A disorder of sympathomimetic amines leading to increased vascular permeability may be the etiologic factor in various treatment refractory health problems in women

Is There An Association Between Chronic Urticaria and Fibromyalgia Syndrome?

“…22,23 In addition, it is hypothesized that patients with CU have an inappropriate sympathetic nervous system response to the increase in hydrostatic pressure while standing. 23 Furthermore, some authors have suggested that there is a reduced capability to enhance the sympathetic activity in vessels due to the autonomic dysfunction in patients with FM. 20,21 The pathogenesis of CU and FM is still unknown, 17,37 but it is difficult to claim that CU and FM originate from the same etiopathogenesis.…”

“…[15][16][17][18][19] In addition, it has been suggested that there is an autonomic dysfunction in patients with FM and CU, and sympathomimetic amines may lead to improvement in the symptoms of the two diseases when there is a resistance to conventional therapies. [20][21][22][23] Taking into account all of this information, we investigated whether patients with CU are also affected by FM.…”

Novel Highly Effective Medical Treatment of Severe Treatment Refractory Crohnʼs Disease Using Sympathomimetic Amines: Case Report

“…1 Although these chronic debilitating health conditions respond quickly and very effectively to low doses of sympathomimetic amines (especially dextroamphetamine sulfate), most treating physicians are unaware of this condition. Thus, many women go through an array of painful and expensive tests and receive various treatments with minimal effectiveness and frequently many side effects when they could find great relief from a small dose (10-30 mg) of sustained release dextroamphetamine sulfate.…”

“…Thus, many women go through an array of painful and expensive tests and receive various treatments with minimal effectiveness and frequently many side effects when they could find great relief from a small dose (10-30 mg) of sustained release dextroamphetamine sulfate. 1 These chronic disorders refractory to ''standard treatment'' may manifest as pain disorders, e.g., pelvic pain, abdominal pain, interstitial cystitis, backache, headache, arthritis, fibromyalgia, and mastalgia. 1 This disorder of the sympathetic nervous system may also manifest as unexplained weight gain, urticaria, chronic fatigue, and vasomotor symptoms unresponsive to estrogen, and a pseudohypothyroid state.…”

“…1 These chronic disorders refractory to ''standard treatment'' may manifest as pain disorders, e.g., pelvic pain, abdominal pain, interstitial cystitis, backache, headache, arthritis, fibromyalgia, and mastalgia. 1 This disorder of the sympathetic nervous system may also manifest as unexplained weight gain, urticaria, chronic fatigue, and vasomotor symptoms unresponsive to estrogen, and a pseudohypothyroid state. 1 This condition has been recently named the sympathetic neural hyperalgesia edema syndrome.…”