A DNA biosensor based on the detection of doxorubicin-conjugated Ag nanoparticle labels using solid-state voltammetry

Ting, Boon Ping; Zhang, Jie; Gao, Zhiqiang; Ying, Jackie Y.

doi:10.1016/j.bios.2009.07.005

Cited by 79 publications

(38 citation statements)

References 43 publications

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“…As an alternative, biosensors have been studied for the detection of AI H5N1 virus (Kukol et al, 2008;Pavlovic et al, 2008;Deng et al, 2009;Ho et al, 2009;Tam et al, 2009;Ting et al, 2009;Wang et al, 2009) for rapid and reliable testing of influenza with minimal sample handling and laboratory skill requirements (Amano and Cheng, 2005). Microgravimetric quartz crystal microbalance (QCM), owing to its simplicity and cost effectiveness, has been extensively investigated as a transducer for virus detection such as influenza A and B viruses (Owen et al, 2007;Hewa et al, 2009), dengue virus Chen et al, 2009a), airborne vaccinia viruses (Lee et al, 2008), flavivirus (Tai et al, 2006), bovine ephemeral fever virus , hybridization of hepatitis B virus (Yao et al, 2008), human rhinovirus (HRV) and the foot-and-mouth disease virus (FMDV) (Tai et al, ,2006Jenik et al, 2009), and other viruses (Abad et al, 1998;Eun et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

A nanobeads amplified QCM immunosensor for the detection of avian influenza virus H5N1

Wang

et al. 2011

Biosensors and Bioelectronics

127

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Section: Introductionmentioning

confidence: 99%

A nanobeads amplified QCM immunosensor for the detection of avian influenza virus H5N1

Wang

et al. 2011

Biosensors and Bioelectronics

127

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“…DNA sensors based on indirect methods require the use of labels or electroactive indicators, such as ferrocenyl derivatives (Nakayama, 2002), redox-active enzymes (Patolsky et al, 2001), nanoparticles (Ting et al, 2009), and redox intercalators (Ferapontova and Gothelf, 2009;Millan and Mikkelsen, 1993). Strategies involving labels are time-and labor-consuming and they do not allow real-time detection of target-probe coupling.…”

Section: Introductionmentioning

confidence: 99%

Label-free electrochemical DNA sensor using “click”-functionalized PEDOT electrodes

Galán

Prieto‐Simón

Alvira

et al. 2015

Biosensors and Bioelectronics

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Here we describe a label-free electrochemical DNA sensor based on poly(3,4-ethylenedioxythiophene)-modified (PEDOT-modified) electrodes. An acetylene-terminated DNA probe, complementary to a specific "Hepatitis C" virus sequence, was immobilized onto azido-derivatized conducting PEDOT electrodes using "click" chemistry. DNA hybridization was then detected by differential pulse voltammetry, evaluating the changes in the electrochemical properties of the polymer produced by the recognition event. A limit of detection of 0.13 nM was achieved using this highly selective PEDOT-based genosensor, without the need for labeling techniques or microelectrode fabrication processes. These results are promising for the development of label-free and reagentless DNA hybridization sensors based on conducting polymeric substrates. Biosensors can be easily prepared using any DNA sequence containing an alkyne moiety. The data presented here reveal the potential of this DNA sensor for diagnostic applications in the screening of diseases, such as "Hepatitis C", and genetic mutations.

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“…When the size of these nanoparticles becomes so small that their dimension can be considered as a single domain, they lack a hysteresis loop and a possess high field irreversibility, high saturation field and extra anisotropy contributions i.e., SPION [2] [3]. Since, magnetic nanoparticles (MNPs) obey the Coulomb's law and are easily controlled by an external magnetic field, thus they can be utilized for various industrial and biomedical applications such as photonic devices [4] [5], hyperthermia [6] [7] targeted drug delivery [8] [9] bioimaging [10] [11] and biomolecular sensing [12] [13].…”

Section: Introductionmentioning

confidence: 99%

Dynamics Study and Analysis of Laser-Induced Transport of Nanoferrofluid in Water Using Fluorescein Isothiocyanate (FITC) as Fluorescence Marker

Khosroshahi¹,

Asemani²

2017

JMP

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FITC-conjugated nanoferrofluid (FNFF) was synthesized and characterized to study the dynamic of laser-induced transport of NPs in water. The results confirmed a definite laser-induced enhanced velocity of NPs (100 μm·s without and with laser action respectively. The act of laser when switched on after NPs had reached the steady state was very prominent. The laser-induced heat and power generated by NPs were calculated 0.2 μW·cm −3 and 0.4 pW·cm −2 respectively. Our experiment condition was non-adiabatic and that the heat generated was diffused into the surrounding. We considered the Maxwell's criteria (Kp/Kw < 10) for FNFF thermal conductivity and found a value of 1.2 Wm. Based on the Brownian diffusion and DLVO theory, at earlier times where the NPs are more dispersed within the medium are displaced faster. However, at later stages they become less mobile as they are agglomerated. The mechanisms for the enhanced mobility and laser transport of NPs are thought to be due to e.m.w induced force (i.e. an oscillatory motion) and laser absorptive force (i.e., photothermophoresis). A beam divergence of about 5.24˚ (or 91 mrad) was determined. A non-linear behaviour of laser beam was observed as a trajectory path within the water due to thermal heating hence causing the change of refractive index of medium and redistribution of NPs concentration.

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A DNA biosensor based on the detection of doxorubicin-conjugated Ag nanoparticle labels using solid-state voltammetry

Cited by 79 publications

References 43 publications

A nanobeads amplified QCM immunosensor for the detection of avian influenza virus H5N1

A nanobeads amplified QCM immunosensor for the detection of avian influenza virus H5N1

Label-free electrochemical DNA sensor using “click”-functionalized PEDOT electrodes

Dynamics Study and Analysis of Laser-Induced Transport of Nanoferrofluid in Water Using Fluorescein Isothiocyanate (FITC) as Fluorescence Marker

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