A double blind randomized clinical trial to investigate the effect of vitamin D supplementation on metabolic and hepato-renal markers in type 2 diabetes and obesity

Safarpour, Peivasteh; Vafa, Mohammadreza; Amiri, Fatemehsadat; Janani, Leila; Noorbakhsh, Mitra; Nikoo, Ensieh Rajabpour; Sadeghi, Homa

doi:10.14196/mjiri.32.34

Cited by 11 publications

(7 citation statements)

References 40 publications

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“…Detailed characteristics of included studies are presented in Table 1 . Overall, most of the studies (n = 13) were conducted in Asia ( 12 , 26 , 29 , 30 , 32 , 33 , 35 , 37 – 39 , 41 , 42 , 44 ). Thirteen studies clarified using vitamin D3 as their supplementation ( 12 , 26 – 32 , 34 – 36 , 40 , 43 ), while the remaining 7 studies did not specify the type of vitamin D ( 33 , 37 – 39 , 41 , 42 , 44 ).…”

Section: Resultsmentioning

confidence: 99%

“…Eighty-eight articles were assessed for eligibility, and an additional 68 studies were excluded due to the following reasons: lacked information on lipid profiles, usage or doses of vitamin D supplementation, baseline 25OHD or BMI, or administration of vitamin D fortification (n = 47); inappropriate control or intervention group (n = 20); not mention the specific type of diabetes (n = 1). Finally, 20 articles with 24 effect sizes were included (12,(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44).…”

Section: Study Selectionmentioning

confidence: 99%

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The effects of vitamin D supplementation on serum lipid profiles in people with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Lu,

Liang,

2024

Front. Nutr.

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IntroductionPeople with type 2 diabetes (T2D) are highly susceptible to the development of cardiovascular diseases. Previous studies have suggested that the application of vitamin D may offer potential benefits in improving lipid profiles, but these effects remain controversial.MethodsThis systematic review and meta-analysis focused on the effects of vitamin D supplementation on serum lipid profiles in people with T2D. Randomized controlled trials (RCTs) assessing the effects of vitamin D supplementation on lipid profiles and published before September 19th, 2023, were identified in PubMed, Embase, and Cochrane Library. This review protocol was registered in the PROSPERO (CRD42023461136). The random-effects model was employed to estimate unstandardized mean differences (MD) and 95% confidence intervals (CIs). The quality of studies was assessed by the Cochrane Risk of Bias tool 2.ResultsOverall, 20 RCTs involving 1711 participants were included. Results indicated that vitamin D supplementation significantly improves serum high-density lipoprotein (HDL) (MD: 1.63 mg/dL, 95% CI: 0.19 to 3.08, P = 0.03), and triglyceride (TG) levels (MD: -8.56 mg/dL, 95% CI: -15.23 to -1.89, P = 0.01). However, vitamin D supplementation failed to improve low-density lipoprotein (LDL) levels and total cholesterol (TC) levels. Subgroup analyses and meta-regressions suggested that higher doses of vitamin D supplementation and shorter duration of intervention were more likely to have favorable effects on lipid profiles. Moreover, participants with lower baseline BMI and higher serum 25-hydroxy vitamin D levels exhibited greater improvements in lipid profiles following vitamin D supplementation.ConclusionsThis meta-analysis highlighted the effects of vitamin D supplementation on improving serum HDL and TG levels while not exhibiting significant improvements in LDL and TC levels. Further long-term and high-quality studies are still needed to draw more precise conclusions.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=461136.

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Section: Resultsmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

The effects of vitamin D supplementation on serum lipid profiles in people with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Lu,

Liang,

2024

Front. Nutr.

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“…Otherwise, VD supplementation enhanced the anti-inflammatory endogenous mechanisms in the kidney in different diseases (51,52) .…”

Section: Discussionmentioning

confidence: 98%

“…Our results are in line with previous reports, that showed significant reduction in MDA levels, as well as the proinflammatory cytokines IL1β, IL6, IFN-γ and IL17A in paracetamol group. The hepatic and renal tissue proteins of the GPx enzymes in addition to the anti-inflammatory cytokine IL10 (38,51) . Moreover, Vitamin-D correlated significantly and positively with the antioxidative indicators and anti-inflammatory cytokines, whereas inverse significant correlations were observed with the pro-oxidant and proinflammatory molecules.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Ameliorates Oxidative and Inflammatory Effects of Hepatorenal Injury of Acute Paracetamol Toxicity: An experimental study

