A Discovery-Based Friedel-Crafts Acylation Experiment: Student-Designed Experimental Procedure

Reeve, Anne McElwee

doi:10.1021/ed081p1497

Cited by 13 publications

(15 citation statements)

References 2 publications

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“…[56] Althought hese approaches are not uncommon in the general chemistry laboratory, [63,64] they have rarely been appliedi nt he organic laboratory. [65,66] This could be because organic protocols are more complex and their design requires greater student knowledge and experience.…”

Section: Organicchemistrymentioning

confidence: 99%

Green Chemistry in Higher Education: State of the Art, Challenges, and Future Trends

et al. 2018

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Nowadays, there is increasing interest in global sustainability, and thus, university students would like to know how human actions affect the health status of our planet. This is mainly due to their basic knowledge of problems such as global warming and greenhouse gases. Students would like to gain knowledge on how to safeguard the earth for future generations. This must involve changes in education programs at interested institutions and universities. To ensure that future generations of chemists are equipped with proper knowledge, significant efforts are needed. Thus, this article aims to present the history of green chemistry, its milestones, and ideas on how to teach this subject. A discussion of awareness in the field of green chemistry and of existing teaching materials is presented. In addition, green chemistry metrics, which should be known and used by professors and students, are described. Teaching methods for green chemistry are also given, with special attention paid to organic and analytical chemistry education.

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Section: Organicchemistrymentioning

confidence: 99%

Green Chemistry in Higher Education: State of the Art, Challenges, and Future Trends

et al. 2018

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“…Teaching acylation and nucleophilic substitution reactions is a fundamental concept in organic chemistry courses. − Nevertheless, N -formylation has not been published nor reported-up to our knowledge as an experiment in any chemistry laboratory course. In this paper, students prepared four different formamides using simple solvent-free procedures as a part of the introductory organic chemistry laboratory course.…”

Section: Introductionmentioning

confidence: 99%

Solvent-Free N-Formylation: An Experimental Application of Basic Concepts and Techniques of Organic Chemistry

et al. 2020

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N-Formamides are important intermediates in the synthesis of many pharmacologically active compounds and are used as protecting groups for amines or as catalysts in different reactions. The current Nformylation experiment is designed as a part of an introductory organic chemistry course for undergraduate students. The experiment includes formylation of substituted aromatic amines using formic acid under solventfree conditions. Students are introduced to laboratory safety precautions, reaction mechanism, and basic laboratory techniques such as a solvent-free reaction setup, reflux, filtration, melting point determination, yield calculation, and lab report write-up. Students synthesized four different formamides in 50−80% yield as a straightforward application of nucleophilic substitution reactions.

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“…The Friedel-Crafts acylation of an aromatic compound introduces an acyl group into the aromatic ring to form a new carbon-carbon bond [1] [2] [3]. The acylarenes produced by this reaction are important as reaction intermediates and can be converted into various derivatives.…”

Section: Introductionmentioning

confidence: 99%

Microwave Irradiation Effect on Intermolecular and Intramolecular Friedel-Crafts Acylation Reaction

Okada¹,

Fujitsu²

2020

GSC

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The effect of microwave irradiation on the intermolecular and intramolecular Friedel-Crafts acylation of aromatic compounds was investigated. Microwave irradiation had no effect on the intermolecular reaction but had an accelerating effect on the intramolecular reaction. This enhanced intramolecular reactivity that was attributed to the high probability of close proximity between the reaction sites.

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A Discovery-Based Friedel-Crafts Acylation Experiment: Student-Designed Experimental Procedure

Cited by 13 publications

References 2 publications

Green Chemistry in Higher Education: State of the Art, Challenges, and Future Trends

Green Chemistry in Higher Education: State of the Art, Challenges, and Future Trends

Solvent-Free N-Formylation: An Experimental Application of Basic Concepts and Techniques of Organic Chemistry

Microwave Irradiation Effect on Intermolecular and Intramolecular Friedel-Crafts Acylation Reaction

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