A dynamic computational network model for the role of nitric oxide and the myogenic response in microvascular flow regulation

Liu, Yien; Buerk, Donald G.; Barbee, Kenneth A.; Jaron, Dov

doi:10.1111/micc.12465

“…Refs. [ [42] , [43] , [44] , [45] , [46] , [47] , [48] ]). Therefore, here we used reaction-diffusion-advection models to estimate how far O 2 •− and H 2 O 2 can travel through capillaries, arterioles and arteries, and what concentrations are attainable under conditions where ECs release O 2 •− in excess of • NO or release H 2 O 2 .…”

Section: Introductionmentioning

confidence: 99%

How abundant are superoxide and hydrogen peroxide in the vasculature lumen, how far can they reach?

Sousa

¹

,

Gouveia

²

,

Travasso

³

et al. 2022

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“…An important determinant of arterial pressure is peripheral vascular resistance, which in turn is primarily determined by the diameter of small arteries and arterioles which are referred to as resistance vessels [1]. The walls of the resistance vessels have smooth muscle cells arranged in a concentric fashion in the tunica media which is referred to as circular smooth muscle [2]. Contraction of circular smooth muscle reduces lumen diameter and therefore increases vascular resistance [1,3].…”

Section: Introductionmentioning

confidence: 99%

Phenylephrine induces relaxation of longitudinal strips from small arteries of goat legs

Marconi

¹

,

Bharathi

²

,

Venis

³

et al. 2020

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Alpha adrenergic stimulation is known to produce vasoconstriction. We have earlier shown that, in spiral strips of small arteries Phenylephrine (PE) caused vasorelaxation under high nitric oxide (NO) environment. However, on further experimentation it was realized that the PE-induced vasorelaxant response occurred only with longitudinal strips of small arteries even under normal NO environment while circular strips showed contraction with PE even under high NO environment. Such PE-induced vasorelaxation of longitudinal strips was blocked by Phentolamine, an alpha-adrenergic receptor blocker. On delineation of specific receptor subtype, PE-induced relaxation was found to be mediated through alpha 1D receptor. However, this phenomenon is specific to small artery, as longitudinal smooth muscle of aorta showed only contractile response to adrenergic stimulation. There is no prior report of longitudinal smooth muscle in small artery up to our knowledge. The results of this study and histological examination of vessel sections suggest the presence of longitudinal smooth muscle in small artery and their relaxant response to alpha adrenergic stimulation is a novel phenomenon. Phenyl ephrine relaxes longitudinal strips of small arteries PLOS ONE | https://doi.org/10.1371/journal.pone.0227316 March 3, 2020 2 / 17 PE induces relaxation of longitudinal smooth muscle of small artery both under normal and high NO environmentsPE 100μmol/L reduced the tension of longitudinal smooth muscle from 0.25g to 0.09g in small arteries. (Median, n = 5, P value = 0.043, WSR), Fig 5, (i)). While L-Arginine 100μmol/L did not reduce the basal tension by itself, subsequent addition of PE 100μmol/L reduced the tension from 0.28 to 0.07g (Median, n = 5, P value = 0.043, WSR), Fig 5, (ii). Fig 4. (A) Raw tracing showing changes in vascular tension with PE 100μmol/L in transverse cylinder preparation of small artery. (B) Scatter plots of results from all five experiments demonstrating change in vascular tension with PE from baseline. ( � p = 0.043, WSR), (i) PE 100μmol/L (ii) PE in the presence of L-Arginine (iii) PE in the presence of NO synthase blocker L-NNA.

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“…An important determinant of arterial pressure is peripheral vascular resistance, which in turn is primarily determined by the diameter of small arteries and arterioles which are referred to as resistance vessels (1). The walls of the resistance vessels have smooth muscle cells arranged in a concentric fashion in the tunica media which is referred to as circular smooth muscle (2). Contraction of circular smooth muscle reduces lumen diameter and therefore increases vascular resistance (1) (3).…”

Section: Introductionmentioning

confidence: 99%

Phenylephrine induces relaxation of longitudinal strips from small arteries of goat legs

Marconi

¹

,

Bharathi

²

,

Venis

³

et al. 2019

Preprint

View full text Add to dashboard Cite

Alpha adrenergic stimulation is known to produce vasoconstriction. We have earlier shown that, in spiral strips of small arteries Phenylephrine (PE) caused vasorelaxation under high nitric oxide (NO) environment. However on further experimentation it was realized that the PE-induced vasorelaxant response occurred only with longitudinal strips of small arteries even under normal NO environment while circular strips showed contraction with PE even under high NO environment. Such PE-induced vasorelaxation of longitudinal strips was blocked by Phentolamine, an alpha-adrenergic receptor blocker. On delineation of specific receptor subtype, PE-induced relaxation was found to be mediated through alpha 1D receptor. However, this phenomenon is specific to small artery, as longitudinal smooth muscle of aorta showed only contractile response to adrenergic stimulation. There is no prior report of longitudinal smooth muscle in small artery up to our knowledge. The results of this study and histological examination of vessel sections suggest the presence of longitudinal smooth muscle in small artery and their relaxant response to alpha adrenergic stimulation is a novel phenomenon.

show abstract

A dynamic computational network model for the role of nitric oxide and the myogenic response in microvascular flow regulation

Abstract: Our model predicts the steady state and transient behavior of resistance vessels to perturbations in blood pressure, including effects of NO bioavailability on vascular regulation.

Cited by 7 publications

References 43 publications

How abundant are superoxide and hydrogen peroxide in the vasculature lumen, how far can they reach?

How abundant are superoxide and hydrogen peroxide in the vasculature lumen, how far can they reach?

Phenylephrine induces relaxation of longitudinal strips from small arteries of goat legs

Phenylephrine induces relaxation of longitudinal strips from small arteries of goat legs

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