A donor–acceptor type macrocycle: toward photolyzable self-assembly

Tian, Tian; Qian, Tingjuan; Jiang, Tingting; Deng, Yakui; Li, Xiaopei; Yuan, Wei; Chen, Yulan; Wang, Yixuan; Hu, Wenping

doi:10.1039/d0cc01350a

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…The combined extracts were first washed with 10% Na 2 S 2 O 3 , then with brine, and dried over Na 2 SO 4 . The crude residue was purified by column chromatography over silica gel (eluent: CHCl 3 /MeOH = 100/1) to afford the desired iodide derivative S5 (178 mg, 90%) as a colorless liquid …”

Section: Methodsmentioning

confidence: 99%

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Synthesis and Biological Evaluation of a c(RGDyK) Peptide Conjugate of SRPIN803

et al. 2021

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In the present study, SRPIN803 and c(RGDyK)-SRPIN803 hybrid compounds were efficiently synthesized and evaluated for their stability in human plasma and buffers of pH 7.4 and 5.2. The hybrids were mainly cytostatic against a panel of tested cancer cells, whereas one c(RGDyK)-SRPIN803 hybrid, geo35, was the most active compound in this screen and was cytotoxic against cell lines MCF7 and MRC5 with IC 50 values of 61 and 63 μM, respectively. SRPIN803 and geo35 exhibited antiangiogenic activity in zebrafish embryos, and this effect was dose-dependent. Although c(RGDyK)-SRPIN803 hybrid compounds were found less potent compared to SRPIN803, they have shown activities interesting enough to illustrate the potential of this approach for the development of a new class of antiangiogenic compounds.

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Section: Methodsmentioning

confidence: 99%

“…29 S5: 1 H NMR (500 MHz, CDCl 3 ) δ 3.79−3.75 (m, 2H), 3.74 (d, J = 5.6 Hz, 2H), 3.71−3.66 (m, 4H), 3.65−3.61 (m, 2H), 3.27 (t, J = 6.8 Hz, 2H), 2.17 (t, J = 6.2 Hz, 1H). (E)-2-Cyano-3-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-3-methoxyphenyl)-N-(5-(trifluoromethyl)-1,3,4-thiadiazol-2yl)acrylamide, 18.…”

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confidence: 99%

Synthesis and Biological Evaluation of a c(RGDyK) Peptide Conjugate of SRPIN803

et al. 2021

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Strategies for Inhibition and Disaggregation of Amyloid‐β Fibrillation

et al. 2021

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Amyloid-β protein (Aβ) is a fatal cause of Alzheimer's disease, which can trigger a series of cytotoxicity by the abnormal aggregation of Aβ in human brain. The strategies for inhibition and disaggregation of Aβ fibrillation are mostly based on the interaction between monomers, oligomers, fibrils, and materials. This review summarizes recent researches of materials and regulation of interactions for inhibiting Aβ aggregation and disaggregating Aβ fibrils. The materials have been reviewed and divided into several kinds according to molecular type. And the regulation of interactions between materials and Aβ protein mainly focuses on covalent interaction, non-covalent interaction and photoactivated effect based on covalent and non-covalent interaction. In this review, the photodynamic effect and photothermal effect on regulation of Aβ aggregation are summarized in detail. In the end, the challenges and outlook of the application prospects on the strategies for inhibition and disaggregation of Aβ fibrillation are estimated.

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