A dual ligand targeted nanoprobe with high MRI sensitivity for diagnosis of breast cancer

Gong, Faming; Zhang, Zuo-quan; Chen, Xiao; Zhang, Lu; Yu, Xingsu; Yang, Qin; Shuai, Xintao; Liang, Beibei; Cheng, Du

doi:10.1007/s10118-014-1399-8

Cited by 14 publications

(1 citation statement)

References 26 publications

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“…Compared to terminal linear PEG, the branched and comb-like terminal ones showed higher circulation half-life and serum stability [ 27 ]. Besides, the targeting ligands, including small molecules (e.g., folate), peptides (e.g., iRGD), and antibody fragments (e.g., Her2 antibody), have been introduced to the surface of nanoparticles to enhance targeting delivery efficiency [ 28 , 29 , 30 , 31 ]. Thus, the surface properties of nanoparticles play important roles in achieving excellent siRNA delivery efficiency.…”

Section: Introductionmentioning

confidence: 99%

Size- and Surface- Dual Engineered Small Polyplexes for Efficiently Targeting Delivery of siRNA

Liu

Deng

et al. 2021

Molecules

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Though siRNA-based therapy has achieved great progress, efficient siRNA delivery remains a challenge. Here, we synthesized a copolymer PAsp(-N=C-PEG)-PCys-PAsp(DETA) consisting of a poly(aspartate) block grafted with comb-like PEG side chains via a pH-sensitive imine bond (PAsp(-N=C-PEG) block), a poly(l-cysteine) block with a thiol group (PCys block), and a cationic poly(aspartate) block grafted with diethylenetriamine (PAsp(DETA) block). The cationic polymers efficiently complexed siRNA into polyplexes, showing a sandwich-like structure with a PAsp(-N=C-PEG) out-layer, a crosslinked PCys interlayer, and a complexing core of siRNA and PAsp(DETA). Low pH-triggered breakage of pH-sensitive imine bonds caused PEG shedding. The disulfide bond-crosslinking and pH-triggered PEG shedding synergistically decreased the polyplexes’ size from 75 nm to 26 nm. To neutralize excessive positive charges and introduce the targeting ligand, the polyplexes without a PEG layer were coated with an anionic copolymer modified with the targeting ligand lauric acid. The resulting polyplexes exhibited high transfection efficiency and lysosomal escape capacity. This study provides a promising strategy to engineer the size and surface of polyplexes, allowing long blood circulation and targeted delivery of siRNA.

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Section: Introductionmentioning

confidence: 99%

Size- and Surface- Dual Engineered Small Polyplexes for Efficiently Targeting Delivery of siRNA

Liu

Deng

et al. 2021

Molecules

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Aggregation‐Induced Emission Luminogens: Union Is Strength, Gathering Illuminates Healthcare

Chen

Ding

et al. 2018

Adv Healthcare Materials

135

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The rapid development of healthcare techniques encourages the emergence of new molecular imaging agents and modalities. Fluorescence imaging that enables precise monitoring and detection of biological processes/diseases is extensively investigated as this imaging technique has strengths in terms of high sensitivity, excellent temporal resolution, low cost, and good safety. Aggregation-induced emission luminogens (AIEgens) have recently emerged as a new class of emitters that possess several notable features, such as high brightness, large Stokes shift, marked photostability, good biocompatibility, and so on. So far, AIEgens are widely explored and exhibit superb performance in the area of biomedicine and life sciences. Herein, this review summarizes and discusses the recent investigations of AIEgens for in vivo diagnosis and therapy including long-term tracking, 3D angiography, multimodality imaging, disease theranostics, and activatable sensing. Collectively, these results reveal that AIEgens are of great promise for in vivo biomedical applications. It is hoped that this review will lead to new insights into the development of advanced healthcare materials.

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Inorganic nanoparticles in diagnosis and treatment of breast cancer

2018

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Nanoparticles are being actively developed for biomolecular profiling of cancer biomarkers, tumor imaging in vivo, and targeted drug delivery. These nanotechnology-based techniques can be applied widely in the management of different malignant diseases, such as breast cancer. Although the number of different types of nanoparticles is increasing rapidly, most can be classified into two major types: particles that contain organic molecules as a major building material (such as dendrimers, micelles, liposomes and carbon nanotubes, and other polymers); and those that use inorganic elements, usually metals, as a core. In particular, inorganic nanoparticles have received increased attention in the recent past as potential diagnostic and therapeutic systems in the field of oncology. This review primarily discusses progress in applications of inorganic nanoparticles for breast cancer imaging and treatment.

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A dual ligand targeted nanoprobe with high MRI sensitivity for diagnosis of breast cancer

Cited by 14 publications

References 26 publications

Size- and Surface- Dual Engineered Small Polyplexes for Efficiently Targeting Delivery of siRNA

Size- and Surface- Dual Engineered Small Polyplexes for Efficiently Targeting Delivery of siRNA

Aggregation‐Induced Emission Luminogens: Union Is Strength, Gathering Illuminates Healthcare

Inorganic nanoparticles in diagnosis and treatment of breast cancer

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