A dynamic mechanical method to assess bulk viscoelastic behavior of the dentin extracellular matrix

Alania, Yvette; Reis, Mariana; Nam, Joo‐Won; Phansalkar, Rasika S.; McAlpine, James B.; Chen, Shao-Nong; Pauli, Guido F.; Bedran-Russo, Ana K.

doi:10.1016/j.dental.2020.09.014

Cited by 14 publications

(23 citation statements)

References 35 publications

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“…Further, all groups except HV GAKO and control followed the trend characterized by a drop after 1 month, before reaching a plateau. Lower tan δ has been associated with collagen crosslinking predominantly via covalent intermolecular linkages, 27,33 due to their strong and highly stable nature. 33 After 6 months, the damping capacity of control group showed a clear trend leading to an increased tan δ, revealing a more viscous-like behavior.…”

Section: Discussionmentioning

confidence: 99%

“…Variations in viscoelastic response, observed in control group are likely due to initial signs of degradation, as a result of the inherent endogenous activity of metalloproteinases. 27,34 F I G U R E 4 Biodegradation rates (%) of dentin matrices upon PACs-mediated biomodification. Symbol (*) depicts statistical differences between groups (p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…The response of a viscoelastic material such as the dentin ECM, is measured as it is deformed over a range of strain. Here, we used a micro‐DMA method, to determine the viscoelastic properties of bulk dentin matrix 27 . After treatment, specimens were placed in a three‐point bending submersion clamp (Q800 DMA, TA Instruments, New Castle, DE) and a strain sweep was conducted with predefined parameters (frequency: 1 Hz, amplitude: 1 to 100 μm and preload force: 0.01 N) 27 .…”

Section: Methodsmentioning

confidence: 99%

“…27 After treatment, specimens were placed in a threepoint bending submersion clamp (Q800 DMA, TA Instruments, New Castle, DE) and a strain sweep was conducted with predefined parameters (frequency: 1 Hz, amplitude: 1 to 100 μm and preload force: 0.01 N). 27 Specimens were tested in distilled water immersion at room temperature. The storage modulus (E 0 ), representing the elastic properties of a material and the damping capacity, describing the ability of the material to dissipate energy (tan δ = loss modulus [E 00 ]/E 0 ), were both calculated within the linear region of viscoelasticity.…”

Section: Dynamic Mechanical Analysis (Dma) Of Dentin Matrixmentioning

confidence: 99%

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Paradoxical effects of galloyl motifs in the interactions of proanthocyanidins with collagen‐rich dentin

Alania

Zhou

Reis

et al. 2021

J Biomedical Materials Res

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Dynamic Mechanical Analysis (Dma) Of Dentin Matrixmentioning

confidence: 99%

See 2 more Smart Citations

Paradoxical effects of galloyl motifs in the interactions of proanthocyanidins with collagen‐rich dentin

Alania

Zhou

Reis

et al. 2021

J Biomedical Materials Res

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“…IR spectroscopy was used to track the polymerization kinetics of dental resins [ 73 , 74 ] and adhesives [ 75 , 76 , 77 , 78 ] to improve the mechanical features of the dental material. The IR technique was also used to determine the role of intermolecular collagen cross-linking in the mechanical behaviour of dentin [ 79 ], to evaluate the structure of heterocyclic compounds as candidates for pulp regeneration [ 80 ] and to analyse new generation biomimetic materials replicating the mineral organic dentin and enamel complex [ 81 ].…”

Section: Infrared Spectroscopy (Ir) and Fourier Transform Infrared Spectroscopy (Ft-ir)mentioning

confidence: 99%

Selected Spectroscopic Techniques for Surface Analysis of Dental Materials: A Narrative Review

et al. 2021

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The presented work focuses on the application of spectroscopic methods, such as Infrared Spectroscopy (IR), Fourier Transform Infrared Spectroscopy (FT-IR), Raman spectroscopy, Ultraviolet and Visible Spectroscopy (UV-Vis), X-ray spectroscopy, and Mass Spectrometry (MS), which are widely employed in the investigation of the surface properties of dental materials. Examples of the research of materials used as tooth fillings, surface preparation in dental prosthetics, cavity preparation methods and fractographic studies of dental implants are also presented. The cited studies show that the above techniques can be valuable tools as they are expanding the research capabilities of materials used in dentistry.

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Modulatory role of terminal monomeric flavan‐3‐ol units in the viscoelasticity of dentin

Reis‐Havlat,

Alania,

Zhou

et al. 2023

J Biomed Mater Res

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Flavan‐3‐ol monomers are the building blocks of proanthocyanidins (PACs), natural compounds from plants shown to mediate specific biologic activities on dentin. While the stereochemistry of the terminal flavan‐3‐ols, catechin (C) versus epicatechin (EC), impacts the biomechanical properties of the dentin matrix treated with oligomeric PACs, structure–activity relationships driving this bioactivity remain elusive. To gain insights into the modulatory role of the terminal monomers, two highly congruent trimeric PACs from Pinus massoniana only differing in the stereochemistry of the terminal unit (Trimer‐C vs. Trimer‐EC) were prepared to evaluate their chemical characteristics as well as their effects on the viscoelasticity and biostability of biomodified dentin matrices via infrared spectroscopy and multi‐scale dynamic mechanical analyses. The subtle alteration of C versus EC as terminal monomers lead to distinct immediate PAC‐trimer biomodulation of the dentin matrix. Nano‐ and micro‐dynamic mechanical analyses revealed that Trimer‐EC increased the complex moduli (0.51 GPa) of dentin matrix more strongly than Trimer‐C (0.26 GPa) at the nanoscale length (p < 0.001), whereas the reverse was found at the microscale length (p < .001). The damping capacity (tan δ) of dentin matrix decreased by 70% after PAC treatment at the nano‐length scale, while increased values were found at the micro‐length scale (~0.24) compared to the control (0.18 ; p < .001). An increase in amide band intensities and a decrease of complex moduli was observed after storage in simulated body fluid for both Trimer‐C and Trimer‐EC modified dentin. The stereochemical configuration of the terminal monomeric units, C and EC, did not impact the chemo‐mechanical stability of dentin matrix.

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A dynamic mechanical method to assess bulk viscoelastic behavior of the dentin extracellular matrix

Cited by 14 publications

References 35 publications

Paradoxical effects of galloyl motifs in the interactions of proanthocyanidins with collagen‐rich dentin

Paradoxical effects of galloyl motifs in the interactions of proanthocyanidins with collagen‐rich dentin

Selected Spectroscopic Techniques for Surface Analysis of Dental Materials: A Narrative Review

Modulatory role of terminal monomeric flavan‐3‐ol units in the viscoelasticity of dentin

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