A disposable microfluidic flow sensor with a reusable sensing substrate

Kim, Jin-Ho; Cho, Hyungseok; Han, Song‐I; Han, Arum; Han, Ki-Ho

doi:10.1016/j.snb.2019.02.088

Cited by 19 publications

(15 citation statements)

References 38 publications

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“…Because the droplet detection method is based on a capacitive, impedimetric measurement that uses the dielectric constant difference between the continuous and dispersed phases, the sensitivity does not change significantly when the dispersed phase is replaced with other aqueous solutions. 34 Our previous study 33 showed that the detectable flow rate of the on-chip integrated flow sensor can be enhanced by two Fig. 6 Long-term drift in the length of droplets generated for 60 min using two pressure pumps with the proposed feedback control, two pressure pumps without feedback control, and a syringe pump and a pressure pump without feedback control.…”

Section: Discussionmentioning

confidence: 99%

“…To solve this problem, the flow sensor should be disposable; however, this is practically impossible owing to the high price of commercialized microfluidic flow sensors. 33 In this paper, we present a real-time feedback control using a disposable film-chip microfluidic device that can simultaneously control the droplet size and production rate with an on-chip integrated droplet detector and flow sensor. In a previous study, 34 we introduced a disposable capacitive droplet detection method (DisC-EDM) for realtime droplet detection, consisting of a reusable sensing substrate and a disposable microchannel, constructed using a simple and inexpensive film-chip fabrication process.…”

Section: Introductionmentioning

confidence: 99%

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dDrop-Chip: disposable film-chip microfluidic device for real-time droplet feedback control

2023

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

dDrop-Chip: disposable film-chip microfluidic device for real-time droplet feedback control

2023

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“…The reusable substrate supports the disposable superstrate during vacuum assembly and prevents the PET film from warping and twisting. In addition, to implement various microfluidic functions along with the lateral degassing method, the reusable substrate can be made capable of generating energy fields that can be transmitted through the PET film and can actively manipulate and detect the substances in the microchannel [ 41 , 42 , 43 ]. The disposable superstrate and the reusable substrate are tightly assembled by vacuum pressure exerted through the vacuum hole.…”

Section: Methodsmentioning

confidence: 99%

Lateral Degassing Method for Disposable Film-Chip Microfluidic Devices

et al. 2021

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It is critical to develop a fast and simple method to remove air bubbles inside microchannels for automated, reliable, and reproducible microfluidic devices. As an active degassing method, this study introduces a lateral degassing method that can be easily implemented in disposable film-chip microfluidic devices. This method uses a disposable film-chip microchannel superstrate and a reusable substrate, which can be assembled and disassembled simply by vacuum pressure. The disposable microchannel superstrate is readily fabricated by bonding a microstructured polydimethylsiloxane replica and a silicone-coated release polymeric thin film. The reusable substrate can be a plate that has no function or is equipped with the ability to actively manipulate and sense substances in the microchannel by an elaborately patterned energy field. The degassing rate of the lateral degassing method and the maximum available pressure in the microchannel equipped with lateral degassing were evaluated. The usefulness of this method was demonstrated using complex structured microfluidic devices, such as a meandering microchannel, a microvortex, a gradient micromixer, and a herringbone micromixer, which often suffer from bubble formation. In conclusion, as an easy-to-implement and easy-to-use technique, the lateral degassing method will be a key technique to address the bubble formation problem of microfluidic devices.

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“…Heating small areas with microheaters is an important task for several applications, from flow-sensing [ 37 , 38 ], degassing, driving and assisting electrochemical sensors [ 39 , 40 , 41 , 42 , 43 , 44 ], to microfluidic system temperature control and sensing [ 45 , 46 , 47 ]. Carbon and graphene-based printed devices have recently demonstrated unprecedented performance in temperature sensing and microheater fabrication [ 16 , 48 , 49 , 50 , 51 ]; due to their unique properties, such as high mechanical durability, resistance to environmental corrosion and contamination, and an ability to reach high temperatures without changing their properties, these materials are excellent candidates for these applications.…”

Section: Introductionmentioning

confidence: 99%

Study of Single and Multipass f–rGO Inkjet-Printed Structures with Various Concentrations: Electrical and Thermal Evaluation

Apostolakis

Barmpakos

Pilatis

et al. 2023

Sensors

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Reduced graphene oxide (rGO) is a derivative of graphene, which has been widely used as the conductive pigment of many water-based inks and is recognized as one of the most promising graphene-based materials for large-scale and low-cost production processes. In this work, we evaluate a custom functionalised reduced graphene oxide ink (f–rGO) via inkjet-printing technology. Test line structures were designed and fabricated by the inkjet printing process using the f–rGO ink on a pretreated polyimide substrate. For the electrical characterisation of these devices, two-point (2P) and four-point (4P) probe measurements were implemented. The results showed a major effect of the number of printed passes on the resulting resistance for all ink concentrations in both 2P and 4P cases. Interesting results can be extracted by comparing the obtained multipass resistance values that results to similar effective concentration with less passes. These measurements can provide the ground to grasp the variation in resistance values due to the different ink concentrations, and printing passes and can provide a useful guide in achieving specific resistance values with adequate precision. Accompanying topography measurements have been conducted with white-light interferometry. Furthermore, thermal characterisation was carried out to evaluate the operation of the devices as temperature sensors and heaters. It has been found that ink concentration and printing passes directly influence the performance of both the temperature sensors and heaters.

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A disposable microfluidic flow sensor with a reusable sensing substrate

Cited by 19 publications

References 38 publications

dDrop-Chip: disposable film-chip microfluidic device for real-time droplet feedback control

dDrop-Chip: disposable film-chip microfluidic device for real-time droplet feedback control

Lateral Degassing Method for Disposable Film-Chip Microfluidic Devices

Study of Single and Multipass f–rGO Inkjet-Printed Structures with Various Concentrations: Electrical and Thermal Evaluation

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