A dynamic Boolean network reveals that the BMI1 and MALAT1 axis is associated with drug resistance by limiting miR-145-5p in non-small cell lung cancer

Gupta, Shantanu; Silveira, Daner A.; Piedade, Gabriel P.S.; Ostrowski, Miguel P.; Mombach, José Carlos M.; Hashimoto, Ronaldo F.

doi:10.1016/j.ncrna.2023.10.008

Cited by 5 publications

(3 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 22 Moreover, a KLF4/p53/miR‐145 regulatory circuit was found in regulating NSCLC drug sensitivity. 23 In this study, we found KLF4 may be associated with LUAD polyamine metabolism and platinum‐based chemotherapy. However, the effects of KLF4 on functions and mechanisms of LUAD still need to be verified by further cellular experiments.…”

Section: Discussionmentioning

confidence: 57%

A risk score based on polyamine metabolism and chemotherapy‐related genes predicts prognosis and immune cells infiltration of lung adenocarcinoma

Du,

Meng,

Zhou

et al. 2024

J Cellular Molecular Medi

View full text Add to dashboard Cite

We aimed to explore whether the genes associated with both platinum‐based therapy and polyamine metabolism could predict the prognosis of LUAD. We searched for the differential expression genes (DEGs) associated with platinum‐based therapy, then we interacted them with polyamine metabolism‐related genes to obtain hub genes. Subsequently, we analysed the main immune cell populations in LUAD using the scRNA‐seq data, and evaluated the activity of polyamine metabolism of different cell subpopulations. The DEGs between high and low activity groups were screened to identify key DEGs to establish prognostic risk score model. We further elucidated the landscape of immune cells, mutation and drug sensitivity analysis in different risk groups. Finally, we got 10 hub genes associated with both platinum‐based chemotherapy and polyamine metabolism, and found that these hub genes mainly affected signalling transduction pathways. B cells and mast cells with highest polyamine metabolism activity, while NK cells were found with lowest polyamine metabolism activity based on scRNA‐seq data. DEGs between high and low polyamine metabolism activity groups were identified, then 6 key genes were screened out to build risk score, which showed a good predictive power. The risk score showed a universal negative correlation with immunotherapy checkpoint genes and the cytotoxic T cells infiltration. The mutation rates of EGFR in low‐risk group was significantly higher than that of high‐risk group. In conclusion, we developed a risk score based on key genes associated with platinum‐based therapy and polyamine metabolism, which provide a new perspective for prognosis prediction of LUAD.

show abstract

Section: Discussionmentioning

confidence: 57%

A risk score based on polyamine metabolism and chemotherapy‐related genes predicts prognosis and immune cells infiltration of lung adenocarcinoma

Du,

Meng,

Zhou

et al. 2024

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Exosome-derived miR-522-3p released by lung cancer cells carrying epidermal growth factor receptor T790M mutation can propagate gefitinib resistance in sensitive cells by activating the PI3K/Akt signaling pathway ( 85 ). Gupta et al ( 86 ) found that activating miR-145 represents a potential strategy to significantly reduce drug resistance in NSCLC through targeting MALAT1 and BMI1.…”

Section: The Role Of Exosome-derived Mirnas In Lung Cancer Drug Resis...mentioning

