A dithiacyclam-coordinated silver(i) polymer with anti-cancer stem cell activity

Abstract

A cancer stem cell (CSC) active, solution stable, silver(I) polymeric complex bearing a dithiacyclam ligand is reported. The complex displays similar potency towards CSCs as salinomycin in monolayer and three-dimensional...

Silver Complexes as Anticancer Agents: A Perspective Review

“…The dithiacylam-Ag (I) complex 48 reacted with the GSH redox buffering system of the cell lines HMLER or HMLER-shEcad, thereby inducing ROS intracellularly elevation caspase-dependent cell apoptosis [54]. The cytotoxic activity of Ag (I)-dipeptide complex against MCF-7, MDA-MB-231, HCT 116, BLM and Jurkat cancer cells and BJ-5ta (non-cancer) cells were evaluated using an MTS assay.…”

Synthesis and Characterization of Phosphorus-Containing Isocyclam Macrocycles and Their Nickel Complexes

“…Due to their drug-like properties, their good solubility, lipophilicity, metabolic stability, and bioavailability, sophisticated macrocycles were shown to possess high therapeutic potential. ,, Along this line, multidentate macrocycles are predominantly used as chelating ligands in transition metal complexes, which in turn find main application in the fields of biomedical imaging, biomimetics, and catalysis. , Here, in particular, tetradentate N-macrocyclic systems, with the 14-membered ring cyclam 1 (=1,4,8,11-tetraazacyclotetradecane) as one of the most common representatives, proved to be versatile applicable (Figure ). − While the nickel complex [Ni­(cyclam)] 2+ 2 with the tetraaza ligand 1 is known as an efficient and selective electrocatalyst for the reduction of CO 2 to CO, the iron complex [Fe­(TMC)] 2+ 3 (TMC = 1,4,8,11-tetramethylcyclam) comprising a fully methylated version of the macrocycle 1 is known for the activation of O 2 (Figure ). , In these systems, the macrocyclic ligand is the crucial component as it stabilizes the unusual intermediate Ni I and Fe IV oxidation states. − …”

Coordination complexes of zinc and manganese based on pyridine-2,5-dicarboxylic acid N-oxide: DFT studies and antiproliferative activities consideration

“…They can be classified into two groups; (i) those containing the classical noble metals such as Pt, Ru, Au, Ti, and Pd which are the most promising candidates in the treatment of several tumors and (ii) those of low-cost, bio-essential metals such as Cu, Fe, Zn and Mn. 1–8 The former group suffers from some clinical problems such as toxicity, solubility and drug half-life while the latter group are better dealt by human physiology and cause less damaging side effects. Despite the variety of physiological roles of the zinc and manganese ions and their complexes, they have been less studied as metal-based anticancer drugs.…”