A double-blind randomized trial: prophylactic vasopressin reduces hypotension after cardiopulmonary bypass

Morales, David L.S.; Garrido, Mauricio; Madigan, John D.; Helman, David; Faber, J.; Williams, Mathew; Landry, Donald W.; Öz, Mehmet C.

doi:10.1016/s0003-4975(02)04408-9

Cited by 95 publications

(51 citation statements)

References 19 publications

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“…However, AVP therapy in vasodilatory shock, at a dosage of 0.03-0.07 U/min, increases the plasma concentration to a range of 100-290 pg/ml (approximately up to 3 9 10 -10 M) [10,24,25]. Thus, the AVP concentrations used in the present study are more than 100-fold higher than the clinical concentrations.…”

Section: Discussionmentioning

confidence: 58%

“…AVP plays an important role in maintaining systemic blood pressure under both physiological and pathophysiological conditions [9]. Moreover, the intravenous infusion of a small dose of AVP has been used to treat refractory vasodilatory shock after cardiopulmonary bypass [10,11] and to treat anaphylactic shock [12][13][14] during general anesthesia. However, little information is available regarding the influence of general anesthetics on AVPinduced vasoconstriction.…”

Section: Introductionmentioning

confidence: 99%

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The cellular mechanisms underlying the inhibitory effects of isoflurane and sevoflurane on arginine vasopressin-induced vasoconstriction

et al. 2010

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

The cellular mechanisms underlying the inhibitory effects of isoflurane and sevoflurane on arginine vasopressin-induced vasoconstriction

et al. 2010

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“…100 Other potential clinical uses of AVP still under evaluation, and not the focus of this review, include weaning from extracorporeal circulation, out of hospital cardiac arrest, and pulseless ventricular arrhythmia. [102][103][104] …”

Section: Discussionmentioning

confidence: 99%

Review article: Organ per fusion/permeabilityrelated effects of norepinephrine and vasopressin in sepsis

Farand¹,

Hamel

Lauzier

et al. 2006

Can J Anesth/J Can Anesth

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Purpose:One invariable hallmark of severe sepsis is generalized tissue "malperfusion" and hyperpermeability secondary to microcirculatory/capillary leakage. This review focuses on direct and/or indirect influences of norepinephrine, as a standard of care, and vasopressin, as an alternative vasoactive drug, on organ and tissue perfusion/permeability in severe sepsis.Source: English and French language articles and books published between 1966 and 2005 were identified through a computerized Medline search using the terms "sepsis, permeability, norepinephrine and vasopressin". Relevant publications were retrieved and scanned for additional sources. Principal findings:There are few randomized clinical trials comparing different vasopressors in sepsis; most available literature consists of clinical reports, animal experiments and occasional reviews. Based on the best current evidence from these sources, we describe the status of major organ perfusion/ permeability in sepsis (i.e., the lung, the kidney, the heart, the intestine/gut) in the context of sepsis-induced organ dysfunction/failure. Potential and differential therapeutic effects of the vasopressors norepinephrine and arginine-vasopressin, in the setting of sepsis, are identified. Conclusions:In the treatment of sepsis, arginine-vasopressin exhibits organ-specific heterogeneity in vascular responsiveness, compared to norepinephrine. While norepinephrine is a current standard of care in sepsis, arginine-vasopressin shows promise for the treatment of septic shock. Objectif

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“…Although catecholamine therapy is often ineffective, methylene blue (through a nitric oxide-inhibition mechanism) and vasopressin have been shown to improve outcomes. [65][66][67] …”

Section: Postoperative Cardiac Surgerymentioning

confidence: 99%

Inotropes and Vasopressors

2008

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A double-blind randomized trial: prophylactic vasopressin reduces hypotension after cardiopulmonary bypass

Cited by 95 publications

References 19 publications

The cellular mechanisms underlying the inhibitory effects of isoflurane and sevoflurane on arginine vasopressin-induced vasoconstriction

The cellular mechanisms underlying the inhibitory effects of isoflurane and sevoflurane on arginine vasopressin-induced vasoconstriction

Review article: Organ per fusion/permeabilityrelated effects of norepinephrine and vasopressin in sepsis

Inotropes and Vasopressors

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