A dimensional approach to the neuronal correlates of anxiety, depression, and perfectionism: A transdiagnostic dissociation of error-related brain activity

Macedo, Inês; Pasion, Rita; Barbosa, Fernando; Ferreira‐Santos, Fernando

doi:10.1016/j.bbr.2021.113271

Cited by 10 publications

(26 citation statements)

References 68 publications

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“…While our null findings might conceivably be attributable to insufficient sample size, it is also possible that internalizing-related processes indexed by these ERPs are disorder-specific rather than general. Recent evidence indicates, for example, that ERP modulation may relate more to symptom manifestations of internalizing at lower levels of the HiTOP hierarchy (e.g., anhedonia, worry, rumination, error sensitivity) than to general proneness to internalizing problems (Bruder et al, 2002; Klawohn et al, 2020; Macedo et al, 2021; Moser et al, 2013; Santopetro et al, 2022; Saunders & Inzlicht, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…A modified version of the arrowhead Flanker Task was administered. It included a threat contingency for incorrect responses (Macedo et al, 2021; Pasion et al, 2018), consisting of an aversive white noise (50% probability) delivered within a random 5,000–10,000 ms interval following errors or omissions, succeeded by a black-silent display (1,000 ms) to reduce punishment-related brain activity. During the punishment delay, an error-threat message [ERROR!]…”

Section: Methodsmentioning

confidence: 99%

“…Thus, reduced ERN may essentially represent a transdiagnostic liability indicator of general proneness to impulse control problems, reflected by the broad externalizing factor. Notably, some prior studies have reported enhanced ERN in relation to internalizing psychopathology problems, but effect sizes appear to be more modest, especially when considering the diversity of internalizing expressions and when correcting for publication bias (Macedo et al, 2021;Pasion & Barbosa, 2019;Saunders & Inzlicht, 2020). Associations of P3 with internalizing conditions have been more mixed as well, with some studies reporting reduced P3 amplitude in distress disorders but enhanced P3 amplitude in relation to fear disorders (see Watson et al, 2022 for a review).…”

Section: P3 and Ern As Neural Indicators Of Externalizing Pronenessmentioning

confidence: 99%

“…Based on previous factor analytic work suggesting that variants of the P3 and ERN load onto separate ERP factors indicative of distinct processes (Burwell et al, 2016; Ribes-Guardiola et al, 2020), we hypothesized that each ERP factor would show unique predictive relations with broad externalizing factor.Considering that P3 and ERN seem to operate as neurophysiological indicators of general susceptibility to externalizing psychopathology (Lutz et al, 2021; Pasion & Barbosa, 2019; Patrick et al, 2006; Yancey et al, 2013), we predicted that specific problem dimensions loading onto the broad externalizing factor would not relate significantly to either ERP factor after accounting for the broad externalizing factor.Given that internalizing problems correlate positively with externalizing proneness (Caspi et al, 2014; Caspi & Moffitt, 2018), we also performed some additional analyses for testing associations between the two ERP factors with internalizing psychopathology. Given the diversity of methods and findings for these ERPs across the internalizing spectrum (Macedo et al, 2021; Pasion & Barbosa, 2019; Saunders & Inzlicht, 2020), we did not have specific hypotheses for this domain, and our analyses were exploratory in this regard.…”

Section: P3 and Ern As Neural Indicators Of Externalizing Pronenessmentioning

confidence: 99%

“…Given that internalizing problems correlate positively with externalizing proneness (Caspi et al, 2014; Caspi & Moffitt, 2018), we also performed some additional analyses for testing associations between the two ERP factors with internalizing psychopathology. Given the diversity of methods and findings for these ERPs across the internalizing spectrum (Macedo et al, 2021; Pasion & Barbosa, 2019; Saunders & Inzlicht, 2020), we did not have specific hypotheses for this domain, and our analyses were exploratory in this regard.…”

Section: P3 and Ern As Neural Indicators Of Externalizing Pronenessmentioning

confidence: 99%

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Modeling relations between event-related potential factors and broader versus narrower dimensions of externalizing psychopathology.

