A disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and the risk of asthma: A meta-analysis

Liang, Siqiao; Wei, Xueqin; Chen, Gong; Wei, Jinmei; Chen, Zhangrong; Deng, Jingmin

doi:10.1016/j.humimm.2013.01.025

Cited by 38 publications

(37 citation statements)

References 34 publications

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“…All of these three ADAM33 SNPs were found to be associated with asthma in the dominant model. Notably, the association of rs2280089/T+1 with asthma was only observed in European and Latin American individuals (28). To the best of our knowledge, no previous study has demonstrated such an association in Asian individuals (28) and this is the first time that rs2280089/T+1 has been reported to be associated with asthma in an Asian population.…”

Section: Adam33 Polymorphisms and Association With Asthmamentioning

confidence: 66%

“…Thus, the aim of the present study was to evaluate the variations in the ADAM33 gene in the Li population. The present study focused on eight SNPs of the ADAM33 gene that have been reported to be significantly closely associated with asthma or airway hyperresponsiveness in several populations (28). Gene segments covering these eight ADAM33 gene SNPs were successfully amplified and the results indicated that three SNPs, rs44707/T2, rs2280089/T+1 and rs2787094/V4, were associated with asthma in a dominant model in a Li population.…”

Section: Discussionmentioning

confidence: 98%

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ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population

et al. 2017

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Abstract. A disintegrin and metalloprotease 33 (ADAM33)is an asthma susceptibility gene that has been proven to be present in certain human populations. The Li population is a minority ethnic group, most of whom maintain a distinctive lifestyle on Hainan Island in southern China. To the best of our knowledge, no previous study has established whether ADAM33 polymorphisms are associated with asthma in the Li population. Therefore, the ADAM33 polymorphisms in a Li population were investigated in the present study. A total of 150 asthma patients and 100 healthy subjects were enrolled in the present study, and their DNA samples were evaluated to analyze eight single-nucleotide polymorphisms (SNPs) on the ADAM33 gene. Asthma patients were subcategorized into low and high severity groups, and their SNP data were compared with the data of the control subjects. Single-marker and haplotype association was analyzed to demonstrate the association between ADAM33 SNPs and asthma using multiple genetic statistic tests. The results indicated significant differences in allele frequencies at the SNPs rs44707/T2 (P=0.008), rs2787094/V4 (P=0.028) and rs2280089/T+1 (P=0.021) between asthma patients and control subjects. The SNP rs44707/T2 was also found to be associated with the high severity group (P=0.024), although SNPs rs2787094/V4 were associated with the low severity group (P=0.019). Two haplotypes, GGAGAGT and GAAGGGT, were significantly associated with asthma (P=0.003 and 0.008, respectively). To the best of our knowledge, this is the first time that SNP rs2280089/T+1 has been reported to be associated with asthma in an Asian population. These data confirm that ADAM33 polymorphisms are associated with asthma susceptibility in the Li population and confirm the uniqueness of the Li minority population within China. IntroductionAsthma is a chronic inflammatory disease of the airway. More than 100 million people across the globe suffer from this disorder (Global strategy for asthma management and prevention; http://www.ginasthma.org). Airway inflammation, bronchial hyperresponsiveness (BHR), and reversible airflow obstruction are the primary characteristics of asthma. Among these, airway inflammation is most closely associated with the clinical symptoms. Currently, genetic and environmental factors have been found to be involved in the generation of asthma pathologies. Thus, the potential contribution of genetic factors is considered to be an interesting area of clinical and basic research.The A disintegrin and metalloprotease 33 (ADAM33) gene is an asthma susceptibility gene, which was first reported by Van Eerdewegh et al (1). The ADAM33 gene is mapped to the short arm of chromosome 20p13 in the human genome, and is predominantly expressed in airway smooth-muscle cells and lung fibroblast cells, but not in epithelial cells, T cells or inflammatory leukocytes (2-6). ADAM proteins are involved in cell-cell and cell-matrix interactions (5), cell migration (2,3), cell-cell adhesion and signal transduction (4). The following are c...

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Section: Adam33 Polymorphisms and Association With Asthmamentioning

confidence: 66%

Section: Discussionmentioning

confidence: 98%

ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population

et al. 2017

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“…Our meta-analysis results indicate that the ADAM33 V4 polymorphism is associated with an increased risk of asthma, suggesting that the V4 polymorphism may be a causative factor for the incidence of asthma. Although the exact function of ADAM33 in the development of asthma is not fully understood, a potential explanation is that ADAM33 is an important chemokine in the pathogenesis of asthma and gene mutations, and thus the expression level of ADAM33 is significantly correlated with susceptibility to asthma Liang et al, 2013). Because heterogeneity can be clearly observed, we performed stratified analyses based on the studies' source of controls and genotyping method.…”

Section: Quantitative Data Synthesismentioning

confidence: 99%

“…According to recent epidemiological studies, asthma is becoming one of the most prevalent diseases in developing countries, mainly occurring in children, females, and black persons (Liang et al, 2013). Approximately 300 million people are affected by asthma, causing nearly 180,000 deaths each year worldwide (Akinbami et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…ADAM33 is typically expressed in human lung fibroblasts and bronchial smooth muscle cells. Thus, alterations in ADAM33 activity may alter the function of these cells, leading to airway remodeling (Holgate et al, 2006;Liang et al, 2013). Importantly, bronchial hyper-reactivity and airway obstruction induced by the presence of airway remodeling is closely correlated with asthma (Lambrecht and Hammad, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Association between V4 polymorphism in the ADAM33 gene and asthma risk: a meta-analysis

Zheng

et al. 2015

Genet. Mol. Res.

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ABSTRACT. In this study, we evaluated the associations between the V4 (rs2787094 G>C) polymorphism in a disintegrin and metalloproteinase domain 33 (ADAM33) gene and asthma risk. We searched Web of Science, PubMed, Google Scholar, EBSCO, Cochrane Library, and CBM databases from inception through August 2013, without language restrictions. Meta-analysis was performed using the STATA 12.0 software. Crude odds ratios and 95% confidence intervals were calculated. Eight case-control studies were included, with a total of 2128 asthma patients and 3134 healthy controls. Our results suggest that the ADAM33 V4 polymorphism increases the risk of asthma. Subgroup analysis according to the source of controls revealed significant associations between the ADAM33 V4 polymorphism and risk of asthma in population-and hospital-based subgroups under allele and dominant models (all P < 0.05). Further subgroup analysis using the genotyping method suggested that the ADAM33 V4 polymorphism is correlated with asthma risk in the polymerase chain reaction-restriction fragment length polymorphism subgroup. However, no association was found in the non-polymerase chain reaction-restriction fragment length polymorphism subgroup. Meta-regression analyses showed that the genotyping method may be a main source of heterogeneity (P = 0.003). Our meta-analysis suggests that the ADAM33 V4 polymorphism contributes to the risk of asthma and may be utilized as a biomarker for the early diagnosis of asthma.

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T1 polymorphism in a disintegrin and metalloproteinase 33 (ADAM33) gene may contribute to the risk of childhood asthma in Asians

2017

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A disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and the risk of asthma: A meta-analysis

Cited by 38 publications

References 34 publications

ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population

ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population

Association between V4 polymorphism in the ADAM33 gene and asthma risk: a meta-analysis

T1 polymorphism in a disintegrin and metalloproteinase 33 (ADAM33) gene may contribute to the risk of childhood asthma in Asians

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