A dominant strain of Elizabethkingia anophelis emerged from a hospital water system to cause a three-year outbreak in a respiratory care center

Lee, Yu-Lin; Km, Liu; Hl, Chang; Lin, Jian‐Sheng; Fy, Kung; Cm, Ho; Kh, Lin; Chen, Ying-Tsong

doi:10.1016/j.jhin.2020.10.025

Cited by 22 publications

(27 citation statements)

References 39 publications

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“…The first intrahospital outbreak was detected in 2015 in a respiratory care center with 4 patients involved. A dominant lineage of E. anophelis strains had been identified according to PFGE analysis during the early outbreak investigations ( 20 ). Intensive infection control strategies were implemented since 2016 and the case number had been reduced gradually.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-two E. anophelis strains included in previous PFGE studies were selected for complete genomic sequencing and comparative genomic analysis ( 20 ). The isolates, including 18 strains belonging to the specific lineage and 4 other E. anophelis strains were selected based on their pulsotypes.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, we reported a 3-year outbreak of E. anophelis infection at a tertiary hospital in central Taiwan ( 20 ). A dominant lineage of E. anophelis strains was identified by pulsed-field gel electrophoresis (PFGE) analysis.…”

Section: Introductionmentioning

confidence: 99%

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The Evolutionary Trend and Genomic Features of an Emerging Lineage of Elizabethkingia anophelis Strains in Taiwan

et al. 2022

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Elizabethkingia anophelis is an emerging multidrug resistant pathogen caused several global outbreaks recently. E. anophelis was frequently misidentified as E. meningoseptica in the past by conventional culture methods; therefore, the prevalence was often underestimated. Through revised identification, an increasing trend of E. anophelis infection was noted in a tertiary hospital and a dominant lineage of strains was recognized by genotyping.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The Evolutionary Trend and Genomic Features of an Emerging Lineage of Elizabethkingia anophelis Strains in Taiwan

et al. 2022

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“…Because of the association between E. anophelis and mosquitoes, it was initially posited that mosquitoes may be a vector ( Frank et al, 2013 ). Subsequent studies suggest that E. anophelis cases are far more likely to be hospital acquired infections, although sporadic, community-acquired cases have been reported ( Hayek et al, 2013 ; Perrin et al, 2017 ; Lee et al, 2021 ). One characteristic that makes E. anophelis infections particularly challenging in the clinical environment is that the bacterium is resistant to multiple antibiotics including cephalosporins, aminoglycosides, and carbapenems ( González and Vila, 2012 ; Breurec et al, 2016 ).…”

Section: A Path Forward: a Most Wanted List For Microbes In Gnotobiotic Studiesmentioning

confidence: 99%

The Axenic and Gnotobiotic Mosquito: Emerging Models for Microbiome Host Interactions

et al. 2021

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The increasing availability of modern research tools has enabled a revolution in studies of non-model organisms. Yet, one aspect that remains difficult or impossible to control in many model and most non-model organisms is the presence and composition of the host-associated microbiota or the microbiome. In this review, we explore the development of axenic (microbe-free) mosquito models and what these systems reveal about the role of the microbiome in mosquito biology. Additionally, the axenic host is a blank template on which a microbiome of known composition can be introduced, also known as a gnotobiotic organism. Finally, we identify a “most wanted” list of common mosquito microbiome members that show the greatest potential to influence host phenotypes. We propose that these are high-value targets to be employed in future gnotobiotic studies. The use of axenic and gnotobiotic organisms will transition the microbiome into another experimental variable that can be manipulated and controlled. Through these efforts, the mosquito will be a true model for examining host microbiome interactions.

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“…Studies involving a three years long outbreak spanning a time period from 2015 to 2018 in Taiwan resulted in the identification of a specific E. Anophelis strain. Transmission mechanism patterns in 26 patients were studied using Pulsed-field gel electrophoresis (PFGE) and completegenome sequencing [14].…”

Section: Introductionmentioning

confidence: 99%

Emerging outbreak of Elizabethkingia anopheles: a systematic review of the literature

Wahid

Rani

2021

BioSci Rev.

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The recent outbreak of Elizabethkingia anopheles in Midwest countries has caused a number of deaths. Notably Elizabethkingia anopheles causes neonatal meningitis, bacteraemia, sepsis, blood stream infections and respiratory infections. This infection may pose serious threats to public health because of lack of sufficient research and its endemic potential unknown. This systematic review was meant to develop a deeper insight into the current status of E. anophelis related evidence and to highlight areas that need further research. Reviewing existing literature will help other researchers in identifying and addressing the knowledge gaps. Various free access databases such as Google Scholar, Scopus, PubMed, and Science Direct were employed for literature survey. All articles that have been published since 2011, when the outbreak was reported for the first time have been included in this systematic review. The research related to this subject is in earlier stages and little information is currently available. Future studies must focus on the molecular basis, control, prevention, and therapeutics of E. anophelis infection to mitigate its increasing risk. This review is meant to provide baseline data for future research. Scientific community must carry out research on infections caused by E. anophelis mosquito else it will result in a disastrous outbreak.

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A dominant strain of Elizabethkingia anophelis emerged from a hospital water system to cause a three-year outbreak in a respiratory care center

Cited by 22 publications

References 39 publications

The Evolutionary Trend and Genomic Features of an Emerging Lineage of Elizabethkingia anophelis Strains in Taiwan

The Evolutionary Trend and Genomic Features of an Emerging Lineage of Elizabethkingia anophelis Strains in Taiwan

The Axenic and Gnotobiotic Mosquito: Emerging Models for Microbiome Host Interactions

Emerging outbreak of Elizabethkingia anopheles: a systematic review of the literature

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