A dual-gelling poly(N-isopropylacrylamide)-based ink and thermoreversible poloxamer support bath for high-resolution bioprinting

Navara, Adam M.; Kim, Yu Seon; Xu, Yilan; Crafton, Christopher L.; Diba, Mani; Guo, Jason L; Mikos, Antonios G.

doi:10.1016/j.bioactmat.2021.11.016

Cited by 17 publications

(25 citation statements)

References 34 publications

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“…Alkali-burn-induced corneal neovascularization [130] Pluronic ® F127, PLGA-PEG-PLGA Salinomycin Glioblastoma therapy [131] PCL-PEG-PCL Diclofenac sodium Anti-inflammatory and analgesic [132] PLGA-PEG-PLGA Curcumin, Doxorubicin Localized administration for osteosarcoma [133] PLGA-PEG-PLGA Corilagin, chitosan Localized cancer therapy [134] Good temperature sensitivity, simple preparation, easy availability of materials, numerous modified monomers, crosslinking with a variety of temperature-sensitive materials, and rich functional properties poly(Nisopropylacrylamide) Cell High-resolution bioprinting [134] poly(Nisopropylacrylamide) / Immunoglobulin G (IgG) purification [135] poly(Nisopropylacrylamide) Diclofenac sodium (DS) Skin reinfection [136] poly(Nisopropylacrylamide)…”

Section: Osteoarthritismentioning

confidence: 99%

Thermosensitive Hydrogels and Advances in Their Application in Disease Therapy

et al. 2022

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Thermosensitive hydrogels, having unique sol–gel transition properties, have recently received special research attention. These hydrogels exhibit a phase transition near body temperature. This feature is the key to their applications in human medicine. In addition, hydrogels can quickly gel at the application site with simple temperature stimulation and without additional organic solvents, cross-linking agents, or external equipment, and the loaded drugs can be retained locally to improve the local drug concentration and avoid unexpected toxicity or side effects caused by systemic administration. All of these features have led to thermosensitive hydrogels being some of the most promising and practical drug delivery systems. In this paper, we review thermosensitive hydrogel materials with biomedical application potential, including natural and synthetic materials. We describe their structural characteristics and gelation mechanism and briefly summarize the mechanism of drug release from thermosensitive hydrogels. Our focus in this review was to summarize the application of thermosensitive hydrogels in disease treatment, including the postoperative recurrence of tumors, the delivery of vaccines, the prevention of postoperative adhesions, the treatment of nervous system diseases via nasal brain targeting, wound healing, and osteoarthritis treatment.

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Section: Osteoarthritismentioning

confidence: 99%

Thermosensitive Hydrogels and Advances in Their Application in Disease Therapy

et al. 2022

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“…Because of the bioink requirements for printability and cellular biocompatibility, relatively few biomaterials may be utilized as bioink ingredients for bioprinting applications. − Commonly adopted biomaterials for bioprinting include natural and synthetic methacrylate-conjugated macromolecules, alginates, gelatins, collagens, and decellularized matrices. − In terms of the bioinks based on these materials, the composition ratios and concentrations of materials are normally only adjustable within a narrow range to avoid a reduction in bioink printability or a reduction of cellular biocompatibility. Furthermore, a high-resolution scaffold printing is an ongoing target for bioprinting-based applications where techniques are constantly being realized and refined for producing constructs with a high fidelity. , For the survival and biofunctions of cells distributed within scaffold fibers, cells rely on nutrient uptake and metabolite excretion from the external cell culture environment. Thick scaffold fibers are often not fully permissive to the exchange of molecules between the cells located in the central and peripheral regions of 3D scaffolds, leading to a reduction in overall cell viability, especially within the deep regions of large-scaled printed constructs.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, a high-resolution scaffold printing is an ongoing target for bioprinting-based applications where techniques are constantly being realized and refined for producing constructs with a high fidelity. 19,20 For the survival and biofunctions of cells distributed within scaffold fibers, cells rely on nutrient uptake and metabolite excretion from the external cell culture environment. Thick scaffold fibers are often not fully permissive to the exchange of molecules between the cells located in the central and peripheral regions of 3D scaffolds, leading to a reduction in overall cell viability, especially within the deep regions of large-scaled printed constructs.…”

Section: Introductionmentioning

confidence: 99%

Infiltration from Suspension Systems Enables Effective Modulation of 3D Scaffold Properties in Suspension Bioprinting

Wang

Honiball

Lin

et al. 2022

ACS Appl. Mater. Interfaces

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Bioprinting is a biofabrication technology which allows efficient and large-scale manufacture of 3D cell culture systems. However, the available biomaterials for bioinks used in bioprinting are limited by their printability and biological functionality. Fabricated constructs are often homogeneous and have limited complexity in terms of current 3D cell culture systems comprising multiple cell types. Inspired by the phenomenon that hydrogels can exchange liquids under the infiltration action, infiltration-induced suspension bioprinting (IISBP), a novel printing technique based on a hyaluronic acid (HA) suspension system to modulate the properties of the printed scaffolds by infiltration action, was described in this study. HA served as a suspension system due to its shear-thinning and self-healing rheological properties, simplicity of preparation, reusability, and ease of adjustment to osmotic pressure. Changes in osmotic pressure were able to direct the swelling or shrinkage of 3D printed gelatin methacryloyl (GelMA)-based bioinks, enabling the regulation of physical properties such as fiber diameter, micromorphology, mechanical strength, and water absorption of 3D printed scaffolds. Human umbilical vein endothelial cells (HUVEC) were applied as a cell culture model and printed within cell-laden scaffolds at high resolution and cell viability with the IISBP technique. Herein, the IISBP technique had been realized as a reliable hydrogel-based bioprinting technique, which enabled facile modulation of 3D printed hydrogel scaffolds properties, being expected to meet the scaffolds requirements of a wide range of cell culture conditions to be utilized in bioprinting applications.

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“…A total of 24 articles [ [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] ] are included in this special issue. These articles can be categorized in terms of authors, biomaterials and targeted clinical areas, and article types.…”

mentioning

confidence: 99%

“…Several articles in this special issue are on regulatory science and discuss the new standards, tools, and approaches to evaluate the safety, efficacy, quality, and performance of medical products [ 10 , 13 , 17 , 19 ]. This special issue also covers a wide range of article types including research article [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , 11 , 12 , 15 , 16 , [18] , [19] , [20] , [23] , [24] , [25] , [26] ], reviews [ 14 , 17 , 21 , 22 , 27 ], perspectives [ 10 , 13 ] and opinion paper [ 18 ].…”

mentioning

confidence: 99%