A double‐blind, placebo‐controlled study of a commercial <i> Aloe vera</i> gel in the treatment of slight to moderate psoriasis vulgaris

Paulsen, Evy; Korsholm, Lars; Brandrup, Flemming

doi:10.1111/j.1468-3083.2004.01186.x

Cited by 92 publications

(93 citation statements)

References 17 publications

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“…However, 55% of the patients reported local side-effects, mainly drying-up of the skin on test areas. The efficacy of treatment with Aloe vera gel was lower than treatment with placebo gel -a substance that only differed from the Aloe vera gel by the absence of the biologically active constituents [12].…”

Section: Wound Healingmentioning

confidence: 90%

“…Plaque psoriasis reduces score sum of erythema, infiltration and desquamation causes only local side-effects [12] Nappy dermatitis decreases severity of nappy dermatitis reduces rash does not cause any adverse effect [13] Vulval lichen planus results in a good response in patients with vulval lichen planus located on labia minora does not cause side-effects [16] Dry skin increases facial skin hydration levels increases arm skin hydration reduces wrinkle depth improves skin quality does not cause any adverse reactions improves skin integrity decreases appearance of fine wrinkling decreases erythema [18] [19]…”

Section: Skin and Mucosal Disordersmentioning

confidence: 99%

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Evaluation of clinical effectiveness of Aloe vera – a review

Zagórska‐Dziok¹,

Furman‐Toczek²,

Dudra-Jastrzębska³

et al. 2017

J Pre Clin Clin Res.

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Naturally occurring products have gained popularity in recent decades, especially due to their less adverse effects on human health. Various Aloe species are widespread all over the world. Aloe vera is one of the plants exhibiting multiple benefits and has gained considerable importance in clinical research. Historically, it has been used for a variety of medicinal purposes. It has attracted the attention of many researchers because of its different properties. More than 200 different biologically active substances were found in this plant that contributed to the fact it has been used to treat various types of diseases. The healthy effect of Aloe vera is primarily attributed to the polysaccharides contained in the gel of the leaves. It has been traditionally used to treat various conditions, including psoriasis, sunburn or radiation-related dermatitis, mucositis, oesophagitis or lichen planus. Aloe vera has also found application in wound healing, treatment of burns, protection against skin damage caused by X-ray, intestinal problems, reduction of plaque and gingivitis, regulating the levels of plasma lipoproteins, reduction of blood sugar levels and improving the immune system. Other biological activities of aloe, such as antifungal, antibacterial, antiviral, anti-inflammatory, anticancer and immunomodulatory have also been documented in numerous studies. This review examines the possible applications of Aloe vera in clinical trials.

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Section: Wound Healingmentioning

confidence: 90%

Section: Skin and Mucosal Disordersmentioning

confidence: 99%

Evaluation of clinical effectiveness of Aloe vera – a review

Zagórska‐Dziok¹,

Furman‐Toczek²,

Dudra-Jastrzębska³

et al. 2017

J Pre Clin Clin Res.

View full text Add to dashboard Cite

show abstract

“…There are two randomized placebo-controlled trials of aloe vera gel for the treatment of mild to moderate psoriasis with one showing beneficial effects 50 and the other showing no benefit over placebo. 51 There are numerous other non-medicated topical moisturizer compounds and formulations available; depending on the individual product, they can be applied up to several times daily. The goal of treatment with these agents is to provide and retain moisture in the stratum corneum; these agents are thought to function by forming a film on the skin surface to help retain moisture.…”

Section: Other Topical Treatmentsmentioning

confidence: 99%

Guidelines of care for the management of psoriasis and psoriatic arthritis

Menter

Korman

Elmets

et al. 2009

Journal of the American Academy of Dermatology

433

190

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“…Clinical studies on the use of Aloe vera preparations in plaque psoriasis are few in number; Syed et al (1996) and Choonhakarn et al (2010) agree on its efficacy in topical applications, reporting improvement of PASI and DLQI scores (more than with placebo, but less than with steroids); but there is also conflicting data Paulsen et al (2005). Therefore, although there are some promising data, clinical effectiveness needs more scientific confirmation.…”

mentioning

confidence: 99%

Pharmacological Benefits of Herbal Formulations in the Management of <i>Psoriasis vulgaris<i>

Boca

Tătaru

Pincelli

et al. 2014

Not Bot Hort Agrobot Cluj

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Psoriasis is a chronic inflammatory skin disease, with an important impact on the patient's quality of life. Its incidence and prevalence are continuously increasing. The complex ethiopathology of this disorder is only partially known; there is a clear genetic predisposition, which associates a number of environmental triggering factors such as an unbalanced diet and lifestyle. The conventional therapeutic options are not always satisfactory in terms of efficiency and safety, therefore, complementary and alternative medicine approaches are frequently chosen by patients, mostly as self-medication. This review, based on recent literature flow data, outlines the pharmacological benefits of herbal formulations with antipsoriatic activity. It also reveals the molecules responsible for their effects, as well as their interference with the metabolic and immunopathogenic mechanisms of this disease. An important number of plants have been proved to act as antipsoriatic agents, many botanical-based preparations containing keyphytochemical molecules (belonging mainly to phenolics, triterpenoids and phytosterols or unsaturated fatty acids, as mentioned in specific phyto-pharmaceutical databases). Specific mechanisms of action, which can explain their activity (such as lipoxygenase inhibition, antioxidant, anti-inflammatory, anti prostaglandin), were recently described. Only some of these formulations have been actively tested in vitro or in vivo. Most publications in the field agree on the need for more in vitro and in vivo studies, especially clinical assessment on patients with Psoriasis vulgaris. These would provide more accurate data on the efficacy and safety of such herbal formulations for this disease.

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A double‐blind, placebo‐controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris

Abstract: The effect of this commercial Aloe vera gel on stable plaque psoriasis was modest and not better than placebo. However, the high response rate of placebo indicated a possible effect of this in its own right, which would make the Aloe vera gel treatment appear less effective.

Cited by 92 publications

References 17 publications

Evaluation of clinical effectiveness of Aloe vera – a review

Evaluation of clinical effectiveness of Aloe vera – a review

Guidelines of care for the management of psoriasis and psoriatic arthritis

Pharmacological Benefits of Herbal Formulations in the Management of <i>Psoriasis vulgaris<i>

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