A dual signal amplification strategy based on scanning electrochemical microscopy for DNA biosensing using a PEDOT-modified ultramicroelectrode and long self-assembled DNA concatemers

In Situ Monitoring of Extracellular K+ Using the Potentiometric Mode of Scanning Electrochemical Microscopy with a Carbon-Based Potassium Ion-Selective Tip

“…However, the half-wave potential and curve shape of the modified tip are almost the same as those of the unmodified one, which indicates that the modified tip still maintains the microelectrode morphology. The K + -ISE SECM tip was further exploited in the feedback mode over an insulating substrate to draw an approach curve, thus calculating the distance between the tip and the substrate Figure C shows the approach curve, showing the relationship between the normalized current and distance (black curve).…”

“…The K + -ISE SECM tip was further exploited in the feedback mode over an insulating substrate to draw an approach curve, thus calculating the distance between the tip and the substrate. 29 Figure 1C shows the approach curve, showing the relationship between the normalized current and distance (black curve). The normalized current is calculated by dividing the generated tip current by the steady-state current in the solution, and the normalized distance is represented by L = d/a, where d is the distance between the tip and cell and a is the radius of the tip.…”