T1 polymorphism in a disintegrin and metalloproteinase 33 (ADAM33) gene may contribute to the risk of childhood asthma in Asians

Deng, Rui-Xue; Zhao, Fengyan; Zhong, Xiaoyun

doi:10.1007/s00011-017-1024-8

Cited by 11 publications

(11 citation statements)

References 44 publications

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“…In previous studies, the rs2280089, rs2280090, and rs2280091 SNP variants have shown significant as well as non-significant associations with asthma susceptibility 14. In the current case-control study, an analysis of these variants revealed that the minor allele and genotype frequencies showed no noticeable differences, indicating that the rs2280089, rs2280090, and rs2280091 markers may not be independently associated with asthma in the study population.…”

Section: Discussioncontrasting

confidence: 46%

“…The allele and genotype frequencies of these variants were also found to be non-significant after stratification based on age, gender, family history of asthma in asthmatics, and urban/rural/semi-urban population. Despite the reported significant associations of these SNPs with asthma in multiple populations, no significant association has been identified in sub-ethnic populations of the same origin 8,14,16,23. A recent study based on 2 cities of Pakistan (Islamabad and Lahore) reported a protective role of rs2280091 against asthma in a Pakistani population 24.…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies, the rs2280089, rs2280090, and rs2280091 SNP variants have shown significant as well as non-significant associations with asthma susceptibility in different asthmatic populations in Asia 14,15. Owing to the conflicting and variable results regarding the impact of these SNP variants of ADAM33 in manifestation of asthma,8,16 the current study was designed to determine the probable role of 3 SNP variants [rs2280089, rs2280090, and rs2280091] of ADAM33 in the pathogenesis of asthmatic complications in a local population of Northern and Central Punjab, Punjab, Pakistan.…”

mentioning

confidence: 90%

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Evaluation of ADAM33 gene’s single nucleotide polymorphism variants against asthma and the unique pattern of inheritance in Northern and Central Punjab, Pakistan

Ghani

Sabar

Bano

et al. 2019

SMJ

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Objectives: To investigate the relationship of 3 single nucleotide polymorphism (SNP) variants of ADAM33 with asthma susceptibility in patients from Northern and Central Punjab, Punjab, Pakistan. Methods: In this case-control study, healthy and asthmatic participants were recruited between 2015 and 2017. The SNPs of ADAM33 gene, rs2280089, rs2280090, and rs2280091 were analyzed in 296 asthma patients and 343 healthy controls, as well as linkage disequilibrium and haplotype analysis. Results: The non-significant differences were observed in allele and genotype frequencies of the SNPs in asthmatic and healthy persons even after population stratification based on age, caste, gender, family history, and environment. Although these SNPs were non-significant for disease susceptibility among children and adults, a fixed unique pattern of inheritance was nevertheless observed for the studied SNPs. Linkage disequilibrium analysis presented a very strong linkage between the SNP variants to predict their co-inheritance in study population. However, none of the haplotypes were found to be associated with asthma disease development. Conclusion: The studied SNPs of ADAM33 appeared to be non-significant for asthma susceptibility in Northern and Central Punjabi population. The fixed allele combination inheritance pattern was a unique observation contrary to findings in other global populations.

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Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 90%

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Evaluation of ADAM33 gene’s single nucleotide polymorphism variants against asthma and the unique pattern of inheritance in Northern and Central Punjab, Pakistan

Ghani

Sabar

Bano

et al. 2019

SMJ

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“…A meta-analysis performed by Li et al [ 73 ] showed that F+1, ST+4, and T2 polymorphisms were associated with pediatric asthma susceptibility, while S2 and V4 polymorphism were not associated with childhood asthma risk. Deng et al [ 74 ] found that T1 polymorphism was associated with asthma risk among Asian children. Therefore, ADAM33 gene could be proposed as childhood asthma susceptible gene.…”

Section: Discussionmentioning

confidence: 99%

Asthma susceptible genes in children

et al. 2020

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“…A meta-analysis performed by Li et al 63 showed that F + 1, ST + 4 and T2polymorphisms of ADAM33 gene were associated with pediatric asthma susceptibility and S2, V4 and polymorphisms were not associated with childhood asthma risk. Deng et al 64 found that T1 polymorphism was associated with asthma risks among Asian children. Therefore, ADAM33 gene could be proposed as childhood asthma susceptible gene.…”

Section: Sensitivity Analysis and Publication Biasmentioning

confidence: 99%

Asthma susceptible genes in children: A meta-analysis

Ruan

Shi

Zhang

et al. 2020

Preprint

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Background: During the last decade, a number of studies have evaluated the potential association between some genetic polymorphisms and childhood asthma risk, however, the results of published studies appeared conflicts. The aim of the present study was to investigate association between genetic polymorphisms and pediatric asthma. Methods: Relevant studies were searched in PubMed, Embase, Web of Science, CNKI (China National Knowledge Infrastructure), Wanfang and Weipu database. Pooled odds ratios (OR) with 95% confidence interval (CI) were calculated to access the strength of the associations. Results: 45 case-control studies were finally included in this meta-analysis. Eighteen SNPs were identified. Ten polymorphisms were found to be associated with asthma risk: IL-13 +2044G/A, IL-4 -590C/T, ADAM33 F+1, ADAM33 T2, ADAM33 T1, ADAM33 ST+4, ORMDL3 rs7216389, VDR ApaⅠ, VDR FokⅠ, VDR BsmⅠ. After subgroup analysis, IL-13 +2044G/A, ADAM33 T2, ADAM33 T1, VDR ApaⅠ, VDR BsmⅠ polymorphisms were associated with increased risk of asthma among Asian populations. IL-4 -590C/T polymorphisms may be related to asthma risk in Chinese children.Conclusions: This meta-analysis found that IL-13 +2044G/A, IL-4 -590C/T, ADAM33 F+1, ADAM33 T2, ADAM33 T1, ADAM33 ST+4, ORMDL3 rs7216389, VDR ApaⅠ, VDR FokⅠ and VDR BsmⅠ polymorphisms might be risk factors for childhood asthma. Further study with large population and more ethnicities is needed to estimate the associations.

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T1 polymorphism in a disintegrin and metalloproteinase 33 (ADAM33) gene may contribute to the risk of childhood asthma in Asians

Abstract: These findings demonstrate that ADAM33 T1 polymorphism might be a potential susceptible predictor of asthma for Asian children. Further functional studies between this polymorphism and asthma risks are warranted.

Cited by 11 publications

References 44 publications

Evaluation of ADAM33 gene’s single nucleotide polymorphism variants against asthma and the unique pattern of inheritance in Northern and Central Punjab, Pakistan

Evaluation of ADAM33 gene’s single nucleotide polymorphism variants against asthma and the unique pattern of inheritance in Northern and Central Punjab, Pakistan

Asthma susceptible genes in children

Asthma susceptible genes in children: A meta-analysis

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