confidence: 99%

Exosomal microRNAs in lung cancer: a narrative review

Zhang,

Lin,

et al. 2024

Transl Cancer Res

View full text Add to dashboard Cite

Background and Objective Exosomes are nanoscale extracellular vesicles secreted by cells, which can release bioactive macromolecules, such as microRNA (miRNA) to receptor cells. Exosomes can efficiently penetrate various biological barriers which mediate intercellular communication. MiRNA are a class of non-coding RNA that primarily regulate messenger RNA (mRNA) at the post-transcriptional level. MiRNA is abundant in exosomes, which plays an important role by being transported and released through exosomes secreted by lung cancer cells. This review aims to elucidate the roles of exosome-derived miRNAs in lung cancer. Methods We focused on the roles of exosome-derived miRNAs in cancer occurrence and development, including angiogenesis, cell proliferation, invasion, metastasis, immune escape, drug resistance, and their clinical value as new diagnostic and prognostic markers for lung cancer. Key Content and Findings Exosomal miRNA can not only affect angiogenesis of lung cancer, induce epithelial-mesenchymal transformation, and promote reprogramming of tumor microenvironment, but also affect immune regulation and drug resistance transmission and participate in regulating lung cancer cell proliferation. Therefore, understanding the regulatory roles of exosomal miRNAs in tumor invasion and metastasis can provide new ideas for the treatment of lung cancer. Conclusions Exosomal miRNA can provide some unique ideas on how to improve the efficiency of diagnosis and treatment of lung cancer in the future. Targeting tumor-specific exosomal miRNA represents a new strategy for clinical treatment of lung cancer, which can provide potential non-invasive biomarkers in the early diagnosis of lung cancer. Investigation of the involvement of exosomal miRNAs in the occurrence and progression of tumors can yield new opportunities for the clinical diagnosis and treatment of lung cancer.

show abstract

“…In particular, the dysregulation of lncRNAs are critically involved in the pathogenesis of cancer [ 18 – 20 ]. LncRNAs frequently function to establish intermolecular interactions with other biomolecules, including proteins, DNAs, and other RNAs [ 18 , 21 – 24 ]. This enables lncRNAs to act as tethers, guides, decoys or scaffolds to undertake various biological functions, including cancer development, progression, and treatment resistance [ 25 – 28 ].…”

Section: Introductionmentioning

confidence: 99%

LINC01559 promotes lung adenocarcinoma metastasis by disrupting the ubiquitination of vimentin

Feng,

Xu,

Jiang

et al. 2024

Biomark Res

View full text Add to dashboard Cite

Background Distant metastasis is the major cause of lung adenocarcinoma (LUAD)-associated mortality. However, molecular mechanisms involved in LUAD metastasis remain to be fully understood. While the role of long non-coding RNAs (lncRNAs) in cancer development, progression, and treatment resistance is being increasingly appreciated, the list of dysregulated lncRNAs that contribute to LUAD pathogenesis is also rapidly expanding. Methods Bioinformatics analysis was conducted to interrogate publicly available LUAD datasets. In situ hybridization and qRT-PCR assays were used to test lncRNA expression in human LUAD tissues and cell lines, respectively. Wound healing as well as transwell migration and invasion assays were employed to examine LUAD cell migration and invasion in vitro. LUAD metastasis was examined using mouse models in vivo. RNA pulldown and RNA immunoprecipitation were carried out to test RNA–protein associations. Cycloheximide-chase assays were performed to monitor protein turnover rates and Western blotting was employed to test protein expression. Results The expression of the lncRNA LINC01559 was commonly upregulated in LUADs, in particular, in those with distant metastasis. High LINC01559 expression was associated with poor outcome of LUAD patients and was potentially an independent prognostic factor. Knockdown of LINC01559 diminished the potential of LUAD cell migration and invasion in vitro and reduced the formation of LUAD metastatic lesions in vivo. Mechanistically, LINC01559 binds to vimentin and prevents its ubiquitination and proteasomal degradation, leading to promotion of LUAD cell migration, invasion, and metastasis. Conclusion LINC01559 plays an important role in LUAD metastasis through stabilizing vimentin. The expression of LINC01559 is potentially an independent prognostic factor of LUAD patients, and LINC01559 targeting may represent a novel avenue for the treatment of late-stage LUAD.

show abstract

A dynamic Boolean network reveals that the BMI1 and MALAT1 axis is associated with drug resistance by limiting miR-145-5p in non-small cell lung cancer

Cited by 5 publications

References 56 publications

A risk score based on polyamine metabolism and chemotherapy‐related genes predicts prognosis and immune cells infiltration of lung adenocarcinoma

A risk score based on polyamine metabolism and chemotherapy‐related genes predicts prognosis and immune cells infiltration of lung adenocarcinoma

Exosomal microRNAs in lung cancer: a narrative review

LINC01559 promotes lung adenocarcinoma metastasis by disrupting the ubiquitination of vimentin

Contact Info

Product

Resources

About