A Dual‐Nanozyme‐Catalyzed Cascade Reactor for Enhanced Photodynamic Oncotherapy against Tumor Hypoxia

Chen, Miaomiao; Song, Ji-Tao; Zhu, Jialong; Hong, Gaobo; An, Jing; Feng, Enmin; Peng, Xiaojun; Song, Fengling

doi:10.1002/adhm.202101049

Cited by 54 publications

(35 citation statements)

References 44 publications

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“…As illustrated in Scheme A, CaO 2 nanoparticles (NPs) were first prepared and followed by loading an efficient photosensitizer 4-DCF-MPYM (4-FM), a thermally activated delayed fluorescence (TADF) fluorescein derivative. These TADF molecules are enabled with a more efficient intersystem crossing (ISC) and a higher 1 O 2 quantum yield, which is promising for PDT. , Subsequently, the CaO 2 -FM core was encapsulated with copper ions (Cu 2+ ) and a tetrasulfide bond-doped intelligent organosilica shell (Cu-ONS). Compared with the typical Fenton reagent Fe 2+ , Cu + -catalysis Fenton-like reactions can occur in weakly acidic and neutral conditions with a much higher reaction rate (1 × 10 4 M –1 s –1 ) than that of Fe 2+ (63–76 M –1 s –1 ) .…”

Section: Introductionmentioning

confidence: 99%

Open-Source and Reduced-Expenditure Nanosystem with ROS Self-Amplification and Glutathione Depletion for Simultaneous Augmented Chemodynamic/Photodynamic Therapy

Chen

Zhao

Zhu

et al. 2022

ACS Appl. Mater. Interfaces

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Reactive oxygen species (ROS)-induced cell apoptosis has emerged as an efficient strategy for cancer therapy. However, tumor hypoxia and insufficient amounts of endogenous hydrogen peroxide (H 2 O 2 ) in the tumor microenvironment are currently the main limitations of photodynamic therapy (PDT) and chemodynamic therapy (CDT). Moreover, the glutathione (GSH) scavenging effect on ROS further hinders the efficiency of ROS-mediated therapy. Here, a CaO 2 -based nanosystem (named as CF@CO@HC) with ROS self-amplification and GSH-depletion abilities was developed by a bottom-up approach. This hybrid nanoparticle consisted of a photosensitizer-doped calcium peroxide (CaO 2 ) core (CaO 2 -FM), a hybrid organosilica framework (Cu-ONS) incorporated with Fenton reagents (Cu 2+ ) and tetrasulfide groups, and a local hydrophobic cage (HC) shell. The photosensitizer was fluorescein derivative 4-FM with a thermally activated delayed fluorescence (TADF) property. The HC shell was built to protect the CaO 2 and the photosensitizer from being attacked by water. Upon being internalized into cancer cells, the nanosystem was decomposed through the reduction reactions of Cu 2+ and the tetrasulfide bond-doped silica shell by GSH, thus releasing Cu + for Cu + -mediated CDT. Meanwhile, the exposed CaO 2 -FM can react with H 2 O to liberate photosensitizer 4-FM and generate H 2 O 2 and O 2 to overcome barriers in CDT and PDT. Thus, our study provided an open-source and reduced-expenditure strategy via GSH depletion and ROS self-amplification behaviors for ROS generation and significantly achieved an improved synergistic PDT/CDT for cancers.

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Section: Introductionmentioning

confidence: 99%

Open-Source and Reduced-Expenditure Nanosystem with ROS Self-Amplification and Glutathione Depletion for Simultaneous Augmented Chemodynamic/Photodynamic Therapy

Chen

Zhao

Zhu

et al. 2022

ACS Appl. Mater. Interfaces

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“…Among the metal-based materials for generating oxygen through H 2 O 2 decomposition, MnO 2 is a widely studied material [ 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 ]. MnO 2 could produce oxygen and Mn 2+ at acidic pH, particularly in the presence of H 2 O 2 .…”

Section: Strategies For Modulating Tumor Hypoxia In Pdtmentioning

confidence: 99%

Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

Liang

Luo

et al. 2022

Biomolecules

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Photodynamic therapy (PDT) is a treatment modality that uses light to target tumors and minimize damage to normal tissues. It offers advantages including high spatiotemporal selectivity, low side effects, and maximal preservation of tissue functions. However, the PDT efficiency is severely impeded by the hypoxic feature of tumors. Moreover, hypoxia may promote tumor metastasis and tumor resistance to multiple therapies. Therefore, addressing tumor hypoxia to improve PDT efficacy has been the focus of antitumor treatment, and research on this theme is continuously emerging. In this review, we summarize state-of-the-art advances in strategies for overcoming hypoxia in tumor PDTs, categorizing them into oxygen-independent phototherapy, oxygen-economizing PDT, and oxygen-supplementing PDT. Moreover, we highlight strategies possessing intriguing advantages such as exceedingly high PDT efficiency and high novelty, analyze the strengths and shortcomings of different methods, and envision the opportunities and challenges for future research.

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“…The experiment was carried out according to the methods reported in previous literature studies. ,, The detailed experimental procedures can be found in the Supporting Information.…”

Section: Experimental Sectionmentioning

confidence: 99%

Liposome-Based Nanoencapsulation of a Mitochondria-Stapling Photosensitizer for Efficient Photodynamic Therapy

Tian

Chen

et al. 2022

ACS Appl. Mater. Interfaces

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Mitochondria-targeting photodynamic therapy (PDT) can block mitochondrial function and trigger the inherent proapoptotic cascade signal of mitochondria, which has been considered to have the potential to amplify the efficiency of PDT. However, the dynamic change of mitochondrial membrane potential (MMP) makes most cationic photosensitizers easily fall off from the mitochondria, which greatly limits the efficiency of PDT. Here, we have developed a smart liposome encapsulation method based on a mitochondria-stapling photosensitizer for efficient theranostic photodynamic therapy. The stapling photosensitizer can be covalently bound inside mitochondria via two reaction sites without a falloff effect, regardless of the change of MMP. As a result, the liposome-based nanophotosensitizer showed a high efficiency of PDT (IC50 = 0.98 μM) under 630 nm light. At the same time, the nanophotosensitizer had fluorescence imaging-guided ability to monitor abnormal mitochondrial morphology during PDT. Importantly, the results of mice experiments also showed that the liposome-based nanophotosensitizer possessed excellent antitumor PDT activity because the released photosensitizer can stay inside mitochondria during the whole process of PDT.

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A Dual‐Nanozyme‐Catalyzed Cascade Reactor for Enhanced Photodynamic Oncotherapy against Tumor Hypoxia

Cited by 54 publications

References 44 publications

Open-Source and Reduced-Expenditure Nanosystem with ROS Self-Amplification and Glutathione Depletion for Simultaneous Augmented Chemodynamic/Photodynamic Therapy

Open-Source and Reduced-Expenditure Nanosystem with ROS Self-Amplification and Glutathione Depletion for Simultaneous Augmented Chemodynamic/Photodynamic Therapy

Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

Liposome-Based Nanoencapsulation of a Mitochondria-Stapling Photosensitizer for Efficient Photodynamic Therapy

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