Elsaeed

Gawesh

Hammad

et al. 2020

SJMS

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Introduction and aim: An accidental or intentional paracetamol overdosage is a common condition, with hepatic injury as a common complication. Kidney could be injured in association with hepatic injury. Prevention and/or proper treatment is markedly important. The current study aimed to investigate the role of vitamin D (VD) in acute paracetamol-induced hepatorenal damage. Methodology: Fourty male Wister rats were divided into 4 equal groups. The negative control (NC), the positive control (PC) (received paracetamol 1200mg/kg), prophylactic group (received VD (1000 IU/Kg/day) before induction of toxicity and treatment continued after induction); and the treatment group with VD (2000 IU/Kg/day) for five successive days after induction of toxicity, for three successive cycles. VD levels, serum liver enzymes, total protein, albumin, serum urea and creatinine were estimated. The concentrations of interferon-γ (IFN- γ), interleukins (IL1β, IL4, IL10, and IL-17) in the tissue lysate were determined. The oxidative stress indicators and antioxidant enzymes (glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), glutathione (GSH) and Malonaldehyde (MDA)) were also measured. Results: Liver enzymes, serum urea and creatinine were increased in PC than NC groups, and were significantly reduced in prophylactic and treatment groups. But not return normal values, and prophylactic group is better. Total proteins and albumin significantly reduced by paracetamol toxicity and returned to near normal with VD supplementation. Vitamin-D levels were significantly reduced in PC than NC groups. However, it was significantly increased in prophylactic and treatment groups than NC and PC groups. IFN- γ, IL-1β, IL-17, and MDA were significantly increased, while IL-10, GPx, CAT, and GSH were significantly reduced in PC than NC groups. Prophylactic and treatment groups improved the values. However, SOD significantly reduced in PC than NC group. Vitamin D was significantly and inversely correlated with ALT, AST, ALP, albumin, creatinine, liver and kidney IFN-γ, IL-1β, IL-17 and MDA. But, it was proportionately and significantly correlated with liver and kidney IL-10. Conclusion: Acute paracetamol toxicity alters hepatic and renal VD homeostasis through oxidative stress and pro-inflammation. Vitamin D supplementation had an ameliorative action on hepatorenal injury, and the long duration of VD supplementation had better outcome.

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“…A prospective study showed that coronary syndrome patients with low serum 25 (OH)D levels had a higher incidence of in-hospital complications and mortality [ 31 ]. Another study recruited 90 T2DM patients with serum 25 (OH)D levels less than 30 ng/ml, added 50000 IU vitamin D for eight weeks, and results showed a significant increase in serum vitamin D levels, decrease in serum HbA1c levels, and increase in HDL-cholesterol levels [ 32 ]. This experiment proved that vitamin D supplements can improve HbA1c and lipid metabolism in patients with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Serum Cortisol, 25 (OH)D, and Cardiovascular Risk Factors in Patients with Type 2 Diabetes Mellitus

Jin

Wei

Liu

et al. 2022

International Journal of Endocrinology

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Background and Aims. The effects of cortisol on cardiovascular diseases (CVD) and CVD risk are unknown, especially in patients with type 2 diabetes mellitus (T2DM). Furthermore, it is unclear whether 25 (OH)D can alter the associations of cortisol with CVD and CVD risk factors. Thus, the present study was to investigate the associations of serum cortisol with CVD and CVD risk factors and whether 25 (OH)D altered these associations among patients with T2DM. Materials and methods. A total of 762 patients diagnosed with T2DM were recruited. The levels of serum cortisol and 25 (OH)D were measured with a liquid chromatography-tandem mass spectrometry. Logistic regression and linear regression were used to assess the association of cortisol with CVD and multiple cardiovascular risk factors. Modification analyses were performed to identify whether 25 (OH)D altered the above associations. Results. A 1 SD increase in cortisol was associated with a higher prevalence of stroke (odds ratio (OR): 1.25, 95% confidence interval (CI): 1.05, 1.50). Elevated cortisol was associated with related cardiovascular risk factors, including deceased ß cell function, high-density lipoprotein-cholesterol (HDL-C), and fasting insulin, as well as increased triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c). In addition, modification analyses suggested that the associations of cortisol with ß cell function, fasting insulin, FPG, and HbA1c were modified by 25 (OH)D. Conclusions. Serum cortisol was associated with the prevalence of stroke and cardiovascular risk factors, and the associations of cortisol with cardiovascular risk factors were moderated by 25 (OH)D, suggesting that T2DM patients with exposure to lower 25 (OH)D levels and higher cortisol levels were more susceptible to have higher cardiovascular risk factors.

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A double blind randomized clinical trial to investigate the effect of vitamin D supplementation on metabolic and hepato-renal markers in type 2 diabetes and obesity

Cited by 11 publications

References 40 publications

The effects of vitamin D supplementation on serum lipid profiles in people with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

The effects of vitamin D supplementation on serum lipid profiles in people with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Vitamin D Ameliorates Oxidative and Inflammatory Effects of Hepatorenal Injury of Acute Paracetamol Toxicity: An experimental study

Serum Cortisol, 25 (OH)D, and Cardiovascular Risk Factors in Patients with Type 2 Diabetes Mellitus

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