triglyceride levels (standardized β = -0.16, p = 0.13) in this group of patients. Conflicts of interest: NoneAuthors' contributions: Dr. Mantzoros designed this study. Drs. Tsiodras, Chimienti and Wadhwa collected the data. Ms. Poulia and Dr. Yannakoulia analyzed the dietary information, performed the statistical analysis and drafted the paper. Drs Mantzoros and Tsiodras contributed to subsequent revisions of the paper and to the responses to the reviewers' comments. Drs. Karchmer and Mantzoros secured funding for this study. All authors critically revised the manuscript and approved the final version submitted.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptMetabolism. Author manuscript; available in PMC 2010 June 1.

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Section: Discussionsupporting

confidence: 86%

Adherence to Mediterranean diet is favorably associated with metabolic parameters in HIV-positive patients with the highly active antiretroviral therapy–induced metabolic syndrome and lipodystrophy

et al. 2009

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“…The present study is limited by the potential for unmeasured confounders such as dietary habits. A diet high in whole grain cereals is positively correlated with circulating levels of total adiponectin, but to our knowledge dietary habits have not been correlated with circulating levels of the adiponectin multimers 45. Other potential unmeasured confounders include physical activity, Helicobacter pylori infection, and the use of non-steroidal anti-inflammatory drugs.…”

Section: Discussionmentioning

confidence: 87%

Association of adiponectin multimers with Barrett's oesophagus

Rubenstein

Kao

Madanick

et al. 2009

Gut

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Objective Barrett’s oesophagus is associated with abdominal obesity. Adiponectin is a peptide that is secreted from adipocytes and circulates in three multimeric forms: low molecular weight (LMW), middle molecular weight (MMW), and high molecular weight (HMW). The anti-inflammatory effects of adiponectin are specific to individual multimers, with LMW being most anti-inflammatory. We postulated that circulating levels of adiponectin and its multimers would be associated with the risk of Barrett’s oesophagus. Design Cross-sectional study. Setting Outpatient clinic in North Carolina, USA. Patients Cases of Barrett’s oesophagus and controls undergoing upper endoscopy for gastro-oesophageal reflux disease (GORD). Main outcome measures Adjusted odds ratios of plasma adiponectin levels and its multimers for Barrett’s oesophagus. Results There were 112 cases of Barrett’s oesophagus and 199 GORD controls. Total adiponectin was not associated with Barrett’s oesophagus (3rd tertile vs 1st tertile adjusted odds ratio (aOR) = 0.88; 95% confidence interval (CI) = 0.44 to 1.78). High levels of LMW adiponectin were associated with a decreased risk of Barrett’s oesophagus (3rd tertile vs 1st tertile aOR = 0.33; 95% CI, 0.16 to 0.69), and a high LMW/total ratio appeared particularly inversely associated with Barrett’s oesophagus (3rd tertile vs 1st tertile aOR = 0.27; 95% CI, 0.13 to 0.58). Conclusions High levels of LMW adiponectin are associated with a decreased risk of Barrett’s oesophagus among patients with GORD. Further human studies are required to confirm these findings, and in vitro studies are needed to understand if there is a mechanism whereby adiponectin may affect Barrett’s metaplasia.

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“…There are studies showing that a greater adherence to MD is associated with increased adiponectin levels in diabetic [44] and healthy women [45]. We hypothesized that the +276T/G adiponectin gene variant may be interacting in this association and consequently modifying body weight regulation.…”

Section: Discussionmentioning

confidence: 94%

A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change

et al. 2009

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A dietary pattern characterized by high consumption of whole-grain cereals and low-fat dairy products and low consumption of refined cereals is positively associated with plasma adiponectin levels in healthy women

Cited by 65 publications

References 45 publications

Adherence to Mediterranean diet is favorably associated with metabolic parameters in HIV-positive patients with the highly active antiretroviral therapy–induced metabolic syndrome and lipodystrophy

Adherence to Mediterranean diet is favorably associated with metabolic parameters in HIV-positive patients with the highly active antiretroviral therapy–induced metabolic syndrome and lipodystrophy

Association of adiponectin multimers with Barrett's oesophagus

A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change

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