Multiple institutions have explored accelerated partial breast irradiation (APBI). The method of APBI with the longest reported follow-up is multicatheter interstitial brachytherapy. Balloon brachytherapy was introduced to simplify the APBI procedure. The MammoSite device was the first breast brachytherapy device designed for the treatment of APBI to hit the market. The MammoSite catheter was adopted rapidly in both academic and community settings and has led to a great increase in the number of patients undergoing the APBI procedure. We introduce and describe five additional breast brachytherapy devices.