A disparate 3-D silver(I) coordination polymer of pyridine-3,5-dicarboxylate and pyrimidine with strong intermetallic interactions: X-ray crystallography, photoluminescence and antimicrobial activity

Alisir, Sevim Hamamci; Demir, Serkan; Sarıboğa, Bahtiyar; Büyükgüngör, Orhan

doi:10.1080/00958972.2014.978307

Cited by 32 publications

(12 citation statements)

References 40 publications

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“…Moreover, at MIC doses, [Ag(NO 3 )(4,7-phen)] n and [Ag(CF 3 COO)(4,7-phen)] n (4,7-phen is 4,7-phenanthroline) totally prevented C. albicans filamentation and rescued the infected zebrafish of the lethal infection outcome [21]. Similarly, silver(I) complexes with substituted imidazoles, 2amino-3-methylpyridine, pyridine-2-carboxaldoxime, and pyridine-3,5-dicarboxylate showed considerable anti-Candida activity and only moderate effectiveness against the tested bacterial strains [40][41][42]. On the other hand, a selective antibacterial activity, especially against P. aeruginosa, was observed for silver(I) complexes with N-heterocycles containing two nitrogen atoms within one ring, such as diazines (pyridazine, pyrimidine, and pyrazine), benzodiazines (phthalazine, quinazoline, and quinoxaline), and phenazine [18][19][20].…”

Section: Biological Evaluation Of Silver(i) Complexes 1-3mentioning

confidence: 98%

Antimicrobial Activity and DNA/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane/ethene as Bridging Ligands

Đurić

Vojnović

Andrejević

et al. 2020

Bioinorganic Chemistry and Applications

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1,2-Bis(4-pyridyl)ethane (bpa) and 1,2-bis(4-pyridyl)ethene (bpe) were used for the synthesis of polynuclear silver(I) complexes, {[Ag(bpa)]NO 3 } n (1), {[Ag(bpa) 2 ]CF 3 SO 3 . H 2 O} n (2) and {[Ag(bpe)]CF 3 SO 3 } n (3). In complexes 1-3, the corresponding nitrogencontaining heterocycle acts as a bridging ligand between two Ag(I) ions. In vitro antimicrobial activity of these complexes, along with the ligands used for their synthesis, was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and fungi. e silver(I) complexes 1-3 showed selectivity towards Candida spp. and Gram-negative Escherichia coli in comparison to the other investigated bacterial strains, effectively inhibiting the growth of four different Candida species with minimal inhibitory concentrations (MICs) between 2.5 and 25 μg/mL and the growth of E. coli, with MIC value being 12.5 μg/mL. Importantly, complex 2 significantly reduced C. albicans filamentation, an essential process for its pathogenesis. Antiproliferative effect on the normal human lung fibroblast cell line MRC-5 was also evaluated with the aim of determining the therapeutic potential of the complexes 1-3. e interactions of these complexes with calf thymus DNA (ctDNA) and bovine serum albumin (BSA) were studied to evaluate their binding activities towards these biomolecules for possible insights on their mode of action.

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Section: Biological Evaluation Of Silver(i) Complexes 1-3mentioning

confidence: 98%

Antimicrobial Activity and DNA/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane/ethene as Bridging Ligands

Đurić

Vojnović

Andrejević

et al. 2020

Bioinorganic Chemistry and Applications

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“…Over the past decades, research into Ag (I) complexes and coordination polymers (CPs) is rapidly progressing due to their wide structural diversity and functional properties such as intriguing photoluminescence, [1][2][3][4][5][6][7][8] catalytic [9][10][11] and antimicrobial activities. [6,[12][13][14][15] The versatile coordination behavior of Ag (I) ion allows to design a wide range of assemblies ranging from molecular complexes to chain and layered polymers as well as 3D metal-organic frameworks. [16][17][18] Noteworthy, the functional properties of these compounds are often influenced by weak non-covalent interactions of Ag•••Ag, Ag•••π and Ag•••X type, [19,20] playing an important role along with dominating effect of the ligand environment.…”

Section: Introductionmentioning

confidence: 99%

0D to 3D Coordination Assemblies Engineered on Silver(I) Salts and 2‐(Alkylsulfanyl)azine Ligands: Crystal Structures, Dual Luminescence, and Cytotoxic Activity

et al. 2020

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The potential of 2‐(alkylsulfanyl)azine ligands for crystal engineering of functional Ag(I) complexes has been firstly demonstrated. The reaction of AgNO3, AgClO4 and AgOTf with 2‐(alkylsulfanyl)pyridines, ‐pyrimidines, and ‐quinolines gives a series of new Ag(I) compounds that range from mono‐ and dinuclear complexes to chain (1D), layered (2D) and framework (3D) coordination polymers (CPs). 2‐(Alkylsulfanyl)pyridines and ‐pyrimidines, depending on the reaction conditions, are assembled either into molecular complexes or CPs, while 2‐(alkylsulfanyl)quinolines afford dinuclear complexes exclusively. The most of compounds engineered feature site‐specific interactions such as Ag···Ag, Ag···O, and Ag···S ones. The 2‐(methylsulfanyl)quinoline (2‐MeSQn) complex, [Ag2(2‐MeSQn)2(NO3)2], displays room temperature intraligand (IL) phosphorescence, while the 2‐(methylsulfanyl)pyridine‐derived CPs emit dual luminescence expressed by IL fluorescence and phosphorescence. Moreover, cytotoxic activity of the compounds synthesized has been evaluated against hTERT lung fibroblasts, HeLa, MCF7, HepG2 and A549 cancer cells.

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“…Silver compounds are also well known for their antimicrobial properties and are widely used in the treatment of wounds and burn infections [7,8,9,10]. The combination of benzimidazole or pyridine derivatives with silver ions leads the production of compounds with novel biological properties which can be an attractive alternative to existing treatments [11,12,13,14,15].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3

et al. 2016

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Selected aspects of the biological activity of a series of six nitrate silver(I) complexes with pyridine and (benz)imidazole derivatives were investigated. The present study evaluated the antibacterial activities of the complexes against three Gram-negative strains: Pseudomonas aeruginosa ATCC 15442, Escherichia coli ATCC 25922 and Proteus hauseri ATCC 13315. The results were compared with those of silver nitrate, a silver sulfadiazine drug and appropriate ligands. The most significant antibacterial properties were exerted by silver(I) complexes containing benzimidazole derivatives. The cytotoxic activity of the complexes was examined against B16 (murine melanoma) and 10T1/2 (murine fibroblasts) cells. All of the tested silver(I) compounds were not toxic to fibroblast cells in concentration inhibited cancer cell (B16) viability by 50%, which ranged between 2.44-28.65 µM. The molecular and crystal structure of silver(I) complex of 2,6-di(hydroxymethyl)pyridine was determined by single-crystal X-ray diffraction analysis. The most important features of the crystal packing and intermolecular non-covalent interactions in the Ag(I) complex were quantified via Hirshfeld surface analysis.

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A disparate 3-D silver(I) coordination polymer of pyridine-3,5-dicarboxylate and pyrimidine with strong intermetallic interactions: X-ray crystallography, photoluminescence and antimicrobial activity

Cited by 32 publications

References 40 publications

Antimicrobial Activity and DNA/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane/ethene as Bridging Ligands

Antimicrobial Activity and DNA/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane/ethene as Bridging Ligands

0D to 3D Coordination Assemblies Engineered on Silver(I) Salts and 2‐(Alkylsulfanyl)azine Ligands: Crystal Structures, Dual Luminescence, and Cytotoxic Activity

Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3

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