Pasion¹,

Ribes-Guardiola²,

Patrick³

et al. 2023

Journal of Psychopathology and Clinical Science

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The organization of the Hierarchical Taxonomy of Psychopathology (HiTOP) model provides unique opportunities to evaluate whether neural risk measures operate as indicators of broader latent liabilities (e.g., externalizing proneness) or narrower expressions (e.g., antisociality and alcohol abuse). Following this approach, the current study recruited a sample of 182 participants (54% female) who completed measures of externalizing psychopathology (also internalizing) and associated traits. Participants also completed three tasks (Flanker-No Threat, Flanker-Threat, and Go/No-Go tasks) with event-related potential (ERP) measurement. Three variants of two research domain criteria (RDoC)-based neurophysiological indicators—P3 and error-related negativity (ERN)—were extracted from these tasks and used to model two latent ERP factors. Scores on these two ERP factors independently predicted externalizing factor scores when accounting for their covariance with sex—suggesting distinct neural processes contributing to the broad externalizing factor. No predictive relation with the broad internalizing factor was found for either ERP factor. Analyses at the finer-grained level revealed no unique predictive relations of either ERP factor with any specific externalizing symptom variable when accounting for the broad externalizing factor, indicating that ERN and P3 index general liability for problems in this spectrum. Overall, this study provides new insights about neural processes in externalizing psychopathology at broader and narrower levels of the HiTOP hierarchy.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: P3 and Ern As Neural Indicators Of Externalizing Pronenessmentioning

confidence: 99%

Section: P3 and Ern As Neural Indicators Of Externalizing Pronenessmentioning

confidence: 99%

Section: P3 and Ern As Neural Indicators Of Externalizing Pronenessmentioning

confidence: 99%

See 3 more Smart Citations

Modeling relations between event-related potential factors and broader versus narrower dimensions of externalizing psychopathology.

Pasion¹,

Ribes-Guardiola²,

Patrick³

et al. 2023

Journal of Psychopathology and Clinical Science

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Explaining Brain-Behavior Relations: Inhibitory Control as an Intermediate Phenotype Between the N2 ERP and the Externalizing Spectrum in Childhood

Hosch,

Swanson,

Harris

et al. 2024

Res Child Adolesc Psychopathol

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Neurobehavioral Mechanisms of Comorbidity in Internalizing and Externalizing Psychopathology: An RDoC Multimethod Assessment

Pasion

Macedo

Paiva

et al. 2023

J Psychopathol Behav Assess

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This study links different-modality indicators of RDoC constructs (self-reports, behavior, and error-related brain activity) to explore their association with internalizing and externalizing dimensions of psychopathology. Participants (N = 182; 54% female) completed a questionnaire assessing clinical problems along with self-report scales and EEG tasks mapping the following RDoC constructs: Performance Monitoring (Cognitive Systems), Inhibitory Control (Cognitive Systems), and Sustained Threat (Negative Valence Systems). Unidimensional factors containing self-reported, behavioral, and neurophysiological data were successfully extracted for each of the RDoC constructs by using a psychoneurometric approach. Subsequently, we found that RDoC-based psychoneurometric constructs of Performance Monitoring and Inhibitory Control appeared to reflect distinctive processing deviations associated with the internalizing spectrum, possibly unveiling comorbidity mechanisms across internalizing conditions. In turn, the RDoC-based psychoneurometric factor of Sustained Threat exhibited associations with both internalizing and externalizing dimensions, possibly reflecting a mechanism of comorbidity at the p-factor level and increasing the vulnerability to develop any form of psychopathology. These findings provide a new approach toward a multimethod assessment linking neurobehavioral indicators with self-reported measures and highlight that concrete RDoC constructs relate to mental health outcomes.

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A dimensional approach to the neuronal correlates of anxiety, depression, and perfectionism: A transdiagnostic dissociation of error-related brain activity

Cited by 10 publications

References 68 publications

Modeling relations between event-related potential factors and broader versus narrower dimensions of externalizing psychopathology.

Modeling relations between event-related potential factors and broader versus narrower dimensions of externalizing psychopathology.

Explaining Brain-Behavior Relations: Inhibitory Control as an Intermediate Phenotype Between the N2 ERP and the Externalizing Spectrum in Childhood

Neurobehavioral Mechanisms of Comorbidity in Internalizing and Externalizing Psychopathology: An RDoC Multimethod Assessment

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