A double‐blinded, randomized, controlled, crossover evaluation of a zinc methionine supplement as an adjunctive treatment for canine atopic dermatitis

McFadden, Rendina A; Heinrich, Nicole A.; Haarstad, Amy C.; Tomlinson, D.J.

doi:10.1111/vde.12466

Cited by 13 publications

(10 citation statements)

References 18 publications

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“…One randomized, double-blinded, placebo-controlled study showed an ameliorative effect of zinc methionine supplementation in dogs with mild to moderate, chronic, non-seasonal AD, receiving either cyclosporine or glucocorticoids [107].…”

Section: Vitamins and Mineralsmentioning

confidence: 99%

Impact of Nutritional Supplementation on Canine Dermatological Disorders

Marchegiani

Fruganti

Spaterna

et al. 2020

Veterinary Sciences

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Nutritional supplements, also known as complementary feeds, are products administered with the aim of furnishing health benefits, regardless of nutritional needs. They have been used since ancient times in veterinary dermatology, and a number of studies have focused on investigating the health benefits of some ingredients found in commercially available complementary feed for dogs. The aim of this paper is to review the literature available on the use of nutritional supplementation for the management of canine skin diseases, critically appraising the clinical efficacy of such interventions and summarizing the current state of knowledge. This review highlights how these feeds can be considered useful in the management of dermatological disorders and outlines their beneficial effects in the prevention of dietary deficiencies and treatment of diseases, alone, or in addition to conventional pharmacological therapy. In recent years, nutritional supplements have found increasing potential application in veterinary medicine, and the scientific proofs of their beneficial effects are described in this review.

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Section: Vitamins and Mineralsmentioning

confidence: 99%

Impact of Nutritional Supplementation on Canine Dermatological Disorders

Marchegiani

Fruganti

Spaterna

et al. 2020

Veterinary Sciences

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“…In a randomized controlled trial investigating the efficacy of an oral fatty acid, vitamin and zinc supplement in 26 dogs with AD sensu lato, which were already controlled with prednisolone or cyclosporine, the administration of systemic antimicrobials for the treatment of bacterial and yeast infections that occurred during the trial was not associated with a significant improvement of skin lesions (assessed by Canine Atopic Dermatitis Lesion Index) or with a clear-cut reduction of PVAS [ 22 ]. In an open trial, the administration of systemic antibacterials in 14 dogs with AD sensu lato and superficial bacterial pyoderma for 4–6 weeks did not result in the significant improvement of skin lesions that were assessed by a modified regional CADESI-3 (i.e., the older iteration of CADESI that has different sensitivity to change compared to CADESI-4) scoring system [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although treatment of bacterial overgrowth/infection and of Malassezia dermatitis in dogs with AD has been recommended [ 18 , 19 , 20 ] and is widely practiced, there are few studies evaluating its efficacy [ 11 , 21 , 22 , 23 ], and none of them report all currently proposed outcome measures for therapeutic trials on canine AD, including the improvement of skin lesions, the improvement of pruritus, and the owner’s assessment of treatment efficacy [ 24 ]. Thus, the aim of this open, observational, combined prospective, and retrospective study was to evaluate the changes in the severity of skin lesions and pruritus, as well as the investigator’s and owner’s assessment of the efficacy of antimicrobial treatment in dogs with AD and skin infections.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Antimicrobial Treatment in Dogs with Atopic Dermatitis: An Observational Study

Sofou

Aleksandrova

Badulescu

et al. 2022

Veterinary Sciences

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There is a shortage of studies reporting the efficacy of antimicrobial treatment of dogs with atopic dermatitis (AD) and skin infections (SIs). The aim of this study was to evaluate the change in the severity of skin lesions and pruritus, and the overall efficacy of antimicrobial treatment, in dogs with AD and bacterial overgrowth/infection and/or Malassezia dermatitis. A total of 20 dogs with AD and SIs were prospectively enrolled (group A) and they were examined before and after the administration of systemic antimicrobials that resulted in the resolution of SIs. In addition, 19 dogs fulfilling the same inclusion criteria and treated with systemic, with or without topical antimicrobials, were included retrospectively (group B). Since there were no major differences between the groups, their results were combined. The severity of skin lesions decreased significantly, by 30% based on Canine Atopic Dermatitis Extent and Severity Index-4 (CADESI-4), by 28.1% based on the erythema domain of CADESI-4 and based on owner’s global assessment of the severity of skin lesions. Pruritus decreased significantly, by 34.7% based on the Pruritus Visual Analogue Scale (PVAS). The efficacy of antimicrobial treatment was assessed as good to excellent by the investigator and the owner in 55% and 60% of the dogs, respectively. Despite the significant improvement, there was high variability in the response to treatment among dogs. Further studies are needed to find factors that determine the response to antimicrobial treatment in dogs with AD and SIs.

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“…Canine atopic dermatitis is a chronic genetically predisposed, inflammatory, and pruritic skin disorder, that likely accompanies dogs throughout life [120]. McFadden et al reported that dogs affected with the disease improved clinical signs (lower Canine Atopic Dermatitis Lesion Index) by receiving allergen treatment (glucocorticoids or ciclosporin) associated with a zinc-containing supplement (zinc methionine, eicosapentaenoic acid, docosahexaenoic acid, and biotin) when compared to dogs receiving the same medication associated to an identical supplement but without zinc methionine [121]. Moreover, dogs that received glucocorticoids combined with the zinc-containing supplement, presented less pruritus, and a reduction of medication was possible for at least four weeks, comparing with dogs receiving ciclosporin and the zinc-containing supplement, which suggests that glucocorticoids enhance zinc absorption [121].…”

Section: Canine Atopic Dermatitismentioning

confidence: 99%

Zinc in Dog Nutrition, Health and Disease: A Review

Pereira

Maia

Fonseca

et al. 2021

Animals

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Zinc is an essential trace element, required for enzymatic, structural, and regulatory functions. As body reserves are scarce, an adequate zinc status relies on proper dietary supply and efficient homeostasis. Several biomarkers have been proposed that enable the detection of poor zinc status, but more sensitive and specific ones are needed to detect marginal deficiencies. The zinc content of commercial dry dog foods has great variability, with a more frequent non-compliance with the maximum authorized limit than with the nutritional requirement. The bioavailability of dietary zinc also plays a crucial role in ensuring an adequate zinc status. Despite controversial results, organic zinc sources have been considered more bioavailable than inorganic sources, albeit the zinc source effect is more evident after a restriction period of dietary zinc. Many disorders have been associated with inadequate zinc status, not being clear whether the occurrence of the disease is the consequence or the cause. This review presents data on zinc requirements and biomarkers for zinc status, that can be applied for the development of supplementation strategies of zinc in complete pet foods. Moreover, it provides an understanding of the role zinc plays in the health of dogs, and how altered zinc status affects diseases in dogs.

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A double‐blinded, randomized, controlled, crossover evaluation of a zinc methionine supplement as an adjunctive treatment for canine atopic dermatitis

Abstract: This study supports a potential benefit of adjunctive zinc methionine supplementation in CAD. Dogs receiving glucocorticoids may be more likely to benefit. Further studies are needed to substantiate these initial results.

Cited by 13 publications

References 18 publications

Impact of Nutritional Supplementation on Canine Dermatological Disorders

Impact of Nutritional Supplementation on Canine Dermatological Disorders

Efficacy of Antimicrobial Treatment in Dogs with Atopic Dermatitis: An Observational Study

Zinc in Dog Nutrition, Health and Disease: A Review

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