A distinct serum metabolic signature of distant metastatic papillary thyroid carcinoma

Abstract

Serum metabolomics profiling could significantly discriminate papillary thyroid cancer patients according to distant metastasis. Potential metabolic aberration in distant metastatic PTC could be involved in different biological behaviours of tumour cells including proliferation, invasion/migration and immune escape. Diet/gut microbiota-produced metabolites could play an important role in these effects. This work may provide new clues to find the underlying mechanisms regarding the distant metastasis of PTC as well as potential adjuvant therapy targets.

Alterations in the gut microbiota and metabolite profiles of thyroid carcinoma patients

“…59 Notably, the thyroid function of all enrolled TC patients was normal in our study, and previous metabonomic studies have increasingly shown that dysbiosis of lipid metabolism is observed in different samples from TC patients, such as serum, plasma, tissue and urine. [29][30][31]33 Thus, we further considered fecal lipid metabolism dysregulation, one of the crucial factors in TC pathogenesis.…”

“…29,34 Significant changes in serum linolenic acid, phospholipids and gammaaminobutyric acid were observed in TC patients. 30,31 Phenol and 4-hydroxybutanoic acid levels were changed in the exhaled breath of TC patients. 32 Among these metabolites, gammaaminobutyric acid and phenol participate in the oncogenesis/ metastasis of various carcinomas, and some metabolites may be potential signatures for TC diagnosis.…”

“…In contrast, extensive metabolomics studies have used different samples from TC patients, including thyroid tissue, serum, exhaled breath and urine . Changes in the concentrations of lipids (linolenic acid and sphingomyelin), galactinol and inosine were identified by TC tissue metabolic profiling .…”

“…Changes in the concentrations of lipids (linolenic acid and sphingomyelin), galactinol and inosine were identified by TC tissue metabolic profiling . Significant changes in serum linolenic acid, phospholipids and gamma‐aminobutyric acid were observed in TC patients . Phenol and 4‐hydroxybutanoic acid levels were changed in the exhaled breath of TC patients .…”

“…23,24,28 In contrast, extensive metabolomics studies have used different samples from TC patients, including thyroid tissue, serum, exhaled breath and urine. [29][30][31][32][33][34] Changes in the concentrations of lipids (linolenic acid and sphingomyelin), galactinol and inosine were identified by TC tissue metabolic profiling. 29,34 Significant changes in serum linolenic acid, phospholipids and gammaaminobutyric acid were observed in TC patients